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Proteomic analysis of descending thoracic aorta identifies unique and universal signatures of aneurysm and dissection

Open AccessPublished:January 21, 2022DOI:https://doi.org/10.1016/j.jvssci.2022.01.001

      Abstract

      Objective

      Very few clinical predictors of descending thoracic aorta dissection have been determined. Although aneurysms can dissect in a size-dependent process, most descending dissections will occur without prior enlargement. We compared the proteomic profiles of normal, dissected, aneurysm, and both aneurysm and dissected descending thoracic aortas to identify novel biomarkers and further understand the molecular pathways that lead to tissue at risk of dissection.

      Methods

      We performed proteomic profiling of descending thoracic aortas with four phenotypes: normal (n = 46), aneurysm (n = 22), dissected (n = 12), and combined aneurysm and dissection (n = 8). Pairwise differential protein expression analyses using a Bayesian approach were then performed to identify common proteins that were dysregulated between each diseased tissue type and control aorta and to uncover unique proteins between aneurysmal and dissected aortas. Network and Markov cluster algorithms of differentially expressed proteins were used to find enriched ontology processes. A convex analysis of mixtures was also performed to identify the molecular subtypes within the different tissue types.

      Results

      The diseased aortas had 71 common differentially expressed proteins compared with the control, including higher amounts of the protein thrombospondin 1. We found 42 differentially expressed proteins between the aneurysm and dissected tissue, with an abundance of apolipoproteins in the former and higher quantities of extracellular matrix proteins in the latter. The convex analysis of mixtures showed enhancement of a molecular subtype enriched in contractile proteins within the control tissue compared with the diseased tissue, in addition to increased proportions of molecular subtypes enriched in inflammation and red blood cell expression in the aneurysmal compared with the dissected tissue.

      Conclusions

      We found some overlapping differentially expressed proteins in aneurysmal and nonaneurysmal descending thoracic aortas at risk of dissection compared with normal aortas. However, we also found uniquely altered molecular pathways that might uncover mechanisms for dissection.

      Clinical Relevance

      Diseases of the descending thoracic aorta such as aneurysms and dissections carry a high degree of morbidity and mortality. At present, a complete understanding is still lacking of the genetics that drive these diseases and why some aortic segments dissect in the presence or absence of an aneurysm. We compared and contrasted the whole proteome expression of descending aortas from patients with normal, dissected, aneurysmal, and aneurysmal with dissected pathology aortic tissue. We uncovered potential tissue markers that might serve as future targets for therapy or predictors of disease progression.

      Keywords

      Article Highlights
      • Type of Research: A single-center, prospective case-control study
      • Key Findings: Proteomic profiling of 88 descending thoracic aortas uncovered increased levels of thrombospondin 1 as a universal marker of aneurysms and dissection. In contrast, the levels of key extracellular matrix proteins were greater in dissected tissue and the apolipoprotein levels were higher in aneurysms.
      • Take Home Message: Descending thoracic aortas at risk of dissection from aneurysmal or nonaneurysmal precursors have common proteomic signatures, with the exception of certain key pathways.
      Acute aortic syndromes are among the deadliest forms of cardiovascular disease. In particular, type A aortic dissections carry a high risk of mortality. In contrast, most patients with type B dissections will survive hospitalization, although the rates of morbidity and mortality have continued to be high.
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      Acute aortic dissection: perspectives from the International Registry of Acute Aortic Dissection (IRAD).
      Predicting which patients will be at risk of acute dissection is extremely difficult. The aortic size has continued to be one of the few risk factors routinely used in clinical practice. Pathologically, aneurysms of the thoracic aorta result from medial degeneration. This destruction causes the wall to thin, grow, and weaken, which is thought to increase the likelihood of dissection under pressure.
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      However, many recent studies have shown that a significant number of both type A and B dissections will occur at sizes well below the current guidelines for surgical management. More than 80% of type B dissections can occur at diameters <5.5 cm, with little to no enlargement at all.
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      Aortic diameter > or = 5.5 cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aortic Dissection (IRAD).
      The pathology underlying these nonaneurysmal dissections is much less understood. In addition, aneurysms will often be mostly silent, resulting in few clinical symptoms. At times, they will be identified incidentally on diagnostic imaging or through a family history. Nonaneurysmal aortas at risk of dissection go almost completely undetected.
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      Familial thoracic aortic aneurysms and dissections—incidence, modes of inheritance, and phenotypic patterns.
      As such, novel screening methods are desperately needed to help predict which patients are at risk of acute dissection.
      In the present study, we surveyed the proteome of descending thoracic aortas from four different populations: normal descending thoracic aorta, type B aortic dissection (TBAD), descending thoracic aortic aneurysm (TAA), and combined type B dissection with aneurysm (TADA). Our goal was to identify a molecular signature that could be used to better understand the underlying pathology and, ultimately, predict the patients at risk of dissection, regardless of the presence of an aneurysm. The proteins unique to each pathology compared with the control tissue and the overlapping differentially expressed proteins from all disease states were identified using a pairwise Bayesian approach. We also identified a unique set of proteins and molecular subtypes that distinguished TBAD from TAA, which might provide insight into the mechanism of how aortic tissue dissects in the presence or absence of an aneurysm.

      Methods

      Patients and tissue samples

      We prospectively enrolled 42 patients undergoing aortic surgery for aneurysm repair or chronic aortic dissection. Normally discarded descending thoracic aortic tissue was extracted from the operating room and flash frozen for later use. An additional 46 normal descending thoracic aortas were taken at autopsy <24 hours after death from individuals in accordance with approved procedures and institutional review board approval described in detail previously.
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      Proteomic architecture of human coronary and aortic atherosclerosis.
      The University of Texas Medical Center review board approved the procedures for aneurysm and dissection sample acquisition (principal investigators, D.M.M. and A.A.). The patient demographics, including sex, were obtained from the electronic medical records (Table I). The cause of death for the control patients is listed in Supplementary Table I.
      Table IPatient demographics
      Aortic pathologyAge, yearsMale sexWhite raceCADCOPDHTNPVDCVAFamily history
      Family history of aortic dissection or aneurysm.
      Control (n = 46)41.93 ± 8.087672NANANANANANA
      TAA (n = 22)45.45 ± 7.9686452010100000
      TBAD (n = 12)43.5 ± 11.49753300500025
      TADA (n = 8)48.13 ± 8.0875380010016.7016.7
      CAD, Coronary artery disease; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular accident; HTN, hypertension; NA, not available; PVD, peripheral vascular disease; TAA, thoracic aorta aneurysm; TADA, thoracic aorta dissection and aneurysm; TBAD, type B dissecting aorta.
      Data presented as mean ± standard deviation or %.
      a Family history of aortic dissection or aneurysm.

      Sample preparation and mass spectrometry

      The flash frozen tissue samples were pulverized over a bath of liquid nitrogen into a fine powder. The tissue powder was solubilized in a 6 M urea 0.1% RapiGest (Waters, Milford, Mass) lysis buffer, and the proteins were extracted using high pressure cycling on a barocyler instrument (Pressure Biosciences, Easton, Mass) with 45 × 60-second cycles consisting of 50 seconds at high pressure (40 PSI) followed by 10 seconds at normal atmospheric pressure. The protein concentration of the lysates was determined, and 50 μg of protein was allocated, reduced with 10 mM dithiothreitol, alkylated with 100 mM iodoacetamide, and digested with 1:20 trypsin/protein ratio using sequencing grade trypsin/LysC mix (Promega, Madison, Wis) in the presence of 10% acetonitrile. The digested peptides were partially dried, and the pH of the residual solution was adjusted to <2 with the addition of 10% formic acid (FA). Digested peptides were partially dried, and pH was lowered to <2 with the addition of 10% FA. The acidified samples were desalted on Waters C18 desalting plates (Waters) according to the manufacturer’s protocol. Desalted peptides were dried and resuspended at 1 μg/μL in 0.1% FA in high-performance liquid chromatography–grade water and mixed 1:1 with a 1:20 dilution of indexed retention time standard peptides (Biogynosys, Schlieren, Switzerland) for a final loading concentration of 0.5 μg/μL.
      A total of 4 μg of peptide was loaded onto a 15-cm C18 reverse-phase column attached to an Eksigent 415 HPLC system operating in microflow mode equipped with an Ekspert nanoLC 400 autosampler. The peptides were first loaded onto a trap column (10 × 0.3 mm, C18CL, 5 μm, 120Å; Sciex, Framingham, Mass) for 3 minutes at 10 μL/min of solvent A (0.1% FA in water) followed by separation on an analytical column (ChromXP C18CL, 150 × 0.3 mm, 3 μm, 120Å; Sciex) at a flow rate of 5 μL/min using a linear AB gradient of 3% to 35% solvent B (0.1% FA in acetonitrile) for 60 minutes, 35% to 85% solvent B for 2 minutes, holding at 85% solvent B for 5 minutes, followed by reequilibration at 3% solvent B for 7 minutes. Mass spectra were collected in data independent acquisition mode, with the instrument looping through an initial MS1 scan of 250 ms (range, 400-1250 m/z), followed by acquisition of 100 MS2 scans of 30 ms (range, 100-1800 m/z) from peptide ions filtered through mass windows of variable width. The total cycle time was 3.3 seconds, allowing for a minimum of 10 sampled points across a given chromatographic peak for subsequent quantification of peptide MS2 fragments. Source gas 1 was set to 15 PSI, gas 2 was set to 20 PSI, and curtain gas was set to 25 PSI. The source temperature was set to 100°C, and source voltage was set to 5500 V.

      Peptide library, normalization, and imputation

      The peptide peak groups were extracted from a customized library consisting of an existing library of pooled human vascular lysates described previously
      • Herrington D.M.
      • Mao C.
      • Parker S.J.
      • Fu Z.
      • Yu G.
      • Chen L.
      • et al.
      Proteomic architecture of human coronary and aortic atherosclerosis.
      (available at: http://www.peptideatlas.org/PASS/PASS01066) merged with the Q1 pseudospectra files extracted from the sample-specific DIA files (generated as described) using the DIA-Umpire signal extraction module.
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      • Choi H.
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      DIA-Umpire: comprehensive computational framework for data-independent acquisition proteomics.
      The groups were searched and formatted as a peptide library as described in detail previously.
      • Parker S.J.
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      • Van Eyk J.E.
      Effect of peptide assay library size and composition in targeted data-independent acquisition-MS analyses.
      Peptide groups containing up to six fragment ions were extracted from the library using the openSWATH workflow
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      OpenSWATH enables automated, targeted analysis of data-independent acquisition MS data.
      and implemented in-house, as described previously.
      • Herrington D.M.
      • Mao C.
      • Parker S.J.
      • Fu Z.
      • Yu G.
      • Chen L.
      • et al.
      Proteomic architecture of human coronary and aortic atherosclerosis.
      ,
      • Parker S.J.
      • Chen L.
      • Spivia W.
      • Saylor G.
      • Mao C.
      • Venkatraman V.
      • et al.
      Identification of putative early atherosclerosis biomarkers by unsupervised deconvolution of heterogeneous vascular proteomes.
      In brief, the peptide peak groups were extracted from the raw data and the identifications scored according to multiple metrics. Decoy peak groups in the peptide assay facilitate modeling of the peptide score distributions and assignment of false discovery. The TRIC algorithm then aligns the peptide identifications across the experiment.
      • Röst H.L.
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      • D'Agostino G.
      • Zanella M.
      • Navarro P.
      • Rosenberger G.
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      TRIC: an automated alignment strategy for reproducible protein quantification in targeted proteomics.
      The fragment level intensities from each file were normalized to the total extracted MS2 signal intensity of that file (eg, akin to normalization to total protein in a Western blot), and normalized MSSTATS software was used to aggregate the fragment level data into protein intensities.
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      • et al.
      MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments.

      Differential protein expression

      Differential protein analysis was performed on log-transformed abundances using the LIMMA package in R studio.
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      • Phipson B.
      • Wu D.
      • Hu Y.
      • Law C.W.
      • Shi W.
      • et al.
      LIMMA powers differential expression analyses for {RNA}-sequencing and microarray studies.
      A log2 fold change of 1.0 and an adjusted P value of < .05 (false discovery rate) was used for the cutoff parameters. A complete list of all pairwise analyses is presented in Supplementary Tables II and III.

      Protein networks, heatmaps, and principal component analysis

      Protein networks were constructed using the STRING interaction network, and their visualization was customized in cytoscape.
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      • Franceschini A.
      • Wyder S.
      • Forslund K.
      • Heller D.
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      • et al.
      STRING v10: protein-protein interaction networks, integrated over the tree of life.
      ,
      • Shannon P.
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      • et al.
      Cytoscape: a software environment for integrated models of biomolecular interaction networks.
      Clustering was performed using the MCL method with an inflation parameter set to 3. Gene ontology was conducted on clusters, and enrichments were considered significant at P < .05 (false discovery rate). Heatmaps and principal component analysis were conducted in R studio using the package ggplots2.
      RStudio Team
      RStudio: Integrated Development for R. RStudio, PBC.

      Application of convex analysis of mixtures across the DIA-MS protein data from unselected specimens

      To explore the underlying heterogeneity in molecular subtypes present within the tissue homogenates (eg, lysates reflecting multiple contributing cell types), we implemented the convex analysis of mixtures (CAM) pipeline,
      • Wang N.
      • Gong T.
      • Clarke R.
      • Chen L.
      • Shih Ie M.
      • Zhang Z.
      • et al.
      UNDO: a bioconductor R package for unsupervised deconvolution of mixed gene expressions in tumor samples.
      ,
      • Wang N.
      • Hoffman E.P.
      • Chen L.
      • Chen L.
      • Zhang Z.
      • Liu C.
      • et al.
      Mathematical modelling of transcriptional heterogeneity identifies novel markers and subpopulations in complex tissues.
      the methods and function of which have been described in detail previously.
      • Parker S.J.
      • Chen L.
      • Spivia W.
      • Saylor G.
      • Mao C.
      • Venkatraman V.
      • et al.
      Identification of putative early atherosclerosis biomarkers by unsupervised deconvolution of heterogeneous vascular proteomes.
      Pertinent modifiable settings were the elimination of signals outside of a 5%- to 95%-interval of total intensity and k for the minimum descriptive length parameterization set to test 2 to 10 putative subtypes. The most likely subtype number was determined from the minima of the minimum descriptive length plot, and the CAM workflow was then used to determine the protein markers of each subtype by first predicting the expression proportions for each protein across the six subtypes and identifying the proteins with dominant or exclusive predicted expression in one subtype relative to the others. Finally, the algorithm was used to estimate the relative proportions of each subtype present in each sample from the dataset. Marker protein gene ontology analysis was performed using the ShinyGO online portal.
      • Ge S.X.
      • Jung D.
      • Yao R.
      ShinyGO: a graphical gene-set enrichment tool for animals and plants.
      The top five nonredundant gene otology biological process enrichments for each subtype were used to summarize the overall functional enrichment profile and infer the hypothesized subtype identity.

      Histologic findings

      Representative tissue samples from the diseased groups were fixed in formaldehyde and embedded in paraffin for sectioning. The samples were sliced in 5-μm sections and stained with hematoxylin and eosin, trichrome, and elastin (ELN)-Van Giessen. The images were captured using the ECHO Revolve microscope (ECHO, San Diego, Calif).

      Western blot

      Protein lysates were reduced in loading buffer, run on acrylamide gels, and transferred to polyvinylidene fluoride membrane. The membranes were subsequently probed with antibodies against thrombospondin 1 (THBS1; 1:500; sc-59887; Santa Cruz Biotechnology, Dallas, Tex), beta-tubulin (1:1000; Thermo Fisher, Waltham, Mass), and ELN (1:500; sc-166543; Santa Cruz Biotechnology).

      Results

      Aneurysms and dissections share differentially expressed proteins

      After quality measure and removing peptides not present in ≥50% of the samples, 1872 peptides were left. We performed differential protein analysis between the normal descending aorta tissue and each aortic pathology. At a log2 fold change cutoff of 1.0 and an adjusted P value of < .05, the number of differentially expressed proteins was 107 for TADA, 416 for TAA, and 272 for TBAD. A total of 71 proteins were shared among the three comparisons: 12 upregulated and 59 downregulated (Table II and Fig 1). Network analysis with MCL clustering generated 14 clusters of at least two proteins (Fig 2, A). One main cluster consisted of nine proteins. The top five biological process gene ontology enrichments for proteins in this cluster were positive regulation of endothelial cell apoptotic process, negative regulation of chemotaxis, regulation of mononuclear cell migration, peptide cross-linking, and integrin-mediated signaling pathway. The top molecular function enrichments included integrin binding, growth factor binding, and heparin binding. Finally, the top five cellular component enrichments included platelet alpha granule lumen, collagen trimer, endoplasmic reticulum lumen, extracellular matrix, and collagen-containing extracellular matrix (Fig 2, B). With 15 edges, THBS1 had the highest degree within this cluster and within the network. THBS1 was significantly upregulated in each disease group compared with the control. We validated this finding with Western blotting on representative samples from each pathology (Fig 2, C).
      Table IICommon differentially expressed proteins between thoracic aneurysms, dissections, and aneurysms with dissection compared with control
      Protein symbolProtein nameDirection of expressionCAM subtype marker
      IGDCC3Immunoglobulin superfamily DCC subclass member 3Down
      GLD2Poly(A) RNA polymerase GLD2Down
      FABP1Fatty acid-binding protein 1DownS4
      CELSR3Cadherin EGF seven-pass G-type receptor 3DownS4
      FURINFurinDown
      MBMyoglobinDown
      XDHXanthine dehydrogenaseDownS4
      DCNDecorinDown
      GSSGlutathion synthetaseDown
      MYO18AUnconventional myosin-XVIIIaDownS4
      ACANAggrecan core proteinDownS4
      OR4C3Olfactory receptor family 4 subfamily C member 3Down
      PPM1FProtein phosphatase Mg2+/Mn2+ dependent 1FDown
      CA3Carbonic anhydrase 3Down
      DESDesminDown
      CKMCreatine kinase M-typeDown
      KRT73Keratin 73DownS4
      LSM7U6 SnRNA-associated Sm-like protein LSm7Down
      TPM2Tropomyosin beta chainDownS4
      APPAmyloid-beta A4 proteinDownS4
      ERC2ERC protein 2Down
      RNASE1Ribonuclease pancreaticDown
      MFGE8LactadherinDownS4
      CATSPERGCation channel sperm associated auxiliary subunit gammaDownS4
      SBSPONSomatomedin-B and thrombospondin type-1 domain-containing protein;Down
      FAM198BGolgi associated kinase 1BDownS4
      SPON1Spondin-1Down
      SONProtein SONDownS4
      FILIP1LFilamin A interacting protein 1 likeDownS4
      LGALS3BPGalectin 3 binding proteinDown
      ADGRE5Adhesion G protein-coupled receptor E5Down
      DKK3Dickkopf-related protein 3Down
      TPM1Tropomyosin alpha-1 chainDownS4
      CFPProperdinDownS4
      SPARCL1SPARC-like protein 1DownS4
      CCN3Cellular communication network factor 3Down
      CKBCreatine kinase B-typeDownS4
      SOD3Extracellular superoxide dismutase Cu-ZnDownS4
      FABP4Fatty acid-binding protein 4Down
      COL18A1Collagen type 18 alpha 1 chainDownS4
      THSD1Thrombospondin type 1 domain-containing protein 1DownS4
      VWA1Von Willebrand factor A domain-containing protein 1Down
      TINAGL1Tubulointerstitial nephritis antigen-like precursorDownS4
      ACAT1Acetyl-coenzyme A acetyltransferase 1Down
      RHOBRas homolog family member BDown
      ITGA7Integrin alpha-7DownS4
      SYNMSyneminDown
      GALMGalactose mutarotaseDown
      CRYABAlpha-crystallin B chainDown
      FLNCFilamin-CDown
      RILPL1Rab interacting lysosomal protein like 1Down
      ANXA5Annexin A5Down
      C11orf54Chromosome 11 open reading frame 54Down
      LHPPPhospholysine phosphohistidine inorganic pyrophosphate phosphataseDownS4
      VIMVimentinDownS4
      ALDH1B1Aldehyde dehydrogenase 1 family member B1DownS4
      PSIP1PC4 and SFRS1-interacting proteinDown
      ANXA4Annexin A4Down
      ACTN2Alpha-actinin-2DownS4
      PFKLATP-dependent 6-phosphofructokinaseUpS2
      SLC2A1Solute carrier family 2Up
      FERMT3Fermitin family homolog 3Up
      LMAN2Lectin mannose binding 2Up
      THBS1Thrombospondin 1Up
      PRTN3MyeloblastinUpS6
      ELANENeutrophil elastaseUp
      S100A8S100 calcium binding protein A8UpS6
      SH3RF2SH3 domain containing ring finger 2Up
      FANCAFA complementation group AUpS6
      c8orf74Chromosome 8 open reading frame 74UpS6
      COL3A1Collagen type 3 alpha 1 chainUpS2
      CAM, Convex analysis of mixtures.
      Figure thumbnail gr1
      Fig 1Degenerative aortic syndromes share dysregulated proteins. Venn diagram of overlapping differentially expressed proteins from comparisons between normal aorta and each aortic pathology.
      Figure thumbnail gr2
      Fig 2Degenerative aortic syndromes are enriched in extracellular matrix proteins. A, String network of overlapping proteins from . Relative expression (average Z-scores for a given protein within each experimental group) of each protein in control (C), aneurysm (A), aneurysm with dissection (AD), and dissection (D) is displayed in that order as node bar charts, where orange indicates a relative increased expression and blue, a relative decreased expression. The largest cluster is highlighted in red. B, Biological process (Top), molecular function (Middle), and cellular component (Bottom) ontology analysis for the largest cluster in the network highlighted in red. C, Biomarker protein expression levels by Western blotting for representative samples from control and diseased tissue samples.

