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Ketosis Prevents Abdominal Aortic Aneurysm Progression and Rupture in Male Rats

Open AccessPublished:June 10, 2022DOI:https://doi.org/10.1016/j.jvssci.2022.05.027

      Background

      Abdominal aortic aneurysms (AAA) are common in aging populations, and its rupture is associated with high mortality. There is no effective medical therapy for the prevention of AAA expansion and rupture. Ketone bodies (KB) are argued to produce novel responses against injury. Serum KB are elevated through a ketogenic diet (KD) or the intake of exogenous KB (EKB). We hypothesize that ketosis can reduce AAA expansion and risk of rupture.

      Methods

      Male Sprague-Dawley rats underwent intraluminal exposure to porcine pancreatic elastase to induce AAA formation. Rats were also administered daily β-aminopropionitrile to promote AAA rupture. Control rats (n = 12) were fed a standard diet (SD). Treated rats were given either a KD (n = 9) or EKB (n = 10) starting 3 days after AAA induction. Ketosis was verified by blood beta-hydroxybutyrate level of greater than 0.5 mmol/L. The in vivo aortic diameter was evaluated by ultrasound examination.