      Unique proteins for aneurysms and dissections uncover classic genes associated with degenerative aortas

      We next examined the differentially expressed proteins between the aortic pathologies. No proteins had met our predetermined cutoffs when comparing TADA to either TAA or TBAD. There were, however, 42 differentially expressed proteins between TAA and TBAD (Table III and Fig 3, A and B). Of these 42 proteins, 8 had higher expression in TBAD and 36 in TAA. Network analysis with MCL clustering generated six clusters with at least two proteins (Fig 4, A). The three largest clusters contained 12, 7, and 4 nodes. In the largest cluster, the nodes with the highest degree included apolipoprotein A1 (n = 14), apolipoprotein A-II (n = 13), apolipoprotein B (n = 13), and alpha-2-HS-glycoprotein (n= 12), all of which were upregulated in the TAA group compared with the TBAD group. Gene ontology for biological process, molecular function, and cellular component had enrichments for lipoprotein and cholesterol processes. The cluster with second highest number of nodes included fibrillin 1, ELN, collagen type 1 alpha 1 chain, and collagen type 4 alpha 2 chain, all of which were upregulated in the TBAD group compared with the TAA group. The top five biological process gene ontology enrichments were collagen-activated tyrosine kinase receptor signaling pathway, aortic valve morphogenesis, protein trimerization, negative regulation of angiogenesis, and negative regulation of transforming growth factor-beta (TGFβ) receptor signaling pathway. Enrichments in molecular function and cellular component also emphasized extracellular matrix, collagen, and integrin processes (Fig 4, B). ELN expression was validated using Western blotting (Fig 2, C). The cluster with four nodes included the hemoglobin subunit beta and hemoglobin subunit zeta proteins. Representative histologic images from all photographs of diseased aortic tissue are shown in Fig 4, C.
      Table IIIDifferentially expressed proteins between thoracic aneurysms and dissections
      Protein symbolProtein nameLog2FCAdjusted P value
      False discovery rate.
      CAM subtype marker
      COL1A1Collagen type 1 alpha 1 chain−2.1.0211
      ELNElastin−1.9.0211
      FBN1Fibrillin 1−1.6.0353S2
      COL4A2Collagen type 4 alpha 2 chain−1.5.0497
      NPNTNephronectin−1.4.0436
      LOXL1Lysyl oxidase like 1−1.3.0369
      LAMB2Laminin subunit beta 2−1.0421
      EMILIN1Elastin micrifibril interfacer 1−1.343
      FUCA1Alpha-L-fucosidase 11.0394
      ECH1Enoyl-coenzyme hydratase 11.0369
      GSH1Glutamine cysteine ligase1.228
      APOA2Apolipoprotein A-II1.1.0344S1
      LAP3Leucine aminopeptidase 31.1.0228
      A1ATAlpha-1 antitrypsin1.1.0244
      RBP4Retinol binding protein 41.1.0498
      FETUAAlpha-2-HS-glycoprotein1.1.0228
      CA2Carbonic anhydrase 21.1.0394S3
      IGJImmunoglobulin J polypeptide1.1.0435S1
      SERPINA7Serpin family A member 71.2.03S1
      APODApolipoprotein D1.3.0244
      HBBHemoglobin subunit beta1.3.0344S3
      APOL1Apolipoprotein L11.4.0369
      HBAHemoglobin subunit alpha1.4.0316S3
      CA1Carbonic anhydrase 11.4.0211S3
      PRTGProtogenin1.5.0369S3
      TNR6CTrinucleotide repeat containing adaptor 6C1.5.0435
      APOC2Apolipoprotein C-II1.6.042
      ADGRF1Adhesion G protein-coupled receptor F11.6.0228S3
      APOC3Apolipoprotein C-III1.6.0228
      IGKV3D-15Immunoglobulin kappa variable 3D-151.6.0344S1
      APOBApolipoprotein B1.6.0211
      HKDC1Hexokinase domain containing 11.7.0435
      HBAZHemoglobin subunit zeta1.7.0376S3
      KANL3KAT8 regulatory NSL complex subunit 31.7.0228S3
      PGS2Decorin1.8.0211
      EIF4G3Eukaryotic translation initiation factor 41.8.0344S1
      CYP27B1Cytochrome p450 family 27 subfamily B member 11.8.0368
      ERC2ELKs/RAB6-interacting/CAST family member 21.9.0344
      APOA1Apolipoprotein A12.0183S1
      IGLL5Immunoglobulin lambda like polypeptide 52.0228S1
      IDNKGluconokinase2.6.0183S3
      HSF1Heat shock transcription factor 12.6.0353S3
      CAM, Convex analysis of mixtures; Log2FC, log2 fold change.
      a False discovery rate.
      Figure thumbnail gr3
      Fig 3Thoracic aneurysms and dissections have a unique set of differentially expressed proteins. A, Heat map of the 43 differentially expressed proteins between aneurysmal and dissection tissue. Relative expression for each protein shown for aneurysmal, dissection, and aneurysm with dissection tissue, where red indicates a relative increase and blue, a relative decrease. B, Principal component analysis using the 43 differentially expressed proteins segregating the control and aortic disease tissue. PC, Principal component; TAA, thoracic aorta aneurysm; TADA, thoracic aorta dissection and aneurysm; TBAD, type B aortic dissection.
      Figure thumbnail gr4
      Fig 4Aneurysm and dissection tissue have unique biological pathways. A, STRING protein network of differentially expressed proteins between aneurysms and dissection tissue. The two largest clusters are highlighted in red and yellow. Relative expression (average Z-scores for a given protein within each experimental group) of each protein in control (C), aneurysm (A), aneurysm with dissection (AD), and dissection (D) displayed in that order as node bar charts, where orange indicates a relative increased expression and blue, a relative decreased expression. The two largest clusters are highlighted in red and yellow. B, Biological process (Top), molecular function (Middle), and cellular component (Bottom) ontology analysis for the two largest clusters highlighted in A. Red bars indicate the largest cluster and yellow bars, the second largest cluster. C, Histologic staining from representative samples of diseased tissue.

      CAM identifies smooth muscle and inflammatory subtypes

      The CAM approach uses unsupervised deconvolution of heterogeneous expression data (eg, homogenized arterial tissues with multiple cell types contributing to proteomic expression) to estimate detectable subtypes and their component marker proteins.
      • Parker S.J.
      • Chen L.
      • Spivia W.
      • Saylor G.
      • Mao C.
      • Venkatraman V.
      • et al.
      Identification of putative early atherosclerosis biomarkers by unsupervised deconvolution of heterogeneous vascular proteomes.
      The CAM workflow identified the presence of at least six putative expression subtypes (Fig 5, A). Of these, subtypes S2, S4, and S6 had marker proteins that overlapped with the differentially expressed proteins shared among all disease comparisons, and subtypes S1 and S3 had marker proteins overlapping with the differentially expressed proteins between the aneurysm and dissection groups (Tables II and III). The proportion of each subtype present in each sample was also estimated using CAM, and these estimated proportions showed clear trends across the experimental groups that were consistent with the overlap between the subtype marker proteins and differentially expressed proteins. Specifically, subtypes S2 and S6 demonstrated elevated proportions in all three disease groups and subtype S4 demonstrated a clear reduction in the disease groups relative to the control (Fig 5, B). Subtypes S1 and S3 were more elevated in the aneurysm conditions relative to dissection. Gene ontology analysis of the marker proteins for each subtype indicated enrichment of the immune and inflammation pathways in subtype S1, endoplasmic reticulum-related proteins in subtype S2, pathways associated with red blood cells in subtype S3, contractile and cell adhesion pathways in subtype S4, and neutrophil-related pathways in subtype S6 (Fig 5, C). Subtype S5 did not exhibit sufficient pathway enrichment for clear interpretation.
      Figure thumbnail gr5
      Fig 5Convex analysis of mixtures (CAM) identified molecular subtypes for aortic disease. A, Minimum distance length plot generated in CAM for K = 2 to 10 potential sources, with minima indicated for 6 sources. B, Box plot of CAM-estimated subtype proportions present in each of the experimental samples, separated by disease category. C, Gene ontology enrichment analysis of the top representative biological process annotations for each subtype. Subtype 5 was omitted owing to the lack of enriched pathways. ER, Endoplasmic reticulum; TAA, thoracic aorta aneurysm; TADA, thoracic aorta dissection and aneurysm; TBAD, type B aortic dissection.

      Discussion

      Thoracic aortic dissection has continued to be one of the highest causes of morbidity and mortality among the cardiovascular diseases. However, few reliable risk factors are available, with the exception of aortic size.
      • Kim J.B.
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      • et al.
      Risk of rupture or dissection in descending thoracic aortic aneurysm.
      Recent studies, however, have indicated that many descending thoracic aortas will dissect without any evidence of prior aneurysm growth and, of even greater concern, do so at less than the recommended thresholds currently set for surgical intervention.
      • Trimarchi S.
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      • et al.
      Descending aortic diameter of 5.5 cm or greater is not an accurate predictor of acute type B aortic dissection.
      ,
      • Pape L.A.
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      • Oh J.K.
      • O'Gara P.T.
      • Evangelista A.
      • et al.
      Aortic diameter > or = 5.5 cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aortic Dissection (IRAD).
      These clinical findings beg the question of whether dissections with and without an aneurysm represent two different types of diseases. We found at least some differences in the pathways that govern these two diseases, as indicated by the differential protein expression analysis between the TAAs and TBADs. No proteins, however, were significantly altered comparing TADA to TBAD or TAA. This finding was consistent with the CAM results, which showed that within most subtypes TADA was clustered between TBAD and TAA, with the exception of perhaps subtype S1, for which TADA clustered more closely with TAA than with TBAD. The inability to distinguish TADA from TBAD and TAA might have been because TADAs share a signature with both TAA and TBAD or because TADAs represent a mixture of signatures, such that each aorta behaves more like TAA or TBAD. Thus, given the low sample size, the differential expression and CAM were unable to identify significant distinguishing features. We favored the latter theory because the TADAs tended to cluster with either TAA or TBAD using principle component analysis. In addition, we lacked information regarding whether the TADA samples represented atherosclerotic aneurysms that had dissected or dissected tissue that had degenerated into an aneurysm or pseudoaneurysm.
      The results of our analyses have shown that the normal tissue was molecularly different from the pathologic tissue. However, we also sought to determine whether any similarities were present between the different types of pathologic aortas. We found 71 proteins that were similarly differentially expressed between each pathology and normal tissue, representing 66%, 17%, and 21% of the differentially expressed proteins from TADA, TAA, and TBAD, respectively. Clearly, some common features exist among aneurysms at risk of dissection, aneurysms that dissect, and aortas without aneurysms that dissect. A network analysis of these 71 proteins generated one main cluster. THBS1 was at the center of this cluster, with a degree of 15. THBS1 was one of the few upregulated proteins in disease tissue compared with the normal tissue, and prior studies have demonstrated a pathologic role for increased THBS1 expression in both aneurysms and dissections. In the Fbln4SMKO aneurysm mouse model, THBS1 is upregulated and causes disruption of the actin cytoskeleton and ELN-contractile apparatus. Deletion of this gene prevents aneurysm formation.
      • Yamashiro Y.
      • Thang B.Q.
      • Shin S.J.
      • Lino C.A.
      • Nakamura T.
      • Kim J.
      • et al.
      Role of thrombospondin-1 in mechanotransduction and development of thoracic aortic aneurysm in mouse and humans.
      In humans, THBS1 is upregulated in the aortas and plasma of patients with acute dissection and might play a role in smooth muscle cell apoptosis and macrophage activation.
      • Zeng T.
      • Yuan J.
      • Gan J.
      • Liu Y.
      • Shi L.
      • Lu Z.
      • et al.
      Thrombospondin 1 is increased in the aorta and plasma of patients with acute aortic dissection.
      Thus, THBS1 might be a useful diagnostic marker for all types of aortic degeneration. In addition, THBS1 enzyme-linked immunosorbent assay kits are commercially available and have been used by others to easily detect plasma levels in patients, indicating the practicality of using this protein as a biomarker.
      • Choi K.Y.
      • Kim D.B.
      • Kim M.J.
      • Kwon B.J.
      • Chang S.Y.
      • Jang S.W.
      • et al.
      Higher plasma thrombospondin-1 levels in patients with coronary artery disease and diabetes mellitus.
      Further work in animal models is needed to determine whether THBS1 can be used to predict aneurysms at risk of dissection.
      The proteome we analyzed represents a homogenate of multiple underlying cell types. Unsupervised deconvolution by CAM provided provisional insight into how the proteome is organized in terms of the molecular or cellular subtypes. When the proteins in our CAM were screened for those with the gene ontology annotation “contractile,” and their expression was compared across the six subtypes, subtypes S2 and S4 demonstrated a clear enrichment for contractile protein expression (Supplementary Fig). Nevertheless, subtype S4 was more abundant in normal tissue, and subtype S2 was more abundant in diseased tissue. Recent studies using single cell–based omics have shown different populations of smooth muscle cells with unique genetic signatures.
      • Li Y.
      • Ren P.
      • Dawson A.
      • Vasquez H.G.
      • Ageedi W.
      • Zhang C.
      • et al.
      Single-cell transcriptome analysis reveals dynamic cell populations and differential gene expression patterns in control and aneurysmal human aortic tissue.
      Subtypes S4 and S2 could represent two such unique populations of smooth muscle cells, and the shift in abundance of these two populations could be a phenotype of aortic disease. Infiltration of different cells, such as immune cells, from the blood also likely occurs. Subtypes S1 and S6 were enhanced in disease tissue compared with the control tissue, and this group was enriched in inflammatory proteins. Although subtype S6 was enriched for markers of neutrophils and was predicted to be upregulated in all three disease states, subtype S1 was marked by monocyte and IgG (eg, B cell) proteins, and its upregulation appeared limited to the cases with aneurysms. This suggests differences could exist in the nature of the inflammatory involvement between TAA and TBAD, favoring unique involvement of monocyte and B cell infiltration in the etiology of aneurysms but not dissections. Alternatively, this could reflect shifting proportions due to the loss of smooth muscle cells without a large amount of additional infiltration or, even, phenotype switching of smooth muscle cells to phagocytic or monocyte-like cells.
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      • Foo R.
      • et al.
      Role of vascular smooth muscle cell plasticity and interactions in vessel wall inflammation.
      This will require significant additional study but presents one intriguing novel hypothesis to explain the differences between these two disease presentations in the descending aorta.
      We also uncovered 42 differentially expressed proteins that could distinguish TAA from TBAD. These proteins were enriched in many canonical genes associated with aneurysms and dissections.
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      • et al.
      Familial thoracic aortic aneurysms and dissections—incidence, modes of inheritance, and phenotypic patterns.
      ,
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      Genetics of thoracic and abdominal aortic diseases.
      Only eight proteins were upregulated in the TBAD cohort compared with the TAA group, and seven of these eight genes formed the second largest cluster in the network of all dysregulated proteins. The central node of this cluster was fibrillin 1, and the network was enriched in many processes linked to dissection, including collagen, integrin, and TGFβ signaling.
      • Dietz H.C.
      • Pyeritz R.E.
      Mutations in the human gene for fibrillin-1 (FBN1) in the Marfan syndrome and related disorders.
      ,
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      • Johnson R.J.
      • et al.
      Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1.
      These findings highlight the delicate balance governed by TGFβ signaling in maintaining the exact amount of extracellular matrix (ECM) content. Upregulation of TFGβ signaling can lead to both ECM destruction and deposition. Our findings suggest that aortas that dissect without aneurysm formation might have fragile media owing to excessive ECM composition and that aneurysms will be marked by a paucity of at least certain ECM components.
      • Jones J.A.
      • Spinale F.G.
      • Ikonomidis J.S.
      Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis.
      These findings are consistent with those from previous studies, which have shown that patients with thoracic aortic dissection tend to have increased collagen content and patients with aneurysms tend to have a loss of ELN and collagen.
      • Wang X.
      • LeMaire S.A.
      • Chen L.
      • Shen Y.H.
      • Gan Y.
      • Bartsch H.
      • et al.
      Increased collagen deposition and elevated expression of connective tissue growth factor in human thoracic aortic dissection.
      Atherosclerosis can also be an important initiator of aneurysm formation. The largest cluster in the network of differentially expressed proteins contained 12 proteins, all upregulated in TAA compared with TBAD. Of these 12 proteins, 7 were apolipoproteins. Previous studies have demonstrated upregulation of apolipoproteins in thoracic aortic aneurysm samples compared with normal aortas.
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      • Satoh K.
      • Maniwa T.
      • Tanaka T.
      • Okunishi H.
      • Oda T.
      Proteomic comparison between abdominal and thoracic aortic aneurysms.
      This finding was also consistent with the CAM results, because subtype S1, which is enriched in cholesterol and inflammatory proteins, was enhanced in TAAs compared with TBADs. This could signify a shift toward more inflammatory cells in aneurysm tissue compared with dissected tissue, which is known to occur after TGFβ-mediated metalloproteinase destruction of ECM.
      • Jana S.
      • Hu M.
      • Shen M.
      • Kassiri Z.
      Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm.
      Finally, the third largest cluster included hemoglobin proteins, which have also been shown to be upregulated in proteomic studies of abdominal and thoracic aortas. Similarly, subtype 3 in the CAM profile, which was enriched in red blood cell markers, was enhanced in aneurysmal tissue. The significance of this trend is unclear but might represent mural thrombus, a stress response and upregulation of fetal proteins, a response to hypoxia locally, or contamination from the destruction of red blood cells in the turbulent flow that occurs in aneurysms.
      • Saha D.
      • Patgaonkar M.
      • Shroff A.
      • Ayyar K.
      • Bashir T.
      • Reddy K.V.R.
      Hemoglobin expression in nonerythroid cells: novel or ubiquitous?.
      The utility of using these targets to predict acute dissection can be elucidated from experimental serum proteomics in animal models of dissection with and without aneurysms and prospective proteomic analysis of patients with and without aneurysms.
      The present study had some limitations. First, we were unable to obtain significant background information such as the comorbidities of the donor control patients. Furthermore, the proportion of white patients was greater in the control group than in the disease groups (P = .03, χ2 analysis), although we did not observe significant differences in the differential protein analysis when race was added as a covariate (data not shown). Also, the donor control patients were slightly younger than the patients with aortic disease, although the difference was not statistically significant (P = .18, analysis of variance). In addition, although no significant sex differences were present between all groups in our study (P = .78, χ2 analysis), men were overrepresented. As such, additional studies with female patients will be important to uncover potential sex differences. Finally, for the most part, TBAD and TADA represent aortic dissections that do not degenerate to aneurysms and those that do degenerate to aneurysms, respectively. However, we did not have sufficient clinical information to fully rule out a sample in the TADA group representing an aneurysm that had subsequently dissected. We also failed to detect significant differences between TADA and TBAD and TADA and TAA. This was likely in part due to the heterogeneous nature of TADA patients and the low sample size. Nevertheless, we have uncovered significant candidate proteins that could be used as biomarkers for degenerative diseases of the descending aorta and the risk of acute dissection pending serum validation.

      Conclusions

      We have presented a novel comparison of proteomic profiles from normal human descending thoracic aorta and tissue with aneurysmal growth, dissection, and aneurysm with dissection. Although most of the currently available proteomic profiles of the human aorta are from the ascending thoracic and abdominal segments, we have added profiles from the descending thoracic aorta. Because patients with diseases of the descending aorta have different treatment and diagnostic algorithms compared with diseases of other segments, we sought to share some of the protein signatures that could help explain these clinical differences. We were able to identify THBS1 as potential biomarker of degenerative diseases of the aorta such as aneurysms and dissections. A comparison between patients with TAA and TBAD highlighted the crucial balance of TGFβ signaling in ECM deposition and destruction and provided a potential mechanism for how this pathway could be responsible for two different types of pathology that can lead to the same clinical outcome, namely dissection.

      Author Contributions

      Conception and design: LS, DG, DM, DH, AA, SP
      Analysis and interpretation: LS, AO, DG, DM, DT, RH, DH, YW, AA, SP
      Data collection: DG, DM, AA, SP
      Writing the article: LS, SP
      Critical revision of the article: LS, AO, DG, DM, DT, RH, DH, YW, AA, SP
      Final approval of the article: LS, AO, DG, DM, DT, RH, DH, YW, AA, SP
      Statistical analysis: LS, SP
      Obtained funding: DM, DH, AA, SP
      Overall responsibility: SP
      We are grateful for the support of the Cedars-Sinai Proteomics and Metabolomics Core Facility, including Rakhi Pandey and Ron Holewinski, for technical support in MS data acquisition. We are also deeply grateful to the Genomic and Proteomic Architecture of Atherosclerosis project leadership for access to the control thoracic aortic tissue and the UTHealth SCCOR biorepository for collection, storage, and release of the aortic aneurysm and dissection specimens.

      Appendix

      Figure thumbnail fx1
      Supplementary FigConvex analysis of mixtures (CAM) showing that subtypes 2 and 4 comprised the highest percentage of expressed contractile proteins. Heatmap displaying the proportion of the expression of all CAM genes with the gene ontology annotation “contractile” attributed to each subtype.
      Supplementary Table ICause of death in control tissue
      Cause of death%
      Drug overdose43.50
      Cardiovascular34.80
      Asphyxia8.70
      Trauma6.50
      Pneumonia4.30
      Other2.20
      Supplementary Table IIComplete differential expression analysis between aortic pathologies and normal aorta
      GeneLog2FC TAA/normalAdjusted P value
      False discovery rate.
      Log2FC TBAD/normalAdjusted P value
      False discovery rate.
      Log2FC TADA/normalAdjusted P value
      False discovery rate.
      A1BG−0.2.548−0.9.001−0.2.827
      A2M0.6.087−0.3.4870.8.203
      AAMDC−1.2<.001−1.004−0.5.458
      AARS10.2.651−0.2.6720.1.951
      ABCA13−1.4<.001−0.9.045−0.5.59
      ABCCB−0.5.332−0.4.5830.3.829
      ABCD1−0.5.381−0.9.1410.2.914
      ABCF10.5.323−1.1.040.7.469
      ABHD14B−0.7.029−1.2.003−0.3.678
      ABI3BP−1.3<.001−0.9.008−0.8.147
      ACAA10.1.872−0.5.295−0.6.538
      ACAA2−0.6.109−1.1.017−1.157
      ACADM−0.3.418−0.6.118−0.7.209
      ACADVL0.2.563−0.6.045−0.2.759
      ACAN−2.7<.001−1.7.001−2.2.002
      ACAT1−1.5<.001−1.8<.001−1.3.01
      ACAT2−0.2.737−0.7.074−0.1.949
      ACLY0.2.5930.1.955−0.2.851
      ACO1−0.8.003−0.9.01−0.5.369
      ACO2−0.3.444−0.7.034−0.5.444
      ACOT90.1.864−0.1.8850.4.582
      ACP1−0.7.004−1.4<.001−0.5.39
      ACSF2−1.2.009−0.8.2040.2.933
      ACSL1−0.3.585−0.4.556−0.8.369
      ACTA1−1.001−1.007−0.5.458
      ACTBL2−1.1<.001−0.5.127−0.4.504
      ACTN1−0.7.002−0.2.53−0.1.879
      ACTN2−1.4<.001−1.5<.001−1.02
      ACTN30.2.829−0.6.425−0.3.84
      ACTN4−0.9.001−0.7.049−0.3.754
      ACTR100.2.5540.2.6410.6.276
      ACTR1A−0.3.467−0.8.022−0.2.829
      ACTR2−0.1.850.2.4520.1.967
      ACTR3−0.1.735−0.1.959−0.1.991
      ACYP2−1.1.002−1.3.006−1.188
      ADAM17−1.004−0.8.073−0.2.866
      ADAMTS2−0.8.153−2.6<.001−1.2.242
      ADAMTSL1−1.1.001−0.2.742−0.5.498
      ADAMTSL20.3.7651.4.0691.1.382
      ADAMTSL4−0.8.024−0.3.602−0.2.827
      ADARB10.1.959−0.3.5180.8.167
      ADD1−0.3.604−1.038−0.7.364
      ADD30.1.938−0.2.723−0.1.924
      ADGRF10.8.025−0.9.068−0.3.787
      ADH1B−0.9.061−0.8.21−0.2.893
      ADH5−0.9.001−1.1.002−0.5.369
      ADIPOQ−0.5.225−0.2.6830.8.315
      ADIRF−0.9.028−0.7.213−0.3.829
      ADSL0.3.2140.1.893−0.1.999
      ADSS1−0.3.5940.9.0510.9.245
      AEBP10.3.3490.3.5420.4.613
      AFM0.3.459−0.8.0240.5.495
      AGL−0.3.389−0.4.410.1.917
      AGRN−0.7.02−0.9.025−0.5.501
      AGT0.1.965−0.8.020.2.767
      AHCY0.1.912−0.4.181−0.1.988
      AHCYL10.1.942−0.4.2590.1.988
      AHNAK−0.6.013−0.5.089−0.7.179
      AHSG−0.4.144−1.5<.001−0.4.449
      AIFM1−0.2.606−0.6.059−0.5.283
      AIMP20.2.4830.2.7230.3.681
      AIP−0.5.149−0.3.525−0.1.939
      AK1−0.8<.001−0.8.001−0.7.028
      AK2−0.7.052−1.6.001−1.173
      AK30.1.932−0.4.375−0.5.46
      AK4−1.1.001−0.6.15−0.7.363
      AK70.7.109−0.5.402−0.2.87
      AKAP120.1.806−0.4.3950.2.847
      AKR1A1−0.4.129−1.003−0.1.879
      AKR1B1−0.2.516−0.8.002−0.2.713
      AKR7A20.1.806−0.7.1−0.4.666
      AKR7A31.2.0430.8.3641.48
      ALAD−0.1.916−0.7.076−0.2.88
      ALB−0.2.749−1.2.0030.1.986
      ALCAM−0.1.7940.4.2910.5.521
      ALDH1A1−0.9<.001−1.1<.001−0.6.171
      ALDH1B1−1.7<.001−1.4.001−1.2.031
      ALDH1L1−1.1<.001−1.2.001−0.9.097
      ALDH2−1.001−1.2.001−0.7.241
      ALDH6A1−1.1.001−1.2.004−0.7.352
      ALDH7A1−1.001−1.2.001−0.6.283
      ALDH9A1−0.6.032−1.006−0.3.676
      ALDOA−0.4.046−0.4.11−0.2.746
      ALDOC−0.5.02−0.3.360.1.957
      ALMS10.7.0210.2.780.6.423
      ALOX15B−0.7.057−0.9.053−0.6.45
      AMBP−0.3.338−0.7.051−0.2.851
      AMIGO21.2.0060.7.2411.1.18
      AMN−1.9<.001−2.002−1.7.071
      AMPD20.5.0990.7.1030.4.602
      ANG−0.4.339−0.3.460.1.986
      ANGPTL2−0.7.046−0.6.204−0.5.626
      ANK11.3<.0010.4.3060.4.614
      ANKRD31−2.2<.001−1.9.006−1.406
      ANKS3−2.3.001−1.7.034−1.2.384
      ANP32B−0.6.221−0.8.179−0.1.999
      ANTXR1−0.2.7420.5.208−0.3.772
      ANXA1−0.4.054−0.2.584−0.2.721
      ANXA11−0.9<.001−0.6.032−0.8.05
      ANXA2−0.4.176−0.4.202−0.2.762
      ANXA3−0.3.5310.1.90.2.784
      ANXA4−1.3<.001−1.001−1.012
      ANXA5−1.5<.001−1.5<.001−1.2.012
      ANXA6−1<.001−0.7.019−0.7.137
      ANXA7−0.5.027−0.4.189−0.5.217
      AOC3−1.4.001−0.3.65−0.3.819
      AP1B10.1.937−0.4.15−0.5.264
      AP2A1−0.2.536−0.3.5470.1.998
      AP2A2−0.2.69−0.6.334−0.4.713
      AP2B1−0.4.18−0.8.024−0.5.364
      AP2M10.3.4990.1.9460.4.637
      AP3B10.4.188−0.2.7470.2.807
      AP3B2−0.7.126−0.3.630.2.894
      AP3S1−0.3.552−0.2.8010.1.959
      APCS−1.9<.001−2.1<.001−1.3.059
      APEH−0.3.493−0.9.045−0.7.293
      APEX10.2.5760.7.1060.7.266
      APMAP0.6.0020.5.0380.5.262
      APOA1−0.3.287−1.3.001−0.3.729
      APOA2−0.1.828−1.2.001−0.2.83
      APOA4−0.9<.001−1.3<.001−1.023
      APOB0.8.021−0.9.050.7.356
      APOC1−0.1.964−0.8.07−0.2.844
      APOC20.4.372−1.2.0170.6.584
      APOC30.1.877−1.6.0010.3.792
      APOD0.7.012−0.6.1270.5.432
      APOE0.5.144−0.6.2040.5.468
      APOF0.1.905−0.4.27−0.1.889
      APOH−0.9.001−1.1.001−0.7.165
      APOL10.7.061−0.8.0840.7.362
      APOM0.8.004−0.2.6270.5.378
      APP−1.9<.001−1.8<.001−1.9.001
      APPL1−0.1.941−0.1.862−0.2.773
      APRT0.3.277−0.6.0530.2.762
      AQP1−0.5.114−0.6.1220.1.979
      ARCN10.3.217−0.1.944−0.1.941
      ARF40.7.010.3.4550.7.244
      ARF5−0.2.5540.5.223−0.1.998
      ARFIP1−1<.001−1.1.001−0.7.154
      ARG1−1.9<.001−1.1.012−1.7.01
      ARHGAP1−0.5.003−0.6.009−0.2.714
      ARHGAP11A1.4.0091.1741.5.147
      ARHGAP31−0.8.155−1.1740.5.725
      ARHGAP40−0.6.08−0.8.055−0.3.729
      ARHGAP9−1.1.081−1.1.1870.2.907
      ARHGDIA−0.7.001−0.8.002−0.3.48
      ARHGDIB0.6.0040.5.090.3.692
      ARHGEF37−2.1<.001−1.5.024−0.9.432
      ARL6IP50.2.4380.4.0950.3.521
      ARL8B−0.8.206−0.2.872−0.1.995
      ARMC5−0.1.909−0.5.642−0.7.729
      ARNTL2−1.042−1.6.012−1.369
      ARPC1A−0.7.009−0.6.056−0.3.656
      ARPC1B0.4.0640.4.1510.3.521
      ARPC20.2.5480.2.6050.2.768
      ARPC30.1.847−0.1.813−0.1.959
      ARPC40.2.408−0.2.6510.2.679
      ARPC5−0.4.279−1.1.003−0.4.656
      ARPC5L−1.2.001−1.6.001−0.8.294
      ASAH10.2.604−0.6.058.1.988
      ASNA−0.3.336−0.7.021−0.2.777
      ASPH−0.5.241−0.7.191−0.8.412
      ASPN1.3.001−0.1.9461.2.118
      ASS1−1.1.001−1.013−0.6.46
      ATAD2B0.5.3180.2.8471.304
      ATIC0.1.747−0.2.7010.3.676
      ATL3−0.2.5240.3.5230.2.829
      ATOX1−1.001−1.5.001−0.9.142
      ATP1A10.4.2380.6.1890.6.46
      ATP2A2−0.3.5420.3.593−0.1.994
      ATP2B4−0.3.4790.1.955−0.3.789
      ATP5F1A−0.3.138−0.5.032−0.3.365
      ATP5F1B−0.4.091−1.002−0.6.283
      ATP5F1C0.1.8−0.5.067−0.1.912
      ATP5F1D−0.3.323−0.7.026−0.3.555
      ATP5ME−1.002−0.8.045−0.3.75
      ATP5MF1.1.0261.1070.9.385
      ATP5MG−0.7.046−0.9.048−0.4.676
      ATP5PB−0.2.586−0.7.110.1.944
      ATP5PD−0.7.002−0.9.003−0.6.177
      ATP5PF−0.5.105−1.1.005−0.4.546
      ATP5PO−0.2.427−0.8.01−0.4.492
      ATP6V1A0.1.937−0.7.043−0.2.864
      ATP6V1B2−0.1.924−0.7.055−0.2.778
      ATP6V1E10.5.071−0.3.3550.2.771
      ATP6V1H0.3.25−0.2.619−0.1.994
      ATP8A1−0.2.875−0.7.395−0.2.907
      ATR−0.3.4140.4.4320.8.255
      AXIN1−0.1.916−0.3.8541.1.562
      AZGP1−0.5.135−1.3.001−0.3.734
      B2M0.4.153−0.5.0970.2.731
      BAG2−1.1.001−0.4.374−0.6.446
      BANF1−1.6<.001−2.1<.001−1.1.132
      BASP10.1.8810.3.4340.2.792
      BBS90.2.550.4.2850.4.498
      BCAM−1.2<.001−0.5.202−0.4.589
      BCAP310.8.0960.4.5551.1.212
      BCL100.4.3331.0230.5.488
      BDH2−1.2.003−1.2.02−0.9.309
      BGN−1.3.001−1.3.011−0.8.345
      BLM−0.1.979−0.6.4490.3.85
      BLMH0.5.266−0.2.817−0.2.869
      BLVRA0.2.604−0.1.7450.1.967
      BLVRB0.5.06−0.4.2040.3.589
      BNC2−0.3.46−0.3.4760.1.939
      BPGM0.6.123−0.5.3610.1.939
      BPNT1−1.4.001−1.7.001−1.4.052
      BRK1−0.1.971−0.2.7310.1.959
      BSG−1.0520.1.9390.2.917
      C11orf54−1.4<.001−1.6<.001−1.2.03
      C11orf96−1.3.002−0.6.334−0.2.889
      C1orf198−0.2.657−0.4.347−0.1.919
      C1QA−1.2.003−0.6.335−0.4.73
      C1QB−0.7.07−0.4.549−0.4.677
      C1QC−0.9.032−0.8.165−0.5.677
      C1R0.2.6040.1.9240.2.841
      C1S0.3.207−0.1.960.4.431
      C2−0.5.16−0.7.1560.4.715
      C22orf23−0.4.410.1.9660.4.761
      C2orf78−1.6.001−0.5.398−1.7.034
      C30.1.957−0.6.0430.2.762
      C4A0.2.537−0.1.9010.6.315
      C4B0.4.196−0.1.9620.4.542
      C4BPA0.3.342−0.5.1790.3.668
      C4BPB0.8.038−0.6.1960.6.475
      C50.1.965−0.4.240.2.781
      C6−0.4.109−0.4.27−0.1.883
      C7−0.6.031−0.5.213−0.4.582
      C8A−0.3.276−0.1.8540.3.655
      C8B0.1.899−0.1.8250.5.487
      C8G−0.5.129−0.9.019−0.2.871
      C8orf742<.0012.9<.0012.013
      C9−0.6.032−0.5.219−0.3.676
      CA10.6.06−0.9.019−0.1.997
      CA123−1.9.001−0.9.211−2.1.032
      CA20.3.413−0.9.014−0.4.649
      CA3−1.8<.001−2.4<.001−2.10.004
      CAB39−0.3.561−0.4.443−0.4.677
      CACNA2D1−1.1.001−0.8.054−0.7.345
      CACYBP−0.3.336−0.3.434−0.4.593
      CALD1−1.1.002−0.9.045−0.6.446
      CALR−0.1.873−0.1.820.1.949
      CALU−0.3.272−0.5.06−0.6.194
      CAMK2G−0.9.0040.2.785−0.5.46
      CAND10.4.1750.4.2180.8.15
      CANX0.6.0030.6.0070.5.153
      CAP1−0.6<.001−0.8.001−0.7.025
      CAP2−1.4<.001−1.1.005−0.9.129
      CAPG0.3.413−0.5.17−0.3.759
      CAPN10.1.872−0.1.7080.1.903
      CAPN2−0.6.011−0.4.196−0.1.967
      CAPNS1−0.6.002−0.7.003−0.5.206
      CAPZA10.6.010.1.8720.2.851
      CAPZA2−0.7.002−1.1.001−0.6.177
      CAPZB0.1.9120.2.4310.2.783
      CARD101.6.0010.7.2890.6.653
      CASKIN2−0.8.024−0.9.053−0.5.553
      CASP8−0.4.2770.2.7590.3.762
      CAST−0.1.762−0.6.036−0.4.481
      CAT0.5.038−0.1.9240.2.807
      CATSPERG−2.8<.001−2.5<.001−1.7.048
      CAV1−0.5.2790.3.6060.3.762
      CAV20.6.0631.0081.2.031
      CAVIN1−1.1.002−0.9.053−0.3.771
      CAVIN20.9.0020.5.1410.2.783
      CAVIN3−1.002−0.5.328−0.2.881
      CBLN2−0.7.012−0.9.009−0.3.754
      CBR1−0.6.022−0.9.008−0.3.691
      CBR3−1.3.002−1.1.045−1.233
      CCAR1−0.4.467−1.8.0010.1.967
      CCDC158−1.1.007−0.9.107−0.4.739
      CCDC194−1.5.001−0.6.252−0.7.444
      CCDC253.7.0012.2.1160.8.771
      CCDC6−1.5<.001−1.2.001−0.6.272
      CCDC690.1.9120.7.3360.6.677
      CCDC800.8.0040.6.1040.7.281
      CCN3−1.9<.001−1.9<.001−1.5.021
      CCS−0.5.199−1.1.022−1.1.153
      CCT2−0.1.746−0.4.119−0.2.725
      CCT3−0.1.856−0.4.2940.1.954
      CCT40.5.0170.5.0540.4.309
      CCT50.1.951−0.3.452−0.2.839
      CCT6A−0.2.531−0.1.916−0.2.77
      CCT70.5.0270.3.3740.4.422
      CCT80.2.586−0.2.7240.1.939
      CD109−0.2.774−0.2.7540.4.621
      CD140.7.1070.3.5680.5.634
      CD151−0.4.3010.1.8920.1.96
      CD1631<.0010.9.010.8.137
      CD34−0.9.003−0.8.055−0.2.81
      CD44−0.2.3220.1.9390.1.946
      CD470.1.9660.1.8890.2.81
      CD59−0.2.7460.2.6750.4.668
      CD5L0.1.873−1.0110.2.885
      CD81−0.4.431−0.4.5210.1.946
      CD9−0.1.8610.1.8540.4.677
      CD97−1.5<.001−1.8<.001−1.60.019
      CD99−0.4.374−1.2.005−0.3.77
      CDC25C−1.034−1.8.002−1.3.138
      CDC37−0.1.7890.3.3910.2.825
      CDC420.5.0170.6.0390.6.172
      CDC5L−0.2.759−1.2.0020.3.719
      CDH1−0.6.18−0.4.533−0.4.762
      CDH13−0.9.007−0.3.6060.3.734
      CDHR30.5.368−0.5.4010.6.536
      CDK5RAP3−0.1.87−0.3.607−0.4.729
      CDKN2AIP1.1.0690.4.6451.5.206
      CELSR3−3.3<.001−2.3.002−3.2.002
      CENPE−1.2.007−0.6.327−0.1.972
      CES1−1.3<.001−0.4.349−0.4.587
      CFB−0.3.483−0.6.1270.4.648
      CFD−1.3<.001−1.9<.001−1.066
      CFH0.1.899−0.5.0720.3.545
      CFHR1−0.7.103−0.8.1220.2.899
      CFHR2−0.3.312−0.5.1560.2.792
      CFHR5−0.1.837−0.3.6540.7.36
      CFI−0.1.811−1.0060.3.659
      CFL1−0.6.001−0.7.002−0.5.151
      CFL2−1.8<.001−1.5.001−0.9.18
      CFP−1.8<.001−1.4<.001−1.5.004
      CHCHD3−0.8.028−0.3.632−0.3.734
      CHD80.8<.0010.6.0240.6.124
      CHMP2A−0.2.5860.4.418−0.3.704
      CHMP4B−0.9.001−0.9.017−0.7.237
      CHST14−1.1.008−0.1.903−0.4.714
      CHTF18−2.3.001−3.3<.001−1.5.234
      CILP2−0.3.6530.1.981.5.084
      CIRBP−0.2.742−0.8.072−0.5.611
      CISD10.4.2120.3.5610.4.659
      CKAP20.5.055−0.2.6540.6.219
      CKAP40.5.1170.3.5830.3.762
      CKB−1.8<.001−2<.001−1.4.01
      CKM−1.6<.001−1.6<.001−2<.001
      CLEC11A0.5.218−0.2.848−0.2.907
      CLEC3B−0.70.012−1.1.002−0.7.248
      CLIC10.5.0080.2.6090.2.612
      CLIC4−0.8.008−0.9.018−0.3.687
      CLTA0.7.0380.6.1840.1.979
      CLTB−0.6.041−0.7.055−0.4.582
      CLTC0.4.1330.3.3580.4.422
      CLU−0.8.004−1.1.004−0.6.308
      CMA10.2.64−0.3.410.1.944
      CMBL−1.1.001−1.1.004−0.7.291
      CMPK1−0.6.007−0.9.002−0.3.639
      CMYA50.2.812−1.1.0270.1.976
      CN166−0.5.416−0.8.215−0.4.773
      CNBP−0.3.55−0.4.467−0.4.681
      CNDP2−0.5.105−0.9.006−0.2.787
      CNN1−2.3<.001−1.6.004−1.2.182
      CNN20.1.7660.1.8370.2.762
      CNN3−0.2.774−0.3.6450.3.79
      CNPY20.3.482−0.4.331−0.1.956
      CNRIP1−0.7.001−1.001−0.7.085
      CNTN1−0.9.001−0.7.033−0.5.377
      COASY0.4.37−0.4.5180.3.771
      COG5−0.4.0550.2.492−0.1.881
      COL12A10.8.0290.2.810.5.656
      COL14A1−0.8.025−0.4.395−0.3.782
      COL15A1−0.4.162−0.6.092−0.4.558
      COL18A1−2<.001−1.5.001−1.4.031
      COL1A10.7.1771.6.0091.7.067
      COL1A20.4.4931.3.0241.3.149
      COL21A1−0.4.521.9.0021.4.115
      COL3A11.2.0252.6.0012.4.012
      COL4A1−1.6<.001−0.4.396−0.6.503
      COL4A2−1.5<.0010.1.987−0.2.851
      COL4A3−1.7<.001−0.5.354−0.8.329
      COL6A1−0.2.7020.3.4730.2.881
      COL6A2−0.1.9520.6.1710.4.687
      COL6A30.2.709−0.2.7260.4.538
      COL7A10.2.678−1.1.038−0.3.83
      COL8A1−0.6.2691.1.0740.8.412
      COLGALT10.2.7370.1.840.4.582
      COMT−0.3.441−0.3.542−0.2.879
      COPA0.9.0050.9.020.8.237
      COPB10.9.0040.7.0790.5.533
      COPB21.0030.6.1740.9.177
      COPG10.5.0880.4.3220.2.845
      COPS50.5.0520.3.530.3.743
      COPS6−0.7.031−0.5.321−0.3.762
      CORO1A1.1.0011.0130.8.25
      CORO1B−0.5.08−0.7.028−0.3.713
      CORO1C−0.4.121−0.4.234−0.1.957
      COTL10.4.147−0.1.9280.2.773
      COX4I1−0.3.61−0.6.337−0.5.665
      COX5A−0.9.001−1.5<.001−1.1.05
      COX5B−0.1.792−0.9.013−0.7.276
      COX6B1−0.7.042−1.021−0.3.797
      COX6C0.3.7040.4.536−0.4.771
      COX7A20.2.679−0.6.202−0.4.666
      CP0.1.871−0.4.240.4.475
      CPA30.3.571−0.6.319−0.5.647
      CPB20.8.0030.4.2370.6.314
      CPNE1−0.7.006−0.3.442−0.5.407
      CPNE3−0.5.1790.3.614−0.3.734
      CPPED1−0.5.181−0.8.064−0.1.954
      CPQ−1.001−1.003−0.7.231
      CPXM2−1.3.001−1.1.02−0.8.362
      CREG1−1.019−1.051−0.5.626
      CRIP11.9.0711.1.4281.5.536
      CRIP2−0.9.027−0.5.407−0.2.852
      CRK−1.1.004−1.042−0.7.379
      CRKL−0.4.244−0.6.0860.1.939
      CRLF1−0.7.058−1.026−1.126
      CRP0.9.0530.4.5751.7.055
      CRYAB−2<.001−1.6<.001−1.2.04
      CRYL1−1.5<.001−1.3.006−0.8.315
      CRYZ−1.1<.001−1.3<.001−0.7.147
      CS0.3.2260.1.811−0.1.899
      CSDE1−1.1.051−0.8.2591.431
      CSK0.9.0040.4.3170.5.485
      CSPG4−1.4<.001−1.003−0.9.084
      CSPG5−1.3.014−1.1.118−0.3.823
      CSRP1−1.4.001−1.1.019−0.6.498
      CSRP2−0.8.051−0.4.5210.4.712
      CSTB−0.5.022−0.8.002−0.2.735
      CTGF1.2.0020.4.4450.4.725
      CTHRC1−0.1.839−0.9.013−1.056
      CTNNA10.8.2330.6.4510.6.731
      CTNND10.7.0210.3.5230.4.542
      CTPS1−0.7.027−0.6.127−0.5.58
      CTSB0.5.144−0.1.9230.3.78
      CTSC0.7.019−0.2.7870.8.23
      CTSD0.2.455−0.5.1180.2.815
      CTSF−1.2.001−0.9.034−0.5.503
      CTSG1.0021.2.0080.5.562
      CTSZ0.1.946−0.1.765−0.2.815
      CTTN0.3.4510.5.1430.2.771
      CUL90.3.773−1.5.073−0.1.956
      CUTA−1.4<.001−1.7<.001−0.9.161
      CXCL120.1.9650.3.6770.2.88
      CXCL16−1.3.003−1.3.02−0.8.422
      CYB5R10.7.0570.6.210.7.349
      CYB5R30.1.949−0.2.7650.4.668
      CYBRD10.8.0790.4.5971.6.058
      CYCS0.3.383−0.4.335−0.3.772
      CYFIP10.4.1490.5.2210.5.369
      CYP20A10.2.873−0.5.6830.4.852
      CYP27B11.028−0.9.1290.4.762
      CYP2C80.2.8890.1.9490.5.771
      DAAM2−0.3.676−0.8.354−0.9.477
      DAD11.2.0171.6.0091.5.125
      DAG1−1.6<.001−1.1.006−0.8.198
      DARS10.3.2130.5.1190.3.656
      DBI−1.2<.001−1.001−0.8.067
      DBN1−0.5.11−0.8.018−0.7.225
      DBNL−0.2.418−0.8.006−0.2.725
      DCN−1.1.003−2.9<.001−2.4.001
      DCPS0.1.965−0.7.028−0.2.817
      DCTN1−0.4.218−0.3.433−0.4.619
      DCTN2−0.6.013−0.8.005−0.5.318
      DCTN3−0.7.025−0.7.067−0.3.679
      DDAH1−2<.001−2.001−1.5.056
      DDAH2−1<.001−1.001−0.5.281
      DDB10.3.3590.1.9280.5.561
      DDOST0.4.201−0.2.5890.2.773
      DDR1−2.1<.001−1.4.036−0.9.407
      DDT−0.9.002−1.6<.001−0.6.359
      DDX1−0.3.479−0.5.201−0.1.959
      DDX251.2.0011.5.0021.1.125
      DDX39B0.8.0630.9.1041.3.129
      DDX3X−0.2.7050.3.624−0.3.713
      DDX6−0.1.942−0.1.888−0.5.665
      DECR1−0.3.48−0.8.045−0.8.191
      DES−2<.001−2.7<.001−2<.001
      DHAK−0.8.009−1.1.003−0.9.102
      DHRS70.2.8120.8.3370.6.737
      DHX37−1.4.008−0.5.5310.6.677
      DHX90.4.2490.3.5370.5.503
      DIABLO−0.9.008−0.7.126−0.6.418
      DKK3−1.7<.001−2<.001−1.5.021
      DLAT−0.7.011−0.7.028−0.6.308
      DLGAP1−0.6.372−0.7.372−0.1.953
      DLST−0.4.084−0.5.109−0.5.359
      DMD−0.5.103−0.2.649−0.1.998
      DNAH5−0.5.336−1.1.0690.4.75
      DNAH9−2.6<.001−2.005−0.3.881
      DNAJA2−0.5.009−0.7.012−0.5.257
      DNAJB110.4.3260.1.987−0.2.874
      DNAJB4−0.5.062−0.5.147−0.2.829
      DNM1L0.2.6370.1.958−0.1.889
      DNPEP−0.4.301−0.4.437−0.2.893
      DNTTIP1−2.1<.001−1.4.012−0.7.474
      DNTTIP20.4.2660.3.5550.8.231
      DPP30.3.244−0.3.4080.1.989
      DPT−0.1.988−0.8.1140.1.994
      DPYSL2−0.5.027−0.8.008−0.5.345
      DPYSL3−0.9<.001−0.9.002−0.5.264
      DRAP10.1.926−0.4.294−0.1.899
      DSCAM−1.1790.9.3470.7.679
      DSP−0.4.352−1.07−0.6.58
      DST−0.8.151−1.147−0.1.989
      DSTN−1.3<.001−1.2.001−0.7.172
      DTWD2−1.7.003−0.9.237−1.6.195
      DUSP3−1.001−1.003−0.4.458
      DUT−0.8.084−1.1.045−0.9.345
      DYNC1H10.4.2460.7.0720.6.348
      DYNC1I20.1.95−0.1.8550.4.721
      DYNC1LI1−0.7.035−0.6.18−0.7.349
      DYNC1LI2−0.3.432−0.3.585−0.1.954
      DYNLRB1−1.6<.001−2.001−1.5.069
      ECH1−0.2.47−1.3.001−0.4.582
      ECHS1−0.9.001−1.2.001−0.8.115
      ECM1−0.1.842−0.2.7240.1.986
      EEA1−0.4.096−0.6.045−0.5.283
      EEF1A20.4.296−0.5.2880.3.793
      EEF1B2−0.4.195−0.8.04−0.3.771
      EEF1D−0.3.266−0.8.008−0.4.553
      EEF1DP30.1.95−0.2.8151.4.231
      EEF1G0.7.0020.6.0250.6.162
      EEF20.3.2570.2.7160.2.767
      EFEMP1−1.5<.001−0.9.079−0.7.438
      EFEMP2−0.7.012−0.7.062−0.3.721
      EFHD1−1.2.001−1.1.021−0.7.369
      EFHD21.4<.0010.5.2410.8.217
      EFL10.3.576−0.1.9140.6.496
      EGR4−2.2<.001−2.3.002−1.2.315
      EHD10.3.1560.3.3460.3.453
      EHD2−0.9.005−0.5.2510.1.94
      EHD3−0.5.2140.2.7790.3.8
      EHD4−0.8.001−0.7.014−0.4.395
      EIF1−0.2.69−0.6.0540.2.857
      EIF2A−1.5<.001−1.005−1.1.025
      EIF2B1−0.4.3210.4.4310.1.965
      EIF2S1−0.2.604−0.4.208−0.1.971
      EIF2S30.1.8450.2.636−0.1.939
      EIF3A−0.2.7860.4.4210.1.916
      EIF3F−0.3.454−0.9.016−0.6.37
      EIF3I−0.1.812−0.6.18−0.2.893
      EIF4A10.1.9010.1.9590.2.852
      EIF4A2−0.4.128−0.6.062−0.2.756
      EIF4A30.2.583−0.1.9230.3.792
      EIF4B0.1.929−0.2.802−0.1.939
      EIF4G2−0.2.775−0.1.9790.2.891
      EIF4G3−0.1.918−1.9.0010.2.894
      EIF4H−0.3.5660.1.9730.1.987
      EIF50.2.6830.2.7380.6.317
      EIF5A0.2.678−0.3.6780.5.661
      EIF6−0.7.027−1.1.012−0.3.725
      ELANE1.3.0011.4.0041.7.019
      ELAVL1−0.7.058−0.7.147−0.6.553
      ELN−1.7<.0010.2.73−0.8.362
      ELOB−0.4.156−0.5.21−0.1.907
      EMD−0.2.7840.5.3180.6.431
      EMILIN1−1.3<.001−0.3.371−0.5.315
      EMILIN2−0.1.851−0.3.539−0.2.851
      EML2−1.1<.001−1.2<.001−0.6.283
      EML30.3.767−0.1.9480.3.899
      ENAH−0.7.012−0.6.135−0.5.52
      ENAM−1.3.001−1.2.014−0.5.551
      ENDOD1−0.1.86−0.2.656−0.1.976
      ENG0.4.2150.7.0830.5.475
      ENO1−0.5.005−0.4.135−0.2.762
      ENO2−0.7.001−0.5.064−0.3.582
      ENOPH1−0.4.478−0.8.153−0.1.969
      ENPP1−0.2.6080.1.881−0.2.866
      ENPP20.4.1930.1.860.3.77
      EPB41L20.2.6450.3.630.2.899
      EPDR1−0.3.392−0.3.503−0.1.995
      EPHX1−0.1.864−0.8.0080.1.908
      EPPK1−0.8.061−0.9.102−0.8.395
      EPRS10.4.2270.3.4630.2.86
      EPS15L1−0.3.538−0.3.597−0.3.772
      EPS8L1−1.5.003−1.4.035−0.5.699
      ERBIN−0.8.018−0.3.6430.2.821
      ERC2−1.027−2.9<.001−1.9.03
      ERH0.4.2710.2.7020.4.578
      ERI10.8.4540.5.7221.6.412
      ERLIN2−1.001−0.5.17−0.7.256
      ERO1A0.4.4480.2.740.9.311
      ERP29−0.4.121−0.9.004−0.5.364
      ERP440.1.901−0.6.088−0.1.997
      ES1−0.7.016−0.9.016−0.4.606
      ESD−0.8.002−1.002−0.5.432
      ESYT10.7.0270.6.1670.7.291
      ESYT2−0.1.9360.2.8220.5.572
      ETF1−0.2.627−0.5.283−0.2.864
      ETFA−0.7.008−1.5<.001−0.9.068
      ETFB−0.3.281−0.9.007−0.7.231
      EXOC3−1.7.001−1.7.003−0.9.356
      EXT1−1.3.001−0.6.297−0.8.362
      EYS−1.6.0030.4.647−0.5.729
      EZR−0.1.844−0.3.395−0.2.696
      F100.5.241−0.9.1210.4.725
      F11−0.6.144−0.2.8540.2.881
      F12−0.5.121−0.8.045−0.4.602
      F13A11.0010.4.2940.9.137
      F13B0.6.068−0.3.5910.5.44
      F20.7.0030.3.2710.8.05
      F9−0.5.08−0.1.9160.5.458
      FABP1−3.4<.001−3.5<.001−3.2<.001
      FABP3−2.2<.001−2.4<.001−1.4.058
      FABP4−1.7<.001−2.1<.001−1.4.028
      FABP50.2.691−0.9.06−0.1.959
      FAH−1.1<.001−1.5<.001−0.9.023
      FAM135A1.3.0071.1.0861.3.208
      FAM180A−1.4.0170.4.63−0.2.908
      FAM50B0.8.1451.5.0241.9.058
      FANCA1.7.0012.7<.0011.8.043
      FANK10.9.091−0.9.1790.4.777
      FARSB0.2.7310.2.8010.3.772
      FASN0.1.8−0.5.311−0.3.749
      FAU1.7<.0011.061.8.012
      FBLIM1−1.5<.001−1.1.013−0.7.328
      FBLN1−0.4.086−0.5.1470.2.762
      FBLN20.1.92−0.4.3480.1.981
      FBLN5−2.1<.001−0.9.095−0.9.297
      FBN1−0.4.4051.3.0110.8.315
      FCGBP0.2.6160.1.9950.1.928
      FCGR3A0.4.422−0.2.8540.9.299
      FDPS−0.3.369−0.3.415−0.1.907
      FERMT2−1.2<.001−0.7.114−0.4.618
      FERMT31.9<.0011.8<.0011.3.031
      FGA0.9.0071.4.0021.1.12
      FGB1.1.0061.6.0021.2.168
      FGG1.2.0021.6.0021.1.153
      FGL2−1.2.001−1.4.002−0.9.18
      FH−1.005−1.8<.001−1.2.091
      FHL1−1.5<.001−1.044−0.5.65
      FHL2−0.2.719−0.2.670.4.582
      FHL3−0.7.019−0.6.122−0.3.784
      FHL5−0.6.037−0.4.292−0.6.356
      FIGNL1−1.6.002−1.14−1.6.118
      FILIP1L−1.5<.001−1.3<.001−1.6.001
      FIS1−0.4.281−1.1.004−0.4.521
      FKBP1A−0.7.007−0.9.005−0.3.685
      FKBP2−0.6.028−0.9.003−0.6.237
      FKBP3−0.9.007−1.5.002−1.4.027
      FKBP4−0.4.222−0.5.18−0.8.153
      FKBP50.5.293−0.9.093−0.3.773
      FKBP9−0.1.9210.4.5360.6.667
      FLAD1−1.8.005−1.1.187−1.2.378
      FLII0.3.3360.5.2450.7.212
      FLNA−1.3<.001−0.7.084−0.8.165
      FLNB0.2.666−0.4.456−0.3.799
      FLNC−1.7<.001−1.1.002−1.2.009
      FLOT10.1.7740.4.1560.2.792
      FLOT20.7.0221.2.0020.9.118
      FMOD−1.2.001−1.1.013−0.7.35
      FN1−0.4.1420.2.7310.1.959
      FN3K−1.4.013−2.4.001−0.3.837
      FOXL10.1.96−1.0620.2.881
      FRMD60.1.912−0.7.2030.4.72
      FRZB−1.3.001−1.1.038−0.9.325
      FSCN10.4.335−0.1.840.4.668
      FSIP2−1.3.002−1.4.006−0.7.403
      FSTL1−1<.001−0.8.005−0.8.084
      FTH10.4.482−0.3.688−0.3.798
      FUBP1−0.4.279−0.6.181−0.5.602
      FUCA10.6.033−0.5.1350.4.506
      FURIN−2.7<.001−3.1<.001−2.8.012
      G6PD0.2.4620.3.2380.2.773
      GAA−0.3.413−0.7.03−0.1.923
      GALM−1.2<.001−1.8<.001−1.3.013
      GANAB0.1.6620.1.9570.2.806
      GAPDH−0.9<.001−1.001−0.7.157
      GAPDHS−0.7.249−1.165−0.3.821
      GARS10.4.46−0.2.783−0.2.879
      GART−0.5.305−0.5.375−0.1.986
      GAS6−0.3.492−0.9.038−0.2.889
      GASK1B−2.3<.001−1.7.001−1.7.011
      GBA−0.4.515−0.3.647−0.7.493
      GBE1−0.4.2080.3.5110.4.536
      GBLP0.2.621−0.3.506−0.2.827
      GBP1−1.008−1.2.011−0.5.593
      GC0.3.186−0.3.4730.5.357
      GCA1.1.0011.7<.0011.1.091
      GCLC0.7.003−0.4.2340.4.567
      GDI1−0.7.015−0.8.019−0.2.829
      GDI20.1.719−0.2.60.2.773
      GFPT1−0.4.4310.3.631−0.1.968
      GFUS0.3.4780.3.4160.2.773
      GGT50.6.1080.1.9051.1.095
      GJA1−0.7.047−0.2.672−0.2.807
      GLDC−0.1.971−1.3.0170.5.679
      GLIPR2−0.4.219−0.4.3490.2.891
      GLO1−0.9<.001−1.1<.001−0.6.091
      GLOD4−0.4.136−0.9.004−0.2.852
      GLRX−0.2.675−0.9.008−0.3.725
      GLS−0.6.146−0.5.355−0.2.86
      GLUD1−0.6.048−0.7.053−0.8.181
      GM2A0.2.704−1.2.013−0.1.958
      GMFG0.4.416−0.2.7780.1.953
      GNA11−0.6.199−0.3.6870.3.847
      GNA130.1.946−0.7.20.1.941
      GNAI20.3.4130.3.4550.5.422
      GNAI30.5.2170.4.3720.5.522
      GNAQ0.1.8320.4.4240.2.889
      GNB1−0.6.014−0.6.056−0.4.541
      GNB2−0.5.088−0.7.048−0.3.718
      GNB4−0.4.166−0.5.18−0.1.959
      GNG12−0.7.089−0.7.189−0.3.824
      GNPDA10.2.7480.1.8880.3.75
      GNPTAB−0.2.833−0.1.9550.7.458
      GOLM1−0.9.239−1.3.143−0.3.888
      GOT1−1.001−1.3.001−1.1
      GOT2−0.1.946−0.6.110.1.998
      GPBP1L1−4<.001−2.2.011−2.137
      GPC40.2.79−0.5.350.2.907
      GPC6−0.2.704−0.1.8720.3.771
      GPD1L−1.002−1.1.006−0.6.354
      GPI−0.2.536−0.1.7280.2.676
      GPM6A−0.3.5840.6.350.4.725
      GPNMB1.1.031−0.1.9230.3.871
      GPX10.2.611−0.5.1560.3.721
      GPX3−0.4.125−0.4.269−0.1.944
      GPX40.1.893−0.5.358−0.2.91
      GRB2−0.4.124−1.001−0.4.375
      GRB70.1.832−0.3.4280.2.826
      GRHPR−0.4.145−0.6.084−0.2.77
      GRP78−0.5.05−0.3.311−0.6.188
      GSN−0.8<.001−0.8.002−0.6.128
      GSR−0.5.003−0.7.001−0.6.056
      GSS−1.9<.001−3.2<.001−2.3.003
      GSTM2−0.1.966−0.3.5840.4.668
      GSTM30.1.924−0.1.8620.5.352
      GSTO10.3.0310.1.70.3.464
      GSTP1−0.8<.001−0.6.016−0.5.244
      GSTT1−0.4.237−0.5.3340.1.917
      GUK1−0.8.032−0.8.131−0.3.822
      GULP1−0.9.003−0.7.098−0.9.152
      GYG1−0.5.153−0.7.0920.1.986
      H1-0−0.2.52−0.2.6590.1.899
      H1-52<.0011.4.0261.7.067
      H2AC21−0.7.04−1.1.012−0.9.191
      H3−3A0.4.2750.4.421.1.129
      H4−160.7.1510.2.8540.9.348
      HAAO−1.6<.001−1.7<.001−0.8.127
      HABP2−0.3.491−0.5.207−0.1.919
      HADH−0.7.002−1.2<.001−0.9.017
      HADHA−0.3.337−0.5.092−0.2.729
      HADHB−0.3.241−0.4.073−0.3.626
      HAGH−0.7<.001−1<.001−0.7.015
      HAPLN1−1.6<.001−1.2.007−1.1.118
      HAPLN3−1.4.001−0.9.084−0.4.695
      HARS2−1.009−1.035−0.6.533
      HBA10.5.215−1.017−0.5.567
      HBB−0.1.901−1.4.001−0.6.418
      HBD0.1.969−1.1.005−0.5.563
      HBZ1.019−0.8.179−0.2.917
      HDGF−0.3.3080.1.9920.1.903
      HDGFL3−1.2.003−1.8.001−0.8.362
      HDHD2−0.3.309−0.7.041−0.4.596
      HDLBP0.4.290.2.6780.5.544
      HEBP1−0.5.022−1.001−0.4.513
      HEBP2−1.2<.001−1.1.002−0.7.256
      HEXA−1.002−0.9.025−1.5.012
      HEXB0.1.965−0.5.1510.2.872
      HIBADH−0.2.558−0.7.0720.3.771
      HIBCH−0.3.268−0.8.013−0.4.503
      HINT1−0.5.041−1.2.001−0.3.675
      HK10.3.3530.3.3790.3.719
      HKDC11.3.002−0.4.530.7.526
      HLA-DRA0.7.013−0.3.5680.1.896
      HLCS0.3.576−0.3.678−0.4.756
      HMCN1−1.1.003−0.4.505−0.4.667
      HMGB2−0.1.8320.5.0780.1.908
      HMGCS20.7.18−0.1.9060.5.692
      HNRNPA11.5.0011.6.0020.8.362
      HNRNPA2B1−0.2.589−0.2.642−0.2.761
      HNRNPA30.1.9530.1.9230.1.939
      HNRNPAB−0.2.644−0.8.006−0.4.446
      HNRNPC−0.4.345−1.026−0.3.773
      HNRNPD−0.3.377−0.6.122−0.3.73
      HNRNPF0.2.753−0.4.562−0.2.916
      HNRNPH3−0.4.079−0.3.432−0.3.714
      HNRNPK−0.3.162−0.5.047−0.2.767
      HNRNPL−0.7.006−0.8.026−0.8.138
      HNRNPM−0.2.401−0.2.393−0.4.315
      HNRNPR−0.5.036−0.8.008−0.7.167
      HNRNPU0.5.2160.1.8860.7.384
      HNRNPUL20.3.6040.3.6780.5.677
      HP−0.5.368−1.120.7.529
      HP1BP30.9.0120.8.0681.147
      HPR0.3.544−1.1.0210.4.702
      HPRT11.0010.3.4620.6.294
      HPX−1.001−1.8<.001−0.9.068
      HRG−0.5.024−0.2.557−0.1.994
      HSD17B10−0.6.019−1.1.001−0.8.067
      HSD17B120.2.4790.4.220.4.516
      HSD17B3−1.012−1.044−0.4.741
      HSD17B40.8.0110.3.5430.5.544
      HSF11.3.042−1.4.094−0.2.939
      HSP90AA1−0.2.418−0.2.7010.1.899
      HSP90AB1−0.4.210.2.70.2.784
      HSP90B1−0.1.898−0.2.435−0.2.821
      HSPA2−1.3<.001−0.9.041−0.3.719
      HSPA40.2.788−0.5.266−0.1.954
      HSPA4L−0.1.858−0.6.328−0.5.681
      HSPA5−0.2.241−0.4.059−0.4.247
      HSPA8−0.6.001−0.8.001−0.6.056
      HSPA9−0.1.899−0.3.285−0.1.968
      HSPB1−1.6<.001−1.5.001−1.1.068
      HSPB6−1.6<.001−1.9<.001−1.167
      HSPB7−1.6<.001−1.5.002−0.8.329
      HSPB8−1.9<.001−1.3.011−1.3.085
      HSPD1−0.3.178−0.5.017−0.4.248
      HSPE1−0.5.127−1.2.001−0.6.33
      HSPG2−1.4<.001−0.6.173−0.7.275
      HTR3C−0.5.308−1.6.004−0.8.382
      HTRA1−1.4.001−1.4.005−0.9.256
      HV2060.8.2140.1.9711.9.112
      HV2090.6.225−0.6.3541.1.282
      HV3060.3.681−0.9.1881.1.324
      HYOU1−0.2.526−0.4.346−0.6.345
      IAH1−0.7.012−0.7.028−0.3.725
      IARS10.4.1120.3.5390.3.676
      IARS2−0.6.131−0.2.817−0.1.979
      IDH1−0.3.117−0.6.009−0.2.706
      IDH20.8.0020.7.0460.6.345
      IDH3A0.2.621−0.6.139−0.1.998
      IDNK0.7.184−2.003−1.4.199
      IER50.2.783−0.7.1590.4.693
      IFT460.4.325−0.7.1270.7.345
      IGDCC3−4.2<.001−2.4.002−3.6.001
      IGF2−1.001−1.1.003−0.3.735
      IGFALS0.8.0160.1.9870.9.196
      IGFBP2−1.4<.001−1.3.005−1.157
      IGFBP3−0.5.3040.5.420.3.79
      IGFBP5−1.003−0.3.553−0.4.693
      IGFBP6−1.1.002−1.3.003−1.116
      IGFBP7−1.9<.001−0.9.049−0.8.315
      IGHA1−0.2.774−1.1.0090.3.734
      IGHA2−0.3.59−1.3.010.3.777
      IGHD−0.1.909−1.089−0.1.932
      IGHG1−0.2.548−0.7.0510.5.484
      IGHG2−0.8.018−1.4.002−0.1.974
      IGHG3−0.2.666−0.4.383−0.2.888
      IGHG4−0.2.799−0.5.3670.7.455
      IGHM0.3.526−1.0460.6.542
      IGHV2-70D−1.2.046−1.6.035−0.9.499
      IGHV3-20−0.1.988−0.4.4570.4.697
      IGHV3-490.3.527−1.1.0380.7.452
      IGHV3-64D0.2.793−0.7.1180.7.372
      IGHV3-70.2.721−0.8.0880.8.283
      IGHV3-72−0.1.873−0.7.1430.7.417
      IGHV3-740.3.609−1.0410.8.286
      IGHV6-10.8.126−0.3.6751.356
      IGKC−0.2.6−1.0070.3.734
      IGKV1-12−0.2.758−0.5.4991.284
      IGKV1-16−0.3.649−1.4.0090.2.86
      IGKV1-6−0.1.981−0.8.0790.3.782
      IGKV2-240.2.795−1.2.0070.5.582
      IGKV3-20−0.4.266−0.9.0130.3.71
      IGKV3D-150.2.763−1.5.0030.5.607
      IGKV3D-20−0.4.47−1.6.0030.4.746
      IGKV4-1−0.1.998−1.020.6.477
      IGLC7−0.3.586−1.3.0060.4.737
      IGLL1−0.3.435−0.8.0410.3.754
      IGLL5−0.1.874−2.2.0010.5.725
      IGLV1-47−0.1.986−1.4.0050.4.729
      IGLV1-510.1.943−0.6.4561.2.279
      IGLV3-1−0.5.224−1.6.0020.3.809
      IGLV3-12−0.1.819−0.8.0320.6.421
      IGLV3-19−0.5.218−1.3.0070.3.762
      IGLV4-31.1.0620.4.6421.6.153
      IGLV8-61−0.3.636−0.3.620.4.772
      IL12RB1−3.7<.001−1.6.044−2.6.026
      IL1RAPL10.2.863−1.5.0280.8.527
      IL1RL10.3.702−1.2.0560.2.91
      IL34−1.9<.001−1.021−1.7.009
      IL4I10.7.005−0.2.5680.5.335
      ILF2−0.7.121−1.1.039−0.9.294
      ILK−0.8.001−0.2.557−0.3.656
      IMMT−0.5.01−0.4.143−0.5.189
      IMPA1−0.9.007−1.4.001−0.5.571
      IMPDH2−0.6.097−0.3.5530.1.967
      IMPG1−0.8.242−0.4.6420.2.907
      INF2−0.2.819−0.9.282−0.4.792
      INKA10.8.033−0.4.3970.3.801
      IPO50.7.0190.7.1060.6.42
      IPO7−0.1.7850.1.8260.1.906
      IPO9−0.2.531−0.3.539−0.2.88
      IQGAP10.1.7950.1.9260.3.659
      IRGC−0.9.0670.2.779−0.4.761
      ISLR−0.3.574−0.6.311−0.3.793
      ISYNA1−0.7.098−0.6.348−0.1.927
      ITGA1−0.4.3090.2.6880.6.44
      ITGA11−0.6.167−0.3.683−0.2.878
      ITGA3−1.5<.001−0.8.035−0.8.177
      ITGA5−1.002−0.6.203−0.4.611
      ITGA7−2<.001−1.6<.001−1.3.012
      ITGA8−1.7<.001−1.1.009−1.145
      ITGAV−1.1<.001−0.9.003−0.9.047
      ITGB1−0.7.014−0.5.2−0.2.844
      ITGB21.1.0011.1.0040.9.168
      ITGB30.9.0091.6.0010.7.315
      ITGB5−1.001−1.008−0.8.192
      ITIH10.3.486−0.4.3980.4.675
      ITIH20.4.225−0.4.2450.1.923
      ITIH30.7.022−0.1.9150.7.275
      ITIH40.2.69−0.7.0240.4.511
      ITIH5−1.4<.001−1.2.002−0.6.345
      ITM2B−1.1.001−1.021−0.5.488
      ITPR1−0.5.1780.1.8890.2.86
      IVD−0.7.088−0.5.4−0.7.387
      IVNS1ABP−0.5.12−0.3.605−0.3.688
      JCHAIN0.3.38−0.9.0180.3.713
      JMY0.7.2581.4.0692.068
      K132L−1.4.002−1.3.036−0.3.807
      KANK2−1.002−0.6.15−0.4.649
      KANSL3−0.2.802−1.9.001−0.6.52
      KAT6B−0.6.126−0.1.9670.2.878
      KAT8−1.7.002−1.4.047−0.4.825
      KCNF1−1.1.125−2.023−1.1.503
      KCTD12−0.2.538−0.9.017−0.3.725
      KDEL2−0.6.046−0.5.17−0.6.39
      KHSRP−0.3.52−0.3.621−0.4.704
      KIF26B0.3.799−1.6.120.4.878
      KIF2A0.7.2330.7.3531.4.244
      KIF5B−0.3.467−0.2.73−0.3.765
      KLB−0.3.29−0.3.491−0.1.899
      KLC1−0.5.118−0.6.118−0.3.657
      KLF10−0.9.049−0.6.33−0.5.677
      KLKB1−0.1.781−0.7.0490.1.959
      KMT5C−0.3.4450.3.4780.5.355
      KNG1−0.1.903−0.7.010.1.919
      KNTC10.3.733−0.4.6421.1.315
      KPNB10.4.1540.2.7370.5.364
      KREMEN20.6.301−0.6.4280.5.756
      KRT10.1.791−0.4.41−0.4.661
      KRT100.1.953−0.1.876−0.3.768
      KRT181.7<.0011.1.0192.3.001
      KRT19−0.7.02−1.1.0060.3.771
      KRT20.4.37−0.4.5040.2.868
      KRT71.1.0040.7.1551.3.079
      KRT73−1.7<.001−1.7<.001−2.001
      KRT77−0.1.986−0.6.452−0.7.652
      KRT80.1.882−0.5.2890.8.242
      KRT9−0.1.792−0.3.449−0.2.767
      KSR20.9.041−0.5.4331.2.167
      KTN1−0.6.008−0.9.004−0.6.245
      KV204−0.7.04−1.5.001−0.2.793
      KV3030.5.301−1.1.0380.9.299
      KV3040.2.829−1.2.110.4.813
      KV3080.5.359−0.7.2890.6.656
      KV402−0.7.096−1.1.0330.3.78
      KY−1.081−0.4.6490.1.986
      LACTB2−0.3.416−0.8.023−0.8.129
      LAMA2−1.003−0.9.038−0.7.36
      LAMA40.3.368−0.2.7030.8.233
      LAMA5−1.8<.001−0.8.032−0.9.118
      LAMB1−0.2.7560.1.8390.3.729
      LAMB2−1.8<.001−0.8.03−0.9.084
      LAMC1−1.3<.001−0.7.065−0.6.329
      LAMP10.5.0060.1.9030.4.41
      LAMP20.7.0020.4.1680.4.369
      LAMTOR10.2.593−0.1.9840.1.918
      LAMTOR30.7.0090.7.0330.4.496
      LANCL1−0.8.004−0.5.14−0.2.771
      LAP30.2.709−1.002−0.2.754
      LASP1−0.2.766−0.3.5840.3.773
      LBP−0.1.8210.1.8990.6.402
      LBX1−1.2.008−1.7.004−1.1.262
      LCA5L1.1.2122.1.0551.5.422
      LCP11.3<.0010.9.0211.1.056
      LDB3−1.8<.001−1.3.002−1.1.103
      LDHA0.2.6210.2.6570.5.29
      LDHAL6A0.4.410.1.9841.1.16
      LDHB−0.3.128−0.5.024−0.2.729
      LDLR0.1.856−0.6.1870.3.773
      LECT2−0.8.146−0.4.605−0.4.756
      LEFTY2−1.5.001−0.9.107−0.9.326
      LEMD20.3.483−0.1.8810.8.329
      LETM1−0.7.007−0.6.045−0.8.106
      LGALS1−1<.001−0.9.004−0.5.315
      LGALS3−0.5.02−1.2<.001−0.7.147
      LGALS3BP−1.4<.001−1.5.001−1.6.009
      LHPP−1.2.001−1.8<.001−1.2.04
      LIMS1−1.1.001−0.9.009−0.7.24
      LIMS2−1<.001−0.9.004−0.6.283
      LMAN21.4<.0011.3.0011.4.009
      LMCD1−1.6<.001−1.1.013−0.8.237
      LMNA−0.9.005−0.9.018−0.5.498
      LMNB10.8.0231.2.0091.133
      LMNB2−0.5.033−0.4.178−0.1.878
      LMOD1−1.4<.001−0.8.067−0.7.316
      LOXL1−1.7<.001−0.4.405−0.6.412
      LPA1.6<.001−0.5.3761.4.05
      LPCAT2−0.2.401−0.4.174−0.1.947
      LPP−1.5<.001−0.9.034−0.8.259
      LRG1−0.3.305−1.1.0020.1.999
      LRP1−0.2.555−0.2.7150.2.815
      LRP12−2.3<.001−1.1.127−0.4.772
      LRP6−2.001−1.6.036−1.4.252
      LRPAP1−0.8.015−0.9.043−0.4.666
      LRRC47−0.6.063−0.8.049−0.5.496
      LRRC591.7<.0011.1.0130.7.378
      LRRC72−2.7<.001−1.1.141−1.8.127
      LRRC90.5.219−0.3.499−0.3.767
      LSM3−0.3.271−1.1.002−0.3.748
      LSM6−0.4.121−0.5.167−0.5.337
      LSM7−1.8.001−2.4.001−2.048
      LSM8−1.037−1.9.002−1.4.153
      LTA4H0.1.8080.3.4760.2.773
      LTBP1−1.1<.001−0.2.713−0.3.737
      LTBP2−1.1<.001−0.9.01−0.5.493
      LTBP4−2.2<.001−1.1.011−1.1.083
      LTF1.031.4.0121.4.112
      LUM0.3.548−1.1.019−0.1.993
      LV106−0.2.808−0.6.3560.3.79
      LXN1.3.004−0.4.5710.9.332
      LYPLA1−0.3.488−1.2.015−1.2.12
      LYST−0.2.785−1.4.0030.5.618
      LYZ−0.3.363−0.2.7950.3.725
      LZIC−0.3.237−0.9.005−0.3.677
      LZTR10.1.984−0.6.4240.2.9
      MACF1−0.7.031−0.4.378−0.6.362
      MACROH2A10.8.0110.5.2950.9.137
      MAGEE1−2.8<.001−1.1.054−1.7.056
      MAGEH10.4.211−0.2.6510.2.773
      MAMDC2−0.4.374−0.5.332−0.4.718
      MAOA0.1.989−0.3.5680.3.762
      MAOB−0.1.87−0.2.7580.3.773
      MAP1B−1.2<.001−0.9.009−1.032
      MAP4−0.6.044−0.6.112−0.5.407
      MAPK1−0.3.246−0.9.003−0.2.767
      MAPK10−0.6.4480.5.6480.5.771
      MAPRE1−0.4.203−0.6.071−0.3.681
      MARCKS1.2<.0010.7.0670.9.09
      MAST3−0.6.113−0.7.1590.1.923
      MAT2B−0.5.154−0.7.074−0.4.636
      MB−3.2<.001−2.5<.001−2.8.001
      MCAM−0.7.023−0.6.1350.1.953
      MCEMP10.4.627−0.7.474−0.7.714
      MDFIC0.6.173−0.7.190.5.675
      MDH1−0.6.011−1.2.001−0.6.315
      MDH2−0.4.184−1.1.001−0.6.237
      MDM1−1.9<.001−0.7.177−0.7.476
      ME1−0.5.401−1.4.052−0.6.676
      ME20.5.2660.1.9810.6.509
      MECP2−0.4.083−0.4.215−0.3.602
      MEGF6−1.003−0.3.591−0.8.244
      MESD−0.7.033−1.3.003−1.147
      METRNL−0.5.264−0.1.898−0.4.719
      METTL25−0.3.717−1.1450.8.462
      METTL7A0.2.746−0.2.7381.276
      MFAP2−0.9.0230.3.5580.2.883
      MFAP4−2<.001−1.4.016−1.325
      MFAP5−0.6.072−1.2.002−0.6.39
      MFGE8−2.7<.001−1.9.001−1.8.015
      MGP−1.9<.001−1.3.039−0.8.503
      MGST31.2.0041.0721.3.118
      MIF−0.6.019−0.5.133−0.2.814
      MINPP10.5.264−0.9.082−0.7.503
      MLH10.3.519−0.8.104−0.5.589
      MLKL0.3.5310.1.9710.8.334
      MLTK0.4.2750.7.0660.7.317
      MMP2−0.9.011−0.9.032−0.9.212
      MMP91.0291.6.0081.2.209
      MMRN10.8.0231.3.0040.2.829
      MOCS2−1.3<.001−1.2.001−0.7.188
      MOS−0.4.529−0.8.314−0.5.765
      MPDZ0.6.069−0.6.1590.2.82
      MPO1.1.0042.4<.0011.4.054
      MPST−0.6.032−1.5<.001−0.4.561
      MRC20.4.3020.2.7830.3.759
      MRVI1−0.8.02−0.5.232−0.6.387
      MSN−0.7<.001−0.5.022−0.5.195
      MSRB3−1.3.001−2.2<.001−0.9.283
      MST10.2.7840.3.646−0.1.998
      MT−CO20.5.3010.7.1861.2.159
      MTHFD10.1.812−0.2.7310.2.889
      MTPN−0.2.507−0.7.017−0.1.997
      MVP0.1.7260.2.6480.3.589
      MYADM0.3.5741.5.0041.244
      MYCBP20.1.986−0.8.380.7.675
      MYDGF−0.2.636−0.8.121−0.5.59
      MYH10−1.1.001−0.4.41−0.3.767
      MYH11−1.5<.001−0.5.299−0.4.699
      MYH13−0.5.294−0.3.6880.1.923
      MYH14−0.6.162−0.1.9460.2.903
      MYH2−0.4.455−0.1.980.3.771
      MYH90.3.3590.6.060.4.503
      MYL6−1.3<.001−0.8.027−0.5.477
      MYL6B−1.2.001−0.5.381−0.2.891
      MYL9−1.4<.001−1.2.002−0.8.195
      MYLK−1.1<.001−0.9.006−0.6.276
      MYO18A−2.1<.001−2.7.001−2.3.026
      MYO1C−0.4.2260.1.8550.3.725
      MYO1D0.3.5560.4.3650.6.472
      MYO5B−0.6.3520.2.889−0.4.792
      MYOF0.2.7810.4.3970.3.725
      MYOM20.2.737−0.9.0660.3.773
      MYOM3−1.2.001−1.3.007−0.5.614
      NAA15−1.3.202−3.3.0060.2.94
      NAGK0.3.29−0.2.4730.3.578
      NAMPT0.6.0691.3.0021.129
      NAP1L10.2.792−0.3.6390.1.976
      NAP1L4−0.8.001−0.9.001−0.6.149
      NAPA−0.2.691−0.6.14−0.4.545
      NAPG−0.2.608−0.2.8130.1.944
      NAPRT−0.4.412−0.6.2480.1.923
      NARS1−0.2.722−0.2.799−0.3.771
      NASP0.2.7171.1.0190.7.421
      NAV1−1.7.001−0.5.41−1.3.127
      NAV20.5.413−0.7.2630.4.771
      NAXE−0.6.148−0.7.1970.3.788
      NCKAP1−0.3.550.3.5250.2.871
      NCL−0.3.389−0.5.1910.1.994
      NCOA10.4.476−0.1.914−0.8.466
      NDRG1−0.6.04−0.6.079−0.4.536
      NDRG3−0.9.001−1.1.001−0.8.12
      NDUFA10−0.5.176−1.2.006−0.2.887
      NDUFA13−0.5.165−0.5.212−0.3.721
      NDUFA40.5.1620.4.3950.7.402
      NDUFA5−0.3.411−0.5.165−0.8.165
      NDUFA60.2.417−0.1.7320.1.994
      NDUFB11−0.3.46−0.4.479−0.2.817
      NDUFB40.3.5480.2.7990.5.582
      NDUFS10.3.437−0.4.3830.1.968
      NDUFS3−0.1.926−0.6.3950.1.94
      NDUFS8−0.1.964−0.5.067−0.2.72
      NDUFV2−0.4.145−0.8.012−0.4.602
      NECAP20.8.1621.1471.1.33
      NEDD8−1.2.002−1.9.001−0.3.773
      NEGR1−1.002−0.8.053−0.4.598
      NENF−1.3.002−1.2.028−0.7.469
      NEXN−1.001−1.005−0.8.165
      NHSL10.2.853−0.8.367−0.1.998
      NIBAN−0.5.046−0.1.7880.1.978
      NIBL11.0080.4.5191.239
      NID1−0.9.001−1.002−0.5.329
      NID2−0.2.604−0.5.1710.4.666
      NIT2−0.7.002−1.001−0.5.335
      NKX1−2−0.3.615−1.1.07−0.5.685
      NLRC4−1.4.001−1.2.022−0.7.461
      NLTP0.5.024−0.1.9030.1.999
      NME10.4.414−0.5.3970.1.964
      NNMT0.3.5230.1.8810.4.677
      NOLC12.0012.5.0011.6.129
      NOTCH3−1.003−0.4.431−0.4.668
      NPC20.2.727−0.3.5870.1.94
      NPEPPS−0.3.428−0.6.0840.2.805
      NPM10.3.1470.1.8360.3.664
      NPNT−1.9<.001−0.6.245−0.8.323
      NPTN−0.7.009−0.5.174−0.3.729
      NQO2−1.001−1.1.004−0.6.364
      NRAP−0.5.162−0.4.3760.4.699
      NSF0.6.0460.4.2950.2.821
      NSFL1C0.1.899−0.5.2330.11.00
      NSMCE30.5.103−0.4.3830.8.242
      NT5E−0.2.7860.1.8550.2.889
      NUCB1−0.1.971−0.4.186−0.2.753
      NUCB2−0.4.193−0.7.041−0.4.606
      NUCKS1−0.2.806−0.9.1910.7.549
      NUDC−0.5.063−0.4.3260.1.998
      NUDT2−0.3.351−0.3.4520.1.992
      NUDT50.1.817−0.7.0520.4.582
      NUTF2−0.7.001−0.8.002−0.6.146
      OAF−2.2.001−2.021−1.9.153
      OAT0.2.6150.2.6720.2.829
      OBSCN−1.7.01−0.6.5290.4.829
      OGDH0.3.460.1.8620.2.84
      OGN−0.9.022−1.2.016−0.4.731
      OLA1−0.5.013−0.6.007−0.4.379
      OLFM10.7.146−0.2.7651.1.217
      OLFML10.3.377−0.2.6740.2.889
      OLFML30.3.623−0.2.8110.6.535
      OMD0.7.1150.2.8260.6.587
      OPTN0.2.75−0.3.5970.1.91
      OR10T2−0.7.1350.3.6820.4.762
      OR4C3−2.2<.001−1.8.002−2.1.012
      OR51Q1−2.6<.001−2.5.003−0.9.582
      OR56B4−0.5.382−0.3.7810.1.961
      ORM1−0.4.291−0.9.012−0.1.995
      ORM20.1.877−0.9.0050.4.59
      OSTF10.6.014−0.1.960.2.781
      OTUB1−0.1.891−0.3.5430.3.725
      OVOS2−0.4.382−1.4.002−0.9.252
      OXCT1−1<.001−1.2.001−1.1.012
      OXSR10.3.2690.5.1330.2.881
      P4HB0.1.954−0.1.801−0.1.837
      PA2G40.4.2960.2.7530.4.66
      PACSIN2−1<.001−1.004−0.5.36
      PAFAH1B10.1.949−0.1.8860.1.842
      PAFAH1B2−0.2.553−0.9.002−0.3.696
      PAFAH1B31.2.0010.1.8750.6.464
      PAICS−0.3.3290.1.959−0.1.907
      PALLD−1.2<.001−1.1.001−0.8.092
      PARK7−0.9<.001−1.2<.001−0.8.02
      PARVA−1.6<.001−1.2.002−0.7.24
      PAWR−0.5.131−0.4.375−0.2.827
      PBXIP1−2.2<.001−1.083−1.4.091
      PCBD1−0.6.21−0.7.234−0.2.881
      PCBP1−0.3.067−0.3.137−0.3.378
      PCBP2−0.4.22−0.6.06−0.7.212
      PCDHB140.5.2380.3.6480.8.253
      PCMT1−0.5.017−1.001−0.5.237
      PCOLCE−0.1.709−0.4.175−0.3.59
      PCOLCE2−1.005−0.9.053−1.1.129
      PCYOX1−0.5.035−0.8.013−0.3.703
      PCYT2−0.6.104−0.6.171−1.146
      PDAP1−0.8.106−0.3.654−0.4.772
      PDCD10−0.1.892−0.3.512−0.6.387
      PDCD5−0.8.003−1.1.002−0.9.071
      PDCD6−1.002−0.7.066−0.5.521
      PDCD6IP−0.6.005−0.4.203−0.6.153
      PDCD7−1.1.03−1.1.073−0.1.99
      PDGFC−2.3<.001−1.8.004−1.7.067
      PDHA1−0.3.57−0.9.039−0.9.217
      PDHB−1.3.002−1.3.009−1.6.032
      PDIA2−1.9<.001−1.2.036−2.2.009
      PDIA3−0.4.031−0.5.019−0.4.214
      PDIA4−0.4.171−0.8.009−0.5.329
      PDIA50.8.0030.6.060.3.656
      PDIA60.2.615−0.4.15−0.1.918
      PDLIM1−1.3<.001−1.3<.001−0.9.043
      PDLIM2−0.6.091−0.5.3690.1.976
      PDLIM3−1.6<.001−1.3.002−0.8.249
      PDLIM4−1.2.001−0.9.043−0.5.537
      PDLIM5−0.8.027−0.8.055−0.5.549
      PDLIM7−1.6<.001−1.3.011−0.7.376
      PDS5A0.6.0180.3.3921.05
      PDXK0.5.064−0.2.7230.6.191
      PEA15−1.1<.001−1.2.001−0.8.138
      PEBP1−1.2<.001−1.5<.001−0.8.129
      PEF1−1.1.001−0.6.174−1.3.032
      PEPD−0.5.009−1.2<.001−0.4.356
      PF40.6.2860.8.2320.4.767
      PFDN1−0.9.007−1.012−0.6.362
      PFDN2−1.3<.001−1.7<.001−1.2.065
      PFDN5−0.5.012−0.9.002−0.5.283
      PFKL1.0011.2.0021.1.03
      PFKM−1.002−0.5.29−0.3.756
      PFKP−0.5.1960.4.4240.1.908
      PFN1−0.4.012−0.5.045−0.4.332
      PFN2−1.3<.001−0.9.003−1.031
      PGAM1−0.6.029−0.6.085−0.2.851
      PGD1.0010.8.0410.9.144
      PGK1−0.4.075−0.4.203−0.2.773
      PGK2−0.8.021−1.1.022−0.4.713
      PGLS−0.4.043−1.001−0.4.455
      PGLYRP2−0.1.757−0.7.045−0.1.939
      PGM1−0.6.001−0.5.014−0.4.275
      PGM20.1.858−0.5.1710.2.89
      PGM30.5.1150.1.8890.4.619
      PGM5−1.7<.001−1.2.006−0.7.315
      PGP−1.1.004−0.8.0950.1.953
      PGRMC1−1.3<.001−1.006−0.7.219
      PHB−0.1.706−0.5.093−0.2.815
      PHB20.3.387−0.2.5750.3.647
      PHGDH−1.2<.001−1.2.002−0.6.379
      PHPT1−0.8.001−0.9.005−0.6.237
      PI4KA−1.012−1.1.021−0.2.907
      PIK3C3−0.5.201−0.6.288−0.1.94
      PIMREG0.3.562−0.4.4870.9.253
      PITHD1−0.4.156−0.7.018−0.3.635
      PITPNB−0.2.738−0.1.90.4.719
      PITRM1−1.4.001−1.059−0.6.531
      PKD2−1.2.001−0.5.32−0.4.675
      PKM0.1.858−0.1.9280.3.647
      PKP4−2.1.028−0.5.765−1.3.582
      PLA2G2A−1.006−0.5.389−0.2.907
      PLAUR0.5.4790.3.80.1.988
      PLCD1−1.6<.001−1.3.004−1.14
      PLCH10.2.6990.1.8920.3.734
      PLD30.4.302−0.3.6150.4.71
      PLEC0.7.0070.4.350.5.422
      PLG0.8.0090.6.1450.6.356
      PLIN1−0.5.141−0.7.11−0.1.959
      PLIN3−0.4.233−0.9.011−0.3.729
      PLOD10.4.3820.5.3740.2.83
      PLP2−0.1.8740.3.7110.7.563
      PLS3−0.6.063−0.6.153−0.1.909
      PLTP0.8.026−0.2.8470.4.722
      PLXDC2−0.3.469−0.9.0130.1.998
      PLXNB20.2.7880.2.7540.2.849
      PNP0.7.0210.2.7160.3.677
      PODN−0.3.301−1.2.001−0.6.245
      POLD1−1.6.026−0.8.447−2.1.147
      PON10.9.008−0.3.6050.7.413
      POSTN0.6.221−0.2.8110.1.995
      POTEF−0.7.081−1.6.002−0.4.725
      POTEI−1.4.001−1.7.001−0.7.421
      POTEJ−0.8.021−1.3.003−0.4.63
      PPA1−0.7.008−1.2.001−0.6.369
      PPA20.1.874−0.3.389−0.3.725
      PPBP−0.8.035−0.9.048−1.147
      PPCS−0.2.732−0.5.171−0.2.817
      PPFIBP1−0.3.335−0.8.03−0.7.275
      PPIA−0.5.028−0.6.032−0.3.637
      PPIB0.2.4380.1.9060.2.773
      PPIC−0.3.531−0.3.479−0.5.474
      PPM1F−2<.001−1.6.002−2.1.005
      PPME10.8.080.3.6270.5.686
      PPP1CB−1.4<.001−0.9.034−0.7.315
      PPP1CC−0.7.296−0.4.699−0.6.719
      PPP1R12A−0.7.001−0.7.006−0.7.118
      PPP1R12B−1.7<.001−1.4.003−0.7.327
      PPP1R14A−1.8<.001−1.4.004−0.7.364
      PPP1R7−0.8.016−0.9.045−1.1.102
      PPP2R1A−0.1.7020.1.8840.2.772
      PPP6R3−1.181−1.4.138−0.5.808
      PPT1−0.2.576−0.8.034−0.4.541
      PRAF20.2.707−0.1.9240.3.772
      PRDBP−0.3.60.5.4620.8.436
      PRDX1−0.7.001−1.001−0.6.138
      PRDX20.3.222−0.5.097−0.1.929
      PRDX30.1.988−0.4.06−0.2.63
      PRDX40.4.4050.4.473−0.1.998
      PRDX5−0.2.537−0.5.043−0.2.668
      PRDX6−0.5.006−0.6.004−0.3.46
      PRELP0.1.836−0.7.0610.2.821
      PRKACA−0.6.019−0.6.067−0.3.751
      PRKACB−1.012−0.5.3970.1.955
      PRKAR1A−1<.001−1.2<.001−0.9.034
      PRKAR2A−1.2<.001−1.1.01−0.7.327
      PRKCB−2.5.003−2.4.023−1.669
      PRKCSH0.1.966−0.4.179−0.1.969
      PRKG1−1.002−0.4.418−0.2.891
      PROC0.4.154−0.6.0670.2.851
      PROS10.6.033−0.3.4030.8.158
      PROSC−1.026−1.2.025−1.252
      PROX2−1.1.003−0.7.138−0.5.618
      PRPF4B−0.8.034−0.8.085−1.171
      PRPS10.1.877−0.1.862−0.2.827
      PRR36−0.6.224−0.6.352−0.3.792
      PRSS23−0.6.188−0.6.286−0.7.378
      PRTG0.8.033−0.8.1220.2.878
      PRTN31.3.0022.0011.5.05
      PRXL2A0.1.96−0.6.1670.7.281
      PSAP−0.6.018−0.6.055−0.2.734
      PSIP1−1<.001−1.4<.001−1.1.021
      PSMA1−0.1.965−0.7.0450.1.98
      PSMA2−0.2.575−0.6.039−0.3.691
      PSMA30.2.454−0.2.5680.1.998
      PSMA40.2.526−0.5.0860.1.889
      PSMA5−0.3.35−0.9.002−0.3.594
      PSMA60.1.909−0.6.0110.1.889
      PSMA7−0.2.534−0.3.4240.3.771
      PSMB10.4.2630.1.8840.5.393
      PSMB20.3.45−0.3.5760.3.696
      PSMB30.4.241−0.6.1220.3.677
      PSMB4−0.4.223−0.8.014−0.2.815
      PSMB5−0.3.314−0.9.013−0.3.721
      PSMB6−0.6.004−1.001−0.6.149
      PSMB70.8.2020.5.5430.9.514
      PSMB81.1.0050.9.0661.9.008
      PSMB90.9.0020.2.6520.8.149
      PSMC10.2.544−0.2.7160.1.963
      PSMC20.3.4480.3.4870.3.676
      PSMC30.5.113−0.2.6150.4.676
      PSMC40.1.766−0.2.7290.2.776
      PSMC5−0.3.221−0.4.237−0.2.849
      PSMC60.4.2140.3.546−0.1.998
      PSMD10.3.3190.1.8170.4.582
      PSMD110.2.439−0.2.6470.3.679
      PSMD120.1.999−0.2.7810.2.868
      PSMD130.5.1010.1.9150.5.424
      PSMD14−0.2.548−0.8.004−0.3.608
      PSMD20.6.0320.5.2190.5.46
      PSMD30.4.2170.3.4380.5.475
      PSMD5−0.4.182−0.3.5940.1.9
      PSMD60.9<.0010.7.0330.9.048
      PSMD70.1.889−0.3.5370.3.8
      PSMD9−0.3.326−0.8.0180.2.767
      PSME10.2.322−0.3.3450.2.777
      PSME20.3.313−0.4.202−0.1.923
      PSMF1−1.001−1.008−0.6.342
      PTBP1−0.3.341−0.8.013−0.4.541
      PTGES3−0.7.024−0.8.021−0.3.678
      PTGIS0.3.3651.1.0041.2.04
      PTGR1−1.4.001−0.9.067−1.3.091
      PTK2−0.5.068−0.7.052−0.1.939
      PTMA−0.1.923−0.2.7540.2.829
      PTMS−0.8.007−1.007−0.4.631
      PTPA0.1.879−0.5.1050.1.908
      PTPN11−0.8.004−0.6.09−0.6.315
      PTPN13−1.8<.001−1.044−1.6.026
      PTPN4−1.8<.001−0.7.201−0.9.315
      PTRF−1.3<.001−1.017−0.9.144
      PURA−0.8.007−0.6.11−0.3.675
      PUS10−0.1.967−0.5.6060.7.696
      PXDN−0.1.874−0.2.6970.3.736
      PYGB−0.6.066−0.6.132−0.1.903
      PYGL0.4.2450.8.0190.6.345
      PZP−0.6.2040.2.847−0.3.788
      QARS10.5.1060.1.915−0.1.956
      QDPR−0.9.001−1.3<.001−0.7.191
      QSOX1−0.6.051−0.6.158−0.3.725
      QTRT1−0.6.1−1.2.009−0.3.754
      RAB100.6.0120.7.0260.7.129
      RAB11B−2.001−1.206−1.2.329
      RAB14−0.1.875−0.3.41−0.2.775
      RAB181.1.020.8.1830.8.469
      RAB21−0.1.845−0.4.244−0.1.953
      RAB23−1.4<.001−1.012−0.5.472
      RAB2A−0.1.8−0.5.2420.2.807
      RAB350.3.3920.3.4950.4.582
      RAB410.3.512−0.7.1040.8.275
      RAB5B−0.9.005−1.2.004−0.2.802
      RAB5C−0.4.524−1.7.0180.1.976
      RAB7A0.3.301−0.3.4020.2.772
      RAC1−0.3.473−0.7.1790.2.905
      RAC30.5.3540.6.3740.7.6
      RACK10.3.1140.2.6280.3.554
      RAD18−2.4<.001−1.5.025−2.1.032
      RAD23A−0.1.844−0.4.5750.4.687
      RAD23B−0.3.296−0.8.008−0.4.369
      RALY−0.2.61−0.2.6180.3.714
      RAN0.1.996−0.1.892−0.1.949
      RANBP1−0.2.509−0.6.0480.1.968
      RAP1A−0.4.4880.1.888−0.2.907
      RAP1GDS1−1.008−0.8.077−0.8.318
      RARRES2−0.7.066−0.4.402−0.3.771
      RBBP8NL−0.9.081−0.5.519−0.1.982
      RBCK10.4.27−0.5.3120.7.326
      RBMX−0.7.019−0.9.01−0.6.308
      RBP1−1.2<.001−0.8.032−0.4.609
      RBP4−0.6.034−1.7<.001−0.9.115
      RBPMS−1.3<.001−1.3.001−0.8.203
      RBX10.5.327−1.2.043−0.4.719
      RCN1−0.5.171−0.8.038−0.2.81
      RCN30.6.0260.5.1510.5.408
      RDX−0.9.045−0.4.549−1.286
      RECQL0.8.0090.7.0870.8.191
      REEP50.1.875−0.7.177−0.2.912
      REEP6−0.3.483−0.5.330.1.957
      RFTN10.1.953−0.3.5140.3.773
      RGS22−0.1.893−1.0360.4.685
      RHBDF1−0.9.049−0.6.293−0.1.967
      RHOA0.7.0220.9.0320.8.244
      RHOB−1.6<.001−1.3.001−1.3.01
      RHOC−1.009−1.041−0.6.513
      RHOG0.6.0970.9.0240.7.278
      RIC8A0.2.6920.5.1210.2.792
      RIF1−0.5.155−0.6.184−0.2.829
      RILPL1−1.5<.001−1.6<.001−1.2.009
      RINT10.2.827−0.4.7240.9.578
      RNASE1−1.3.003−1.9.001−1.8.021
      RNASE4−0.6.141−0.2.781−0.2.828
      RNF31−0.4.544−1.171−0.3.876
      RNH1−0.3.131−0.2.518−0.1.983
      RNPEP−0.2.611−0.4.421−0.4.656
      RPL100.1.9660.2.8730.1.988
      RPL10A0.6.0670.6.1410.7.252
      RPL110.2.783−0.2.6690.3.792
      RPL120.2.5220.3.3930.3.675
      RPL130.7.0240.5.2370.9.167
      RPL140.4.225−0.1.960.3.7
      RPL151.1.0021.2.0051.2.077
      RPL171.2.0010.7.171.148
      RPL181.0030.7.0891.2.066
      RPL18A0.8.0221.1.0110.9.234
      RPL22−0.1.858−0.2.7470.3.725
      RPL23−0.1.937−0.4.372−0.2.832
      RPL23A−0.4.152−0.8.012−0.5.418
      RPL241.1.0060.9.110.6.511
      RPL271.6<.0011.3.0081.9.008
      RPL27A0.6.0410.4.3350.6.321
      RPL281.0010.8.0331.058
      RPL291.0010.6.1320.8.157
      RPL31.1.0011.0131.2.045
      RPL30−0.1.816−0.5.3740.5.646
      RPL310.3.578−0.4.5370.3.762
      RPL340.8.0620.7.1790.4.719
      RPL351.1.0350.6.4111.7.083
      RPL381.4.0071.1680.7.575
      RPL41.0040.7.0831.151
      RPL50.7.0480.4.3520.9.199
      RPL61.1<.0010.9.0061.2.009
      RPL70.8.0021.0051.048
      RPL7A0.8.010.6.1070.8.212
      RPL80.5.306−0.3.6880.2.869
      RPL90.6.1510.3.6720.6.501
      RPLP0−0.4.444−0.6.324−0.1.953
      RPLP1−0.6.089−0.9.038−0.5.582
      RPLP2−0.5.114−0.7.067−0.3.771
      RPN10.4.1180.2.650.3.725
      RPN20.8.0030.8.0240.7.19
      RPS101.1.0030.7.1591.2.06
      RPS110.5.1080.3.4760.6.355
      RPS120.1.615−0.1.737−0.1.889
      RPS131.0020.5.2941.129
      RPS140.4.3490.3.5510.8.242
      RPS15A0.6.0480.7.0880.8.242
      RPS160.8.0220.7.161.1.103
      RPS180.9<.0010.9.0021.015
      RPS190.2.515−0.2.6670.4.554
      RPS20.7.0320.6.1290.7.262
      RPS20−0.1.961−0.3.5580.1.939
      RPS21−0.3.532−0.9.028−0.2.907
      RPS230.6.1441.0440.7.369
      RPS240.4.4550.6.2430.9.26
      RPS250.6.1120.2.6720.6.461
      RPS27L−2.4<.001−1.7.01−0.6.687
      RPS28−1.2.0740.2.885−0.9.575
      RPS30.5.0450.2.7650.5.422
      RPS3A0.7.020.5.1450.7.214
      RPS4X1.2.0011.2.0051.2.071
      RPS50.5.0880.3.4310.5.469
      RPS60.9<.0011.1.0010.8.071
      RPS6KA21.0570.2.8251.3.246
      RPS6KA3−2.001−2.2.004−0.4.83
      RPS70.6.0770.5.320.9.195
      RPS80.2.430.3.3390.3.677
      RPS91.0011.2.0021.2.019
      RPSA0.2.546−0.6.099−0.1.961
      RRAD−0.3.662−0.1.9160.6.648
      RRAS−1.002−0.6.143−0.4.701
      RRBP10.2.614−0.4.418−0.6.355
      RSAD2−0.6.3630.7.4150.4.797
      RSU1−1.1<.001−1.2.002−0.8.182
      RTCB−0.8.002−0.7.045−0.5.41
      RTN40.1.8870.2.747−0.1.986
      RTRAF−0.4.072−0.8.007−0.3.591
      RUNDC3A0.8.08−0.2.740.7.514
      RUVBL1−0.3.368−0.3.398−0.2.771
      RUVBL2−0.2.705−0.5.168−0.2.826
      S100A11−0.2.457−0.4.186−0.3.675
      S100A130.4.227−0.1.9480.3.748
      S100A160.3.2790.1.9160.4.533
      S100A4−0.9.001−0.7.027−0.6.309
      S100A6−0.4.111−0.7.019−0.2.741
      S100A81.3.0041.7.0031.7.047
      SAA10.6.380.7.3522.4.021
      SAMHD11.0020.4.3611.09
      SAMM500.7.1830.9.1511.8.05
      SARS1−0.2.558−0.4.3250.1.879
      SBDS−0.8.009−1.01−0.2.792
      SBSPON−2.2<.001−1.9<.001−1.7.003
      SCARB21.2.0071.4.0121.7.05
      SCN8A−0.8.125−0.7.259−0.3.864
      SCRN1−0.9.002−1.007−0.3.725
      SCUBE3−1.7<.001−0.8.052−1.109
      SCYL20.3.785−1.3121.1.533
      SDHA−0.5.133−0.8.05−0.4.656
      SDHB−0.2.7660.1.9150.2.899
      SEC11B−0.1.806−0.7.107−0.1.939
      SEC13−0.1.949−0.5.362−0.2.86
      SEC14L5−0.2.746−0.4.5520.5.649
      SEC22B0.9.0071.020.7.339
      SEC23A0.2.79−0.2.71−0.2.876
      SEC31A0.7.0210.6.1210.4.691
      SELENBP1−0.7<.001−1<.001−0.5.182
      SELENOM−1.5<.001−1.2.006−1.3.034
      SELENOP0.1.901−0.3.5640.2.79
      SEMA3B−1.3<.001−0.7.109−0.6.422
      SEMA5B−0.2.8−1.2.0660.8.533
      SERBP1−0.5.118−0.4.256−0.5.376
      SERPINA1−0.3.29−1.4<.001−0.3.687
      SERPINA100.2.83−0.8.149−0.1.994
      SERPINA3−0.3.526−0.9.0380.3.773
      SERPINA4−0.1.908−0.3.3760.1.94
      SERPINA5−1.001−0.9.027−0.5.445
      SERPINA6−0.2.758−1.009−0.2.849
      SERPINA7−0.2.64−1.4.001−0.4.554
      SERPINB10.4.1670.5.1480.5.369
      SERPINB60.3.4370.3.5620.7.345
      SERPINC1−0.2.651−0.4.1610.1.916
      SERPIND10.3.263−0.4.1930.5.369
      SERPINE20.9.0580.3.7160.7.488
      SERPINF1−0.1.783−0.8.008−0.3.602
      SERPINF20.5.1170.8.0390.7.294
      SERPING10.1.947−0.8.0450.3.687
      SERPINH10.2.776−0.1.9770.2.829
      SETD1B0.7.0310.1.9231.2.074
      SF3B60.3.656−1.4.0280.1.958
      SFPQ0.1.767−0.3.583−0.5.513
      SFRP1−1.5<.001−1.3.002−1.2.051
      SFXN30.1.845−0.1.8470.4.542
      SGCD−0.6.040.3.4380.4.633
      SH3BGRL−1.1<.001−1.6<.001−0.8.095
      SH3BGRL3−0.1.786−0.6.043−0.2.782
      SH3BP5−0.7.007−0.5.125−0.4.582
      SH3GLB1−0.8.004−0.9.005−0.6.249
      SH3GLB2−0.9.004−1.4.001−0.8.203
      SH3RF21.4<.0012.2<.0011.7.008
      SHMT1−0.5.067−0.6.092−0.4.568
      SIN3B−0.3.494−1.1.036−0.2.9
      SKP1−0.3.359−0.5.138−0.2.829
      SLC22A170.4.575−1.1.140.9.498
      SLC25A10.4.2910.4.3510.6.33
      SLC25A111.2<.0010.9.011.1.046
      SLC25A120.4.2540.6.1220.2.829
      SLC25A240.2.6340.3.5150.3.769
      SLC25A31.2.0011.2.011.2.084
      SLC25A4−0.7.0840.2.7490.4.677
      SLC25A51.0520.6.4341.364
      SLC27A20.2.684−0.5.1530.1.923
      SLC27A3−0.2.769−0.2.69−0.1.94
      SLC2A11.3<.0011.2.0021.2.044
      SLC2A12−0.4.233−0.7.1380.6.393
      SLC30A101.3.040.4.7311.7.206
      SLC3A21.0010.6.1380.5.458
      SLC4A11.8<.0010.8.1260.9.219
      SLC7A6−0.7.112−0.1.885−0.2.862
      SLC9A3R1−0.1.893−1.0740.2.896
      SLC9A50.1.909−0.7.2970.8.476
      SLC9A8−0.9.0460.6.2940.6.634
      SLMAP−1.7<.001−1.1.004−1.081
      SLPI−1.8<.001−0.3.606−0.8.364
      SLX4−1.8.002−1.7.016−0.8.511
      SMARCA5−0.3.445−0.4.340.3.729
      SMOC2−0.9.004−0.8.074−0.8.243
      SMTN−1.9<.001−1.4.001−1.1.068
      SNCA0.5.114−0.7.090.2.899
      SNCG−0.1.8730.4.5121.259
      SND10.5.0840.6.1080.2.791
      SNRNP2000.3.704−0.2.8120.9.458
      SNRPD10.1.912−0.4.4840.3.756
      SNRPD2−0.6.055−0.9.018−0.8.147
      SNRPD30.2.787−0.6.1530.1.993
      SNTB2−0.7.007−0.6.073−0.3.697
      SNX1−0.2.487−0.5.14−0.6.359
      SNX12−1.4<.001−1.1.007−0.9.167
      SNX18−0.6.099−0.1.829−0.2.879
      SNX2−0.4.177−0.9.016−0.7.275
      SNX290.2.812−0.1.8670.6.493
      SNX3−0.6<.001−0.5.009−0.5.085
      SNX6−0.1.846−0.5.120.2.777
      SNX90.2.7330.2.7681.218
      SOD1−0.9<.001−0.9<.001−0.7.032
      SOD20.3.218−0.3.2630.3.582
      SOD3−2.4<.001−1.7.001−1.4.04
      SOGA10.5.431−0.1.9240.5.703
      SON−1.8<.001−1.7<.001−1.6.009
      SORBS1−1.2.001−0.6.182−0.4.675
      SORBS2−1.1.002−0.7.165−0.1.929
      SORBS3−0.6.057−0.2.6440.1.986
      SORD−1.8<.001−1.6.003−1.248
      SOST−2.1<.001−1.085−1.3.145
      SOX6−0.1.864−0.8.0110.1.889
      SPARC−0.3.341−0.8.039−0.7.283
      SPARCL1−2<.001−2.4<.001−1.5.001
      SPCS20.5.326−0.5.418−1.5.115
      SPCS31.3.0011.0331.177
      SPON1−1.4<.001−1.5.001−1.7.004
      SPR−1.1.002−1.1.014−0.4.647
      SPTA11.4<.0010.9.0440.8.237
      SPTAN10.2.705−0.3.4320.3.704
      SPTB1.4<.0010.7.1380.7.378
      SPTBN10.2.593−0.1.8480.3.667
      SQOR0.3.484−0.5.2520.1.916
      SQRD0.7.1770.7.2660.5.692
      SREBF2−1.4.026−1.2−1.473
      SRFBP10.3.549−0.3.7021.24
      SRGAP3−1.6.001−1.7.007−1.8.048
      SRI−0.5.005−0.5.012−0.4.315
      SRM0.1.949−0.6.104−0.2.797
      SRP9−0.6.036−0.8.024−0.4.634
      SRPX−1.040.2.832−0.4.781
      SRRT−1.2.001−0.3.512−0.9.233
      SRSF1−0.3.538−0.4.4240.2.894
      SRSF3−0.2.4990.1.9150.1.949
      SRSF7−0.4.3050.2.80.2.86
      SSB−0.2.482−0.5.0870.3.721
      SSBP1−1.4.001−0.7.212−1.7.031
      SSR10.5.0740.1.96−0.1.993
      SSR40.9.0710.6.3750.8.452
      SSTR2−1.3.09−1.6.078−0.1.974
      ST3GAL6−1.7<.001−0.6.356−0.3.781
      STAB10.5.2860.3.5830.9.289
      STAMBP1.5.1511.2.3610.8.77
      STAT10.6.2780.1.9280.7.58
      STAT60.3.4020.5.1190.5.379
      STIP1−0.2.42−0.6.0410.1.997
      STK25−1.7.005−1.6.043−1.1.419
      STK311.1.0220.1.8850.4.773
      STN1−0.2.783−1.5.0020.4.692
      STOM0.1.8460.2.787−0.1.94
      STT3A1.2.0011.3.0061.3.058
      STX7−0.4.115−0.6.09−0.3.725
      STXBP30.4.1320.1.8220.4.416
      SUCLA2−0.2.477−0.7.014−0.3.719
      SUCLG1−0.9.128−1.3.073−0.7.606
      SUCLG2−0.2.687−0.5.196−0.1.916
      SULF10.4.1790.7.0730.4.589
      SUMF2−0.9.02−0.7.156−0.3.773
      SUN2−0.1.8920.6.1430.7.329
      SUSD2−0.2.7860.3.6210.4.702
      SUSD5−1.8<.001−1.1.02−1.1.118
      SVIL−0.5.118−0.3.436−0.5.444
      SYG0.8.030.6.2710.5.582
      SYHC−0.2.746−0.4.393−0.1.936
      SYNCRIP−0.7.04−1.02−0.9.182
      SYNE1−0.4.229−0.3.60.2.883
      SYNM−1.4<.001−1.3<.001−1.3.008
      SYNPO−0.5.101−0.2.626−0.4.649
      SYNPO2−1.3<.001−0.9.013−0.8.147
      SYPL10.4.450.5.4560.9.318
      TAGLN−2.1<.001−1.6.002−0.9.29
      TAGLN2−0.6.029−0.7.056−0.3.729
      TALDO10.3.103−0.1.9460.1.771
      TARDBP−0.4.221−0.8.014−0.3.703
      TARS10.6.0970.3.5560.2.825
      TARS2−1.2.029−1.4.057−0.6.719
      TASOR2−0.6.099−0.1.969−0.2.889
      TAX1BP3−1.3.008−1.4.028−0.6.631
      TBC1D5−1.3.003−0.3.662−0.2.914
      TBCA−1.3<.001−1.4<.001−0.8.116
      TBCB−1<.001−1.2.001−0.5.369
      TCP10.2.594−0.2.7310.3.677
      TENT2−3.2<.001−3.5<.001−3.3<.001
      TES−1.4<.001−0.9.01−0.8.104
      TF−0.6.048−1.3.001−0.4.589
      TFEB−1.2.152−1.3.189−0.3.889
      TFG−0.3.452−0.6.194−0.3.729
      TGFB10.3.5750.9.0560.2.907
      TGFB1I1−1.7<.001−1.1.007−0.8.2
      TGFBI0.5.1330.4.3350.7.252
      TGM2−0.1.8250.3.6060.7.264
      TH−1.5.001−0.6.312−0.4.767
      THBS12.7<.0011.6.0021.5.047
      THBS21.4.0021.1.0521.262
      THOP1−0.1.879−0.7.1660.4.663
      THSD1−1.9<.001−1.1.001−1.3.007
      THSD4−1.3<.001−0.6.029−1.1.008
      THTPA0.4.666−0.3.803−1.3.364
      THY11.3.0010.4.5130.8.333
      TIMP10.8.065−0.1.9950.1.994
      TIMP2−0.5.241−0.7.171−0.2.914
      TIMP30.7.139−0.2.87−0.3.789
      TINAGL1−2.4<.001−1.5.002−1.3.048
      TJP2−0.2.718−0.1.887−0.4.679
      TKT−0.1.673−0.3.0780.2.667
      TLE7−0.6.006−0.8.003−0.4.526
      TLN1−0.6.005−0.3.311−0.5.317
      TLN2−0.8.01−0.3.499−0.5.513
      TMC30.8.3120.2.8480.6.732
      TMCC20.3.659−1.1.052−0.4.721
      TMED70.4.2890.3.4430.7.275
      TMEM109−0.3.413−0.4.2460.2.767
      TMEM1980.6.141−0.2.7990.9.283
      TMEM214−0.6.157−0.1.90.2.893
      TMEM331.1541.9.0191.5.267
      TMEM43−0.2.58−0.3.6050.1.994
      TMEM67−0.3.6210.1.9661.366
      TMOD1−1.001−1.008−0.3.677
      TMSB4X−1.2.001−1.5.001−1.2.075
      TNC1.0220.5.3951.2.202
      TNFRSF11B−0.5.155−0.9.033−0.5.474
      TNFSF13−1.008−0.6.208−0.6.521
      TNN0.1.817−1.0290.3.792
      TNPO10.2.5560.1.8470.3.677
      TNPO20.5.464−0.6.4080.1.989
      TNRC6C0.5.286−1.1.0270.8.362
      TNS1−1.4<.001−0.6.179−0.6.379
      TNS2−0.1.8120.2.65−0.1.986
      TNXB−1.1<.001−1.2.001−0.4.541
      TOLLIP−1.8<.001−1.3.006−1.7.013
      TOM10.1.837−0.2.7690.3.675
      TOM1L2−0.7.028−0.7.089−1.1.046
      TOR1AIP10.5.0761.0030.7.163
      TPD52L2−0.5.129−1.013−0.5.472
      TPI1−0.3.34−0.4.2490.2.756
      TPM1−2.4<.001−2.2<.001−1.5.028
      TPM2−3.1<.001−2.6<.001−1.9.028
      TPM30.9<.0010.3.3030.5.242
      TPM4−0.3.22−0.4.1−0.2.713
      TPP10.2.684−0.6.151−0.5.488
      TPP2−0.1.875−0.3.680.6.521
      TPT1−1.4.001−1.6.005−1.2.198
      TRIM38−2.1.001−1.3.078−0.5.762
      TRIOBP−0.3.4840.3.426−0.2.813
      TRIP6−1.002−0.8.07−1.1.085
      TSG101−0.4.266−0.8.059−0.4.668
      TSN0.1.89−0.2.6770.1.967
      TTN0.1.999−0.5.1270.1.976
      TTR−0.6.013−1.3<.001−0.6.203
      TTYH2−0.7.007−0.2.632−0.1.916
      TUBA4A−0.3.139−0.4.127−0.4.321
      TUBB−0.3.511−0.8.049−0.3.748
      TUBB1−0.2.830.5.65−0.2.947
      TUBB2A−0.5.144−0.9.017−0.5.452
      TUBB4A−0.1.989−0.2.888−0.5.756
      TUBB4B−0.5.177−1.1.007−0.3.773
      TUBB6−0.7.021−1.009−0.6.344
      TUFM0.3.2780.1.8330.2.714
      TUT7−0.9.029−0.7.234−0.3.775
      TWF1−0.4.176−0.7.056−0.1.951
      TWF2−0.4.431−0.4.524−0.6.532
      TXN−0.5.065−0.7.055−0.3.725
      TXNDC12−0.7.155−0.8.16−1.7.048
      TXNDC17−0.8.001−1.2<.001−0.5.29
      TXNDC5−0.2.66−0.8.016−0.4.538
      TXNL1−0.5.008−0.8.001−0.3.45
      TXNRD1−0.1.873−0.3.3960.4.637
      TYMP1.0020.3.5050.5.511
      TYRP1−0.3.509−0.5.3630.2.88
      U2AF2−0.3.411−0.6.155−0.8.275
      UAP1−0.7.059−0.3.695−0.2.907
      UBA1−0.2.307−0.3.255−0.1.998
      UBAP2L−0.4.192−0.5.101−0.6.305
      UBE2I0.2.7170.6.2080.6.39
      UBE2K−0.6.046−1.3.001−0.9.114
      UBE2L3−0.4.192−0.4.251−0.4.546
      UBE2M−0.8.063−0.9.079−0.7.482
      UBE2N−1.2.001−1.03−0.8.29
      UBE2O−1.3.001−0.4.4560.2.894
      UBE2V10.7.0230.5.2020.6.329
      UBL5−0.4.2−0.5.1840.3.725
      UBR4−1.2.051−0.1.973−0.4.826
      UCHL1−1.001−1.3.002−0.7.329
      UFC1−0.6.007−0.8.004−0.3.614
      UFL10.2.757−0.3.630.2.88
      UFM1−0.3.338−1.1.002−0.3.751
      UGDH−0.3.451−0.3.625−0.1.964
      UGGT10.5.1710.5.2410.1.923
      UGP2−0.7<.001−0.6.006−0.4.276
      UNC45A0.3.569−0.1.8840.4.677
      UQCR101.6<.0011.3.0021.1.058
      UQCRC1−0.6.113−0.8.072−0.9.229
      UQCRC2−0.9.006−0.8.039−1.1.068
      UQCRH−0.4.34−0.6.209−0.3.767
      USO1−0.2.697−0.7.0920.4.667
      USP140.2.624−0.3.5240.3.765
      USP15−0.8.064−0.2.7280.3.835
      USP17L13−0.2.585−0.6.045−0.2.777
      USP17L18−0.1.795−0.2.7160.1.894
      USP17L19−1.2.003−1.1.033−0.3.781
      USP17L20−0.2.569−0.7.049−0.4.52
      USP17L22−0.4.175−0.7.069−0.5.475
      USP5−0.1.898−0.2.7−0.1.959
      UTP14A−1.9<.001−2.1.001−1.3.188
      UTRO0.5.0790.5.1540.8.149
      VAPA−0.7.138−0.8.165−0.8.44
      VASP−0.7.001−0.4.142−0.7.075
      VAT1−0.3.32−0.6.054−0.3.711
      VCAN−1.9<.001−1.034−1.3.085
      VCL−1<.001−0.6.053−0.5.364
      VCP−0.1.881−0.3.296−0.2.719
      VDAC1−0.1.873−0.4.104−0.4.36
      VDAC2−0.3.283−0.9.012−0.6.345
      VDAC30.5.3720.6.3350.3.799
      VILL0.1.819−1.1.0110.4.676
      VIM−1.6<.001−1.5<.001−1.2.012
      VIRMA−0.4.3090.3.5640.6.407
      VPS11−0.1.774−0.1.9730.1.978
      VPS29−0.7.028−0.7.071−0.7.333
      VPS350.2.684−0.1.8510.5.468
      VPS4B−0.6.22−0.6.279−0.6.536
      VTN−0.6.063−0.9.024−0.6.321
      VWA1−1.5<.001−1.7<.001−1.3.034
      VWA3A0.2.7340.5.2330.2.829
      VWA3B−0.1.953−0.9.1310.2.899
      WASHC1−0.5.624−0.3.847−0.7.773
      WASHC4−2.5<.001−0.6.465−0.4.829
      WBP11−0.8.1130.6.4240.4.792
      WDR1−0.5.005−0.3.166−0.1.865
      WDR76−0.3.29−0.9.006−0.2.86
      WDR82−0.4.504−0.1.9280.1.968
      WDR83OS−2.1<.001−1.074−1.1.222
      WISP2−1.003−0.5.2540.2.879
      WRAP73−0.8.132−0.8.1910.5.714
      WTIP−0.8.14−0.7.295−0.1.941
      XDH−3.2<.001−2.6<.001−2.7<.001
      XPO10.5.1270.6.120.7.329
      XRCC50.8.0110.7.1030.9.137
      XRCC60.2.6120.2.6770.6.32
      XRN1−1.4.004−1.3.044−0.4.773
      YAP1−0.8.002−1.004−0.6.283
      YKT6−0.4.301−0.4.3960.2.889
      YPEL10.2.8060.2.8391.2.271
      YWHAB−0.3.164−0.3.167−0.1.913
      YWHAE−0.3.279−0.6.038−0.2.703
      YWHAG−0.6.002−0.7.003−0.3.59
      YWHAH−0.4.097−0.6.02−0.3.582
      YWHAQ−0.3.301−0.3.4240.1.903
      YWHAZ−0.3.225−0.4.135−0.2.681
      ZBTB21−0.9.015−0.1.942−0.1.956
      ZC2HC1C−0.7.1030.5.4410.1.955
      ZMYND8−1.5<.001−0.9.067−1.152
      ZNF3501.1.062−0.6.456−0.5.746
      ZNF385A0.5.441.7.0141.7.115
      ZNF4790.1.8710.2.630.4.438
      ZNF507−0.6.091−1.1.014−0.3.773
      ZNF597−0.5.232−0.5.3980.3.773
      ZSCAN9−0.8.432−0.4.753−0.2.944
      ZSWIM90.1.864−0.7.0480.4.656
      ZYX−1.001−0.8.013−0.8.132
      Log2FC, Log2 fold change; TAA, thoracic aorta aneurysm; TADA, thoracic aorta dissection and aneurysm; TBAD, type B dissecting aorta.
      a False discovery rate.
      Supplementary Table IIIComplete differential expression analysis between aortic pathologies
      GeneLog2FC TAA/TADAAdjusted P valueLog2FC TBAD/TADAAdjusted P valueLog2FC TAA/TBADAdjusted P value
      A1BG−0.1.984−0.8.3240.7.068
      A2M−0.3.966−1.1.3630.8.191
      AAMDC−0.8.857−0.6.708−0.2.825
      AARS10.1.982−0.2.8990.3.684
      ABCA13−1.862−0.5.822−0.5.591
      ABCCB−0.8.9−0.7.821−0.2.943
      ABCD1−0.6.929−1.6850.5.729
      ABCF1−0.3.982−1.7.2351.5.066
      ABHD14B−0.4.941−0.9.5150.5.441
      ABI3BP−0.5.9−0.2.936−0.4.659
      ACAA10.6.90.1.9940.6.506
      ACAA20.5.941−0.1.9730.5.561
      ACADM0.5.90.2.9330.4.676
      ACADVL0.4.903−0.5.7820.8.108
      ACAN−0.6.9030.5.822−1.195
      ACAT1−0.2.972−0.6.7130.4.59
      ACAT2−0.1.982−0.6.7130.6.407
      ACLY0.4.9410.2.9330.2.865
      ACO1−0.3.941−0.4.8150.1.924
      ACO20.3.966−0.3.8530.5.409
      ACOT9−0.4.941−0.5.7970.2.899
      ACP1−0.3.946−1.3230.7.179
      ACSF2−1.3.857−0.9.759−0.5.732
      ACSL10.6.9270.5.8440.1.961
      ACTA1−0.6.9−0.5.762−0.1.975
      ACTBL2−0.8.857−0.2.942−0.7.176
      ACTN1−0.6.862−0.1.942−0.5.307
      ACTN2−0.5.9−0.5.6770.1.962
      ACTN30.4.969−0.3.9330.7.593
      ACTN4−0.7.857−0.5.792−0.3.693
      ACTR10−0.4.9−0.4.7920.11.00
      ACTR1A−0.1.982−0.6.6520.6.337
      ACTR2−0.1.9820.2.891−0.2.634
      ACTR3−0.1.982−0.1.997−0.1.922
      ACYP2−0.2.982−0.4.8910.2.894
      ADAM17−0.8.862−0.6.762−0.2.844
      ADAMTS20.5.957−1.4.5531.9.066
      ADAMTSL1−0.6.90.4.847−1.133
      ADAMTSL2−0.9.9030.3.942−1.2.383
      ADAMTSL4−0.6.9−0.1.985−0.5.526
      ADARB1−0.8.862−1.1.3280.3.733
      ADD10.5.927−0.3.9080.8.35
      ADD30.1.982−0.1.9730.2.846
      ADGRF11.1.857−0.6.7921.6.023
      ADH1B−0.7.903−0.6.822−0.2.945
      ADH5−0.4.9−0.6.6930.2.84
      ADIPOQ−1.2.857−1.574−0.3.819
      ADIRF−0.7.9−0.5.847−0.3.855
      ADSL0.3.9270.1.980.3.688
      ADSS1−1.1.8570.1.989−1.1.124
      AEBP1−0.1.982−0.2.9510.1.966
      AFM−0.2.972−1.2.2251.065
      AGL−0.4.934−0.5.8150.1.962
      AGRN−0.3.969−0.4.820.2.862
      AGT−0.2.972−1.3240.8.133
      AHCY0.1.982−0.4.7920.5.413
      AHCYL10.1.993−0.4.7960.4.512
      AHNAK0.1.9820.2.934−0.1.943
      AHSG0.1.982−1.1.2251.1.023
      AIFM10.4.9−0.1.9850.4.429
      AIMP2−0.1.982−0.2.9330.1.943
      AIP−0.4.927−0.2.917−0.2.84
      AK1−0.1.982−0.2.9170.1.943
      AK20.3.969−0.7.7620.9.203
      AK30.5.90.2.9420.4.613
      AK4−0.5.9030.1.993−0.5.529
      AK70.9.9−0.3.9171.2.179
      AKAP12−0.1.982−0.5.7920.5.557
      AKR1A1−0.3.941−0.9.3910.6.29
      AKR1B10.1.982−0.6.4680.7.094
      AKR7A20.5.903−0.3.8610.7.264
      AKR7A30.3.982−0.3.9530.5.785
      ALAD0.1.982−0.6.7620.7.334
      ALB−0.2.982−1.2.2861.1.071
      ALCAM−0.6.9−0.1.993−0.5.459
      ALDH1A1−0.3.903−0.5.6420.2.75
      ALDH1B1−0.6.9−0.3.899−0.3.688
      ALDH1L1−0.3.966−0.4.8220.2.902
      ALDH2−0.3.947−0.6.7620.3.757
      ALDH6A1−0.5.903−0.6.7890.2.927
      ALDH7A1−0.4.9−0.6.6740.2.811
      ALDH9A1−0.3.941−0.7.6150.4.561
      ALDOA−0.2.941−0.2.8260.1.988
      ALDOC−0.5.862−0.3.815−0.2.688
      ALMS10.2.982−0.4.8190.6.403
      ALOX15B−0.1.982−0.3.8990.2.862
      AMBP−0.2.982−0.6.7420.5.544
      AMIGO20.1.993−0.5.8260.5.652
      AMN−0.3.982−0.3.9330.1.982
      AMPD20.2.9820.3.897−0.2.902
      ANG−0.4.941−0.4.847−0.1.998
      ANGPTL2−0.3.969−0.2.946−0.2.916
      ANK10.9.8570.1.9880.9.178
      ANKRD31−1.3.862−1.782−0.4.84
      ANKS3−1.2.9−0.6.891−0.7.714
      ANP32B−0.6.927−0.8.7850.3.889
      ANTXR10.1.9820.8.657−0.7.363
      ANXA1−0.2.9470.1.985−0.3.663
      ANXA11−0.2.9570.2.861−0.4.399
      ANXA2−0.2.982−0.2.8910.1.945
      ANXA3−0.5.912−0.2.938−0.3.757
      ANXA4−0.3.941−0.11.00−0.3.691
      ANXA5−0.3.957−0.3.8340.1.962
      ANXA6−0.3.941−0.1.997−0.3.705
      ANXA70.1.9820.2.897−0.1.873
      AOC3−1.2.857−0.1.993−1.1.122
      AP1B10.6.8620.1.9420.5.383
      AP2A1−0.2.972−0.3.8950.1.97
      AP2A20.2.982−0.2.9560.4.774
      AP2B10.2.982−0.3.8650.4.529
      AP2M1−0.2.982−0.4.8430.2.829
      AP3B10.2.972−0.3.8470.5.429
      AP3B2−0.9.9−0.5.853−0.4.753
      AP3S1−0.3.969−0.2.935−0.2.932
      APCS−0.7.9−0.9.6140.3.85
      APEH0.5.903−0.2.9530.6.435
      APEX1−0.5.9−0.1.973−0.5.552
      APMAP0.2.9720.1.9560.1.913
      APOA1−0.1.982−1.1.2861.061
      APOA20.1.982−1.2881.1.035
      APOA40.1.982−0.4.8020.5.394
      APOB0.2.982−1.6.2251.7.022
      APOC10.2.982−0.7.7690.8.301
      APOC2−0.2.982−1.7.2251.6.043
      APOC3−0.2.982−1.8.2251.6.023
      APOD0.3.969−1.1.3271.3.025
      APOE−0.1.984−1.4321.116
      APOF0.2.982−0.3.8470.5.503
      APOH−0.2.969−0.4.7920.2.769
      APOL1−0.1.992−1.5.2581.5.037
      APOM0.3.947−0.7.5921.071
      APP−0.1.9970.2.936−0.2.87
      APPL10.2.9810.1.9420.1.966
      APRT0.1.982−0.8.4330.9.068
      AQP1−0.5.9−0.6.7180.2.912
      ARCN10.4.9030.1.9890.4.572
      ARF40.1.982−0.4.8150.5.521
      ARF5−0.2.9750.5.792−0.7.306
      ARFIP1−0.3.941−0.4.7920.2.894
      ARG1−0.3.9740.6.792−0.8.308
      ARHGAP1−0.4.9−0.5.6480.1.899
      ARHGAP11A−0.2.982−0.6.8260.5.768
      ARHGAP31−1.3.862−1.4.5830.2.933
      ARHGAP40−0.3.965−0.5.7920.3.825
      ARHGAP9−1.3.9−1.3.732−0.1.989
      ARHGDIA−0.4.9−0.5.5830.2.862
      ARHGDIB0.4.90.3.8260.2.811
      ARHGEF37−1.3.862−0.6.826−0.7.613
      ARL6IP5−0.2.9810.2.917−0.3.613
      ARL8B−0.8.927−0.2.976−0.6.691
      ARMC50.6.9720.2.9730.4.868
      ARNTL2−0.1.984−0.7.8210.6.657
      ARPC1A−0.4.903−0.4.821−0.1.964
      ARPC1B0.1.9820.1.9510.11.00
      ARPC2−0.1.988−0.1.995−0.1.991
      ARPC30.1.982−0.1.980.2.855
      ARPC4−0.1.982−0.3.7920.3.526
      ARPC50.11.00−0.8.5550.8.182
      ARPC5L−0.5.927−0.9.6680.4.704
      ASAH10.2.982−0.6.6160.7.134
      ASNA−0.1.982−0.6.6740.5.391
      ASPH0.3.9820.1.990.2.889
      ASPN0.2.982−1.3.4511.4.072
      ASS1−0.6.9−0.5.792−0.1.951
      ATAD2B−0.6.941−0.9.7590.4.795
      ATIC−0.2.974−0.4.7920.3.741
      ATL3−0.4.9270.1.956−0.5.506
      ATOX1−0.2.982−0.6.7180.5.483
      ATP1A1−0.2.9820.1.993−0.2.889
      ATP2A2−0.3.9760.3.899−0.6.561
      ATP2B4−0.1.9840.3.906−0.4.761
      ATP5F1A0.1.982−0.2.8970.2.647
      ATP5F1B0.2.982−0.5.770.6.286
      ATP5F1C0.2.982−0.5.7210.6.198
      ATP5F1D0.1.982−0.4.8080.4.438
      ATP5ME−0.7.862−0.6.789−0.2.858
      ATP5MF0.2.9820.2.9730.1.968
      ATP5MG−0.4.957−0.6.8080.2.863
      ATP5PB−0.3.969−0.7.6740.5.556
      ATP5PD−0.1.982−0.3.8260.2.797
      ATP5PF−0.1.982−0.7.6790.6.383
      ATP5PO0.2.974−0.4.7850.6.261
      ATP6V1A0.2.982−0.6.7070.7.191
      ATP6V1B20.2.982−0.5.7820.7.286
      ATP6V1E10.3.941−0.5.7460.8.128
      ATP6V1H0.3.927−0.2.9170.5.401
      ATP8A10.1.984−0.6.8970.6.729
      ATR−1.857−0.4.821−0.6.388
      AXIN1−1.2.903−1.3.7920.2.968
      AZGP1−0.2.974−1.1.3240.9.129
      B2M0.2.982−0.7.4910.8.069
      BAG2−0.6.90.2.939−0.8.301
      BANF1−0.6.903−1.5330.5.581
      BASP1−0.1.9820.1.951−0.2.757
      BBS9−0.3.966−0.1.989−0.2.8
      BCAM−0.8.862−0.2.953−0.7.306
      BCAP31−0.4.966−0.8.7850.4.757
      BCL10−0.2.9820.5.819−0.6.409
      BDH2−0.4.969−0.4.8990.1.998
      BGN−0.5.927−0.5.826−0.1.995
      BLM−0.3.982−0.9.8020.6.72
      BLMH0.7.90.1.9890.7.529
      BLVRA0.1.982−0.2.9330.3.703
      BLVRB0.2.982−0.7.5080.9.071
      BNC2−0.4.946−0.4.8260.1.968
      BPGM0.5.92−0.6.8081.1.172
      BPNT10.1.982−0.3.9280.3.795
      BRK1−0.1.982−0.3.9220.2.894
      BSG−1.2.864−0.1.985−1.1.353
      C11orf54−0.2.982−0.4.8260.2.825
      C11orf96−1.1.862−0.4.88−0.8.444
      C1orf198−0.1.982−0.3.8610.3.8
      C1QA−0.9.9−0.2.951−0.7.491
      C1QB−0.3.9720.1.973−0.4.715
      C1QC−0.5.941−0.3.907−0.2.918
      C1R0.1.99−0.1.9520.2.893
      C1S−0.1.982−0.4.770.3.576
      C2−0.9.862−1.5380.2.911
      C22orf23−0.7.9−0.4.906−0.4.729
      C2orf780.2.9821.2.524−1.1.247
      C3−0.2.972−0.8.4010.7.198
      C4A−0.4.903−0.7.6740.3.757
      C4B−0.1.99−0.5.8080.4.567
      C4BPA−0.1.988−0.8.5240.8.179
      C4BPB0.2.982−1.2.4311.3.061
      C5−0.2.979−0.6.6790.4.506
      C6−0.3.927−0.3.848−0.1.962
      C7−0.3.969−0.1.966−0.2.863
      C8A−0.5.862−0.3.814−0.2.757
      C8B−0.4.903−0.5.7590.2.883
      C8G−0.4.941−0.8.5920.5.558
      C8orf74−0.1.9930.9.753−0.9.372
      C9−0.3.942−0.2.934−0.2.863
      CA10.6.9−0.9.4971.5.022
      CA1230.2.9821.3.639−1.1.36
      CA20.6.9−0.6.7421.2.04
      CA30.3.982−0.4.8910.6.537
      CAB390.2.9820.1.9970.2.912
      CACNA2D1−0.5.903−0.2.942−0.4.703
      CACYBP0.1.9820.1.9730.1.998
      CALD1−0.5.903−0.3.891−0.2.84
      CALR−0.1.982−0.1.9340.1.97
      CALU0.3.9030.1.9730.3.638
      CAMK2G−0.4.9290.6.726−1.103
      CAND1−0.4.903−0.4.822−0.1.962
      CANX0.1.9920.2.928−0.1.863
      CAP10.1.982−0.2.9060.2.753
      CAP2−0.5.9−0.2.917−0.3.719
      CAPG0.5.9−0.3.8650.7.195
      CAPN1−0.1.984−0.2.8940.2.811
      CAPN2−0.5.862−0.4.792−0.2.762
      CAPNS1−0.2.974−0.3.8160.2.812
      CAPZA10.5.9−0.1.9730.6.286
      CAPZA2−0.1.982−0.5.6820.4.441
      CAPZB−0.1.9820.1.951−0.2.742
      CARD101.8780.2.9730.9.399
      CASKIN2−0.3.966−0.4.8470.1.957
      CASP8−0.6.9−0.1.954−0.5.506
      CAST0.3.934−0.3.8390.6.287
      CAT0.4.903−0.2.9060.6.315
      CATSPERG−1.1.862−0.9.773−0.3.863
      CAV1−0.8.9−0.1.993−0.7.413
      CAV2−0.7.878−0.2.917−0.5.523
      CAVIN1−0.8.862−0.6.785−0.3.827
      CAVIN20.7.8620.4.8260.4.633
      CAVIN3−0.9.862−0.3.886−0.6.457
      CBLN2−0.5.9−0.7.6040.3.758
      CBR1−0.4.927−0.6.650.3.684
      CBR3−0.3.982−0.1.989−0.3.873
      CCAR1−0.4.957−1.8.2251.5.07
      CCDC158−0.8.9−0.5.826−0.3.843
      CCDC194−0.9.90.1.981−0.9.296
      CCDC252.9.8621.4.8211.6.544
      CCDC6−0.9.857−0.6.721−0.4.633
      CCDC69−0.5.9570.2.973−0.6.669
      CCDC800.2.982−0.1.9850.3.797
      CCN3−0.5.903−0.5.826−0.1.962
      CCS0.6.903−0.1.990.6.504
      CCT20.1.982−0.2.8360.3.493
      CCT3−0.1.982−0.4.7920.3.664
      CCT40.1.9820.1.962−0.1.979
      CCT50.2.982−0.2.9370.3.688
      CCT6A0.1.9920.1.928−0.1.862
      CCT70.1.982−0.2.9330.2.715
      CCT80.1.982−0.2.9110.3.685
      CD109−0.5.9−0.6.7920.1.979
      CD140.2.982−0.2.9510.4.761
      CD151−0.5.9290.1.993−0.5.613
      CD1630.3.9580.1.9530.2.862
      CD34−0.7.862−0.6.762−0.2.87
      CD44−0.3.927−0.1.992−0.2.666
      CD47−0.2.982−0.1.951−0.1.968
      CD59−0.5.903−0.2.934−0.3.722
      CD5L−0.1.982−1.1.3271.078
      CD81−0.4.942−0.4.8470.1.998
      CD9−0.5.927−0.3.899−0.2.879
      CD970.1.992−0.3.9070.3.793
      CD99−0.1.982−1.5190.9.191
      CDC25C0.4.966−0.6.8260.9.363
      CDC37−0.2.9650.2.932−0.4.539
      CDC42−0.1.982−0.1.99−0.1.945
      CDC5L−0.4.927−1.5.2251.1.065
      CDH1−0.3.982−0.1.993−0.3.863
      CDH13−1.2.857−0.6.792−0.7.383
      CDHR3−0.2.982−1.1.5920.9.343
      CDK5RAP30.3.9740.1.9850.2.87
      CDKN2AIP−0.5.972−1.1.7570.7.657
      CELSR3−0.2.9821.792−1.1.391
      CENPE−1.2.862−0.6.826−0.7.585
      CES1−0.9.8570.1.994−0.9.164
      CFB−0.6.9−0.9.4570.4.654
      CFD−0.3.947−0.9.4570.7.328
      CFH−0.3.927−0.8.3270.6.254
      CFHR1−0.8.9−0.9.6680.2.925
      CFHR2−0.5.9−0.7.6160.2.798
      CFHR5−0.8.878−0.9.590.2.913
      CFI−0.4.903−1.3.2250.9.106
      CFL1−0.1.982−0.2.8260.2.815
      CFL2−1.857−0.7.753−0.4.705
      CFP−0.4.9410.1.976−0.4.581
      CHCHD3−0.5.9270.1.98−0.6.526
      CHD80.2.966−0.1.9820.2.699
      CHMP2A0.2.9820.6.718−0.5.463
      CHMP4B−0.3.966−0.2.928−0.1.945
      CHST14−0.7.90.3.899−1.247
      CHTF18−0.8.941−1.8.4971.1.441
      CILP2−1.7.857−1.5.418−0.3.862
      CIRBP0.3.966−0.4.8480.7.401
      CISD10.1.982−0.2.9570.2.873
      CKAP2−0.2.982−0.8.4570.6.22
      CKAP40.3.969−0.1.9980.3.767
      CKB−0.4.927−0.7.7060.3.757
      CKM0.5.90.5.7920.1.996
      CLEC11A0.6.90.1.9970.6.513
      CLEC3B−0.1.984−0.5.7920.4.526
      CLIC10.3.912−0.1.9340.3.401
      CLIC4−0.5.9−0.6.7420.2.901
      CLTA0.6.90.5.7920.2.916
      CLTB−0.3.972−0.4.8310.2.903
      CLTC−0.1.982−0.2.9350.1.93
      CLU−0.3.972−0.5.7920.3.764
      CMA10.1.982−0.4.8210.5.487
      CMBL−0.5.903−0.5.7920.1.979
      CMPK1−0.4.903−0.6.5240.3.585
      CMYA50.1.982−1.1.5081.2.123
      CN166−0.1.982−0.5.890.4.811
      CNBP0.2.9820.1.9930.2.93
      CNDP2−0.3.947−0.8.5240.5.413
      CNN1−1.2.857−0.5.848−0.8.457
      CNN2−0.1.982−0.1.9370.1.989
      CNN3−0.4.947−0.5.8210.2.933
      CNPY20.3.957−0.4.8260.6.346
      CNRIP1−0.1.982−0.3.7920.3.592
      CNTN1−0.4.903−0.3.892−0.2.84
      COASY0.1.982−0.6.7920.7.416
      COG5−0.4.9030.3.819−0.6.161
      COL12A10.4.946−0.3.8990.7.429
      COL14A1−0.6.903−0.2.942−0.4.691
      COL15A1−0.1.992−0.3.8990.2.812
      COL18A1−0.7.9−0.2.956−0.5.528
      COL1A1−1.9−0.1.988−1.375
      COL1A2−1.9−0.11.00−1.338
      COL21A1−1.8.8570.5.877−2.2.022
      COL3A1−1.3.8620.2.966−1.4.179
      COL4A1−1.1.8570.2.951−1.2.083
      COL4A2−1.3.8570.2.935−1.5.05
      COL4A3−1.8620.3.899−1.3.071
      COL6A1−0.3.9660.2.933−0.5.561
      COL6A2−0.4.9410.3.906−0.6.419
      COL6A3−0.3.947−0.6.7570.3.739
      COL7A10.4.947−0.9.7061.2.115
      COL8A1−1.3.8570.3.936−1.6.08
      COLGALT1−0.3.957−0.3.8530.1.975
      COMT−0.2.982−0.2.947−0.11.00
      COPA0.2.9820.2.934−0.1.968
      COPB10.5.9030.3.8990.2.84
      COPB20.1.982−0.4.8660.4.63
      COPG10.4.9290.3.8990.2.902
      COPS50.3.9410.1.9980.3.691
      COPS6−0.5.918−0.2.933−0.3.779
      CORO1A0.3.9630.3.8990.1.979
      CORO1B−0.2.969−0.5.7620.3.705
      CORO1C−0.4.903−0.4.815−0.1.995
      COTL10.2.969−0.2.8960.4.496
      COX4I10.3.982−0.1.9850.3.814
      COX5A0.2.982−0.5.780.6.312
      COX5B0.6.9−0.3.890.8.164
      COX6B1−0.5.903−0.8.6680.4.743
      COX6C0.6.9410.8.792−0.2.905
      COX7A20.5.9−0.2.9330.7.334
      CP−0.4.903−0.8.4570.5.452
      CPA30.8.9−0.1.9850.9.38
      CPB20.2.969−0.2.9320.4.572
      CPNE1−0.3.9570.2.904−0.4.463
      CPNE3−0.2.9820.5.792−0.7.343
      CPPED1−0.4.93−0.7.6820.4.72
      CPQ−0.3.941−0.4.8180.1.951
      CPXM2−0.6.9−0.4.853−0.3.862
      CREG1−0.5.941−0.6.8220.1.968
      CRIP10.4.982−0.4.9530.8.8
      CRIP2−0.7.9−0.3.919−0.4.688
      CRK−0.4.947−0.3.906−0.1.943
      CRKL−0.4.903−0.7.6320.3.72
      CRLF10.4.9410.1.9760.3.739
      CRP−0.8.9−1.4.5190.6.665
      CRYAB−0.8.862−0.4.824−0.4.697
      CRYL1−0.8.9−0.6.815−0.3.844
      CRYZ−0.4.9−0.7.5830.3.701
      CS0.4.90.2.9170.2.746
      CSDE1−2.857−1.8.451−0.3.881
      CSK0.4.927−0.1.9730.5.533
      CSPG4−0.5.9−0.2.942−0.4.628
      CSPG5−1.9−0.8.808−0.3.898
      CSRP1−0.8.878−0.6.808−0.3.811
      CSRP2−1.2.857−0.8.762−0.5.694
      CSTB−0.3.903−0.7.4430.4.43
      CTGF0.9.8620.1.9880.8.33
      CTHRC11.8570.2.9420.9.147
      CTNNA10.3.9820.1.9880.2.953
      CTNND10.3.963−0.2.9330.4.561
      CTPS1−0.3.966−0.2.919−0.1.951
      CTSB0.3.969−0.3.8980.6.487
      CTSC−0.1.984−0.9.5190.9.182
      CTSD0.1.982−0.6.5830.6.164
      CTSF−0.7.9−0.4.826−0.3.757
      CTSG0.6.90.7.721−0.2.916
      CTSZ0.2.9740.1.9850.2.87
      CTTN0.1.990.3.826−0.3.697
      CUL90.4.982−1.4.7071.7.198
      CUTA−0.5.903−0.9.5830.4.676
      CXCL12−0.2.9820.1.985−0.2.863
      CXCL16−0.6.927−0.6.826−0.11.00
      CYB5R1−0.1.99−0.2.9530.1.933
      CYB5R3−0.4.947−0.5.7990.2.873
      CYBRD1−0.9.9−1.3.5190.5.703
      CYCS0.6.9−0.2.9330.7.307
      CYFIP1−0.2.982−0.1.962−0.1.978
      CYP20A1−0.3.982−0.8.8480.6.797
      CYP27B10.7.903−1.3.5521.9.037
      CYP2C8−0.4.982−0.5.9170.1.983
      DAAM20.7.9410.2.9560.5.8
      DAD1−0.4.9740.2.966−0.5.726
      DAG1−0.8.862−0.3.868−0.5.511
      DARS10.1.9820.2.892−0.2.814
      DBI−0.4.9−0.3.866−0.2.806
      DBN10.3.966−0.2.9340.4.578
      DBNL0.1.997−0.6.5830.6.199
      DCN1.3.857−0.5.8211.8.022
      DCPS0.2.979−0.6.6790.7.161
      DCTN1−0.1.9920.1.985−0.1.952
      DCTN2−0.1.982−0.4.7920.3.658
      DCTN3−0.4.941−0.4.8210.1.974
      DDAH1−0.5.941−0.5.8260.1.998
      DDAH2−0.5.862−0.6.6090.1.958
      DDB1−0.2.982−0.4.8260.3.762
      DDOST0.2.981−0.4.8080.5.346
      DDR1−1.2.862−0.5.89−0.8.571
      DDT−0.3.941−1.3240.8.198
      DDX1−0.2.979−0.5.8020.3.757
      DDX250.2.9820.4.84−0.3.788
      DDX39B−0.5.941−0.4.878−0.1.957
      DDX3X0.2.9820.5.792−0.4.676
      DDX60.5.9460.4.8820.1.974
      DECR10.6.90.1.990.6.442
      DES0.1.984−0.7.7130.7.306
      DHAK0.2.974−0.2.9220.4.623
      DHRS7−0.4.9820.3.946−0.6.719
      DHX37−1.9.857−1.758−0.9.441
      DHX9−0.2.982−0.3.9170.2.915
      DIABLO−0.3.966−0.1.975−0.3.827
      DKK3−0.2.982−0.5.8260.4.757
      DLAT−0.1.982−0.2.9170.1.939
      DLGAP1−0.5.969−0.6.8530.2.95
      DLST0.1.982−0.1.9890.1.93
      DMD−0.5.9−0.2.922−0.3.705
      DNAH5−0.9.9−1.4.4570.6.613
      DNAH9−2.4.857−1.8.451−0.7.678
      DNAJA2−0.1.982−0.2.8920.2.84
      DNAJB110.6.9030.2.9420.4.706
      DNAJB4−0.4.927−0.4.82−0.11.00
      DNM1L0.3.9570.2.9420.2.889
      DNPEP−0.3.972−0.3.917−0.1.991
      DNTTIP1−1.5.857−0.7.792−0.8.447
      DNTTIP2−0.5.927−0.6.7920.2.915
      DPP30.3.941−0.3.8260.6.286
      DPT−0.1.992−0.8.7180.8.363
      DPYSL2−0.1.982−0.4.8120.3.642
      DPYSL3−0.4.9−0.4.7590.1.934
      DRAP10.2.982−0.3.8480.4.529
      DSCAM−1.6.8620.2.976−1.8.198
      DSP0.2.982−0.4.8620.6.598
      DST−0.8.903−1.7660.3.906
      DSTN−0.6.9−0.5.759−0.1.962
      DTWD2−0.2.9820.7.846−0.8.581
      DUSP3−0.6.878−0.6.6740.1.975
      DUT0.2.982−0.3.9330.4.785
      DYNC1H1−0.3.9690.1.964−0.4.691
      DYNC1I2−0.3.966−0.4.8260.2.917
      DYNC1LI1−0.1.9860.1.973−0.2.913
      DYNC1LI2−0.2.974−0.2.933−0.1.977
      DYNLRB1−0.2.982−0.5.8260.4.779
      ECH10.2.982−0.9.3461.1.037
      ECHS1−0.1.982−0.4.8080.4.65
      ECM1−0.1.982−0.2.9330.1.945
      EEA10.2.982−0.1.9610.2.759
      EEF1A20.2.982−0.8.7210.9.234
      EEF1B2−0.2.982−0.6.7590.4.623
      EEF1D0.1.982−0.5.7210.5.301
      EEF1DP3−1.3.862−1.5.5310.3.901
      EEF1G0.1.9820.1.9930.1.962
      EEF20.1.982−0.1.9730.2.824
      EFEMP1−0.9.862−0.2.933−0.7.447
      EFEMP2−0.5.9−0.4.808−0.1.978
      EFHD1−0.5.903−0.4.848−0.2.913
      EFHD20.6.9−0.4.8610.9.172
      EFL1−0.3.957−0.6.7910.3.791
      EGR4−1.1.9−1.1.750.1.97
      EHD1−0.1.982−0.1.9510.1.962
      EHD2−1.857−0.6.789−0.4.623
      EHD3−0.7.9−0.1.974−0.7.463
      EHD4−0.4.9−0.3.821−0.1.899
      EIF1−0.3.957−0.7.5080.5.372
      EIF2A−0.5.90.2.92−0.6.313
      EIF2B1−0.4.9410.3.876−0.7.341
      EIF2S1−0.1.982−0.3.80.2.703
      EIF2S30.2.9820.3.891−0.2.899
      EIF3A−0.3.9820.3.899−0.5.567
      EIF3F0.3.941−0.4.8260.7.301
      EIF3I0.1.99−0.5.8170.5.557
      EIF4A1−0.2.982−0.2.9510.1.983
      EIF4A2−0.2.972−0.4.7920.3.776
      EIF4A3−0.1.994−0.3.8990.3.8
      EIF4B0.2.982−0.1.9880.2.887
      EIF4G2−0.3.972−0.2.951−0.2.93
      EIF4G3−0.3.982−2.2251.8.035
      EIF4H−0.3.972−0.1.998−0.3.821
      EIF5−0.5.9−0.5.7920.11.00
      EIF5A−0.3.976−0.7.7910.5.697
      EIF6−0.5.927−0.8.6680.4.704
      ELANE−0.4.941−0.3.917−0.2.902
      ELAVL1−0.2.982−0.2.939−0.1.998
      ELN−1.8621.634−1.9.022
      ELOB−0.4.941−0.4.8210.1.966
      EMD−0.7.9−0.2.951−0.6.48
      EMILIN1−0.8.8570.3.88−1.035
      EMILIN20.1.982−0.2.9530.3.84
      EML2−0.6.878−0.7.4970.2.792
      EML30.1.997−0.3.9440.3.891
      ENAH−0.3.947−0.2.942−0.2.863
      ENAM−0.8.9−0.7.782−0.2.913
      ENDOD1−0.1.984−0.2.9340.2.905
      ENG−0.1.9820.2.922−0.3.741
      ENO1−0.4.9−0.2.826−0.2.757
      ENO2−0.4.862−0.2.848−0.3.65
      ENOPH1−0.3.974−0.8.7850.5.697
      ENPP1−0.1.9840.2.917−0.3.785
      ENPP20.2.982−0.2.9370.4.688
      EPB41L20.1.9820.2.957−0.1.968
      EPDR1−0.3.96−0.3.891−0.11.00
      EPHX1−0.2.982−0.9.3270.8.112
      EPPK1−0.1.99−0.2.9660.1.958
      EPRS10.3.9690.2.9340.1.944
      EPS15L10.1.993−0.11.000.1.991
      EPS8L1−1.9−0.9.792−0.2.955
      ERBIN−1.857−0.5.826−0.6.463
      ERC20.9.9−1.1.672.035
      ERH−0.1.982−0.3.8990.2.84
      ERI1−0.9.957−1.2.8220.3.928
      ERLIN2−0.3.9470.2.933−0.5.509
      ERO1A−0.6.927−0.7.7920.2.913
      ERP290.1.982−0.4.7740.5.337
      ERP440.1.982−0.6.6990.7.286
      ES1−0.4.941−0.6.7640.2.824
      ESD−0.4.903−0.6.6540.3.757
      ESYT1−0.1.997−0.2.9510.2.903
      ESYT2−0.5.903−0.4.853−0.2.899
      ETF1−0.1.988−0.3.8650.3.757
      ETFA0.3.963−0.6.6740.8.112
      ETFB0.4.927−0.3.8610.6.286
      EXOC3−0.8.9−0.8.7590.11.00
      EXT1−0.6.9120.3.933−0.8.394
      EYS−1.1.90.8.8−1.9.071
      EZR0.2.972−0.1.9880.2.75
      F100.2.982−1.2.5121.4.106
      F11−0.8.9−0.3.917−0.5.641
      F12−0.1.982−0.4.8210.3.726
      F13A10.2.982−0.5.7920.6.378
      F13B0.1.984−0.8.6320.8.21
      F2−0.2.972−0.5.6740.4.526
      F9−1.857−0.5.769−0.5.495
      FABP1−0.2.982−0.3.9120.2.93
      FABP3−0.9.862−1.5830.2.913
      FABP4−0.4.957−0.7.7370.4.701
      FABP50.3.982−0.8.6741.1.16
      FAH−0.3.941−0.6.5380.4.494
      FAM135A0.1.984−0.2.9530.3.875
      FAM180A−1.2.90.6.862−1.8.132
      FAM50B−1.1.9−0.4.911−0.8.578
      FANCA−0.2.9820.9.769−1.341
      FANK10.5.947−1.2.6321.7.08
      FARSB−0.1.982−0.2.9530.1.991
      FASN0.4.941−0.2.9340.6.483
      FAU−0.1.982−0.9.6740.8.355
      FBLIM1−0.8.862−0.4.831−0.4.658
      FBLN1−0.6.862−0.6.5830.1.97
      FBLN20.1.993−0.5.8190.5.578
      FBLN5−1.3.8570.1.994−1.3.102
      FBN1−1.2.8570.5.826−1.6.036
      FCGBP0.2.982−0.1.9730.2.862
      FCGR3A−0.6.927−1.6320.5.674
      FDPS−0.2.974−0.3.8990.1.97
      FERMT2−0.8.862−0.3.899−0.6.427
      FERMT30.6.90.5.8150.2.881
      FGA−0.2.9820.4.847−0.5.537
      FGB−0.1.9920.5.826−0.6.624
      FGG0.2.9820.5.826−0.4.739
      FGL2−0.3.972−0.5.8080.3.811
      FH0.2.982−0.7.7690.9.286
      FHL1−1.1.857−0.6.815−0.6.526
      FHL2−0.6.9−0.6.7590.1.964
      FHL3−0.5.9−0.4.821−0.2.917
      FHL5−0.1.9840.2.933−0.2.824
      FIGNL1−0.1.9930.6.826−0.7.638
      FILIP1L0.1.9820.3.826−0.2.787
      FIS10.1.982−0.7.6740.7.199
      FKBP1A−0.5.9−0.7.590.3.744
      FKBP20.1.982−0.4.8150.4.486
      FKBP30.5.903−0.1.9930.6.514
      FKBP40.4.90.3.8360.2.891
      FKBP50.8.9−0.6.8081.3.103
      FKBP9−0.6.929−0.2.973−0.5.726
      FLAD1−0.6.9570.2.985−0.8.688
      FLII−0.5.903−0.3.853−0.2.878
      FLNA−0.5.90.2.933−0.6.324
      FLNB0.5.941−0.2.9520.6.529
      FLNC−0.5.90.2.917−0.7.248
      FLOT1−0.1.9820.2.826−0.3.539
      FLOT2−0.3.9690.3.862−0.5.441
      FMOD−0.6.903−0.5.826−0.2.931
      FN1−0.4.90.1.956−0.5.372
      FN3K−1.1.9−2.2.3231.1.401
      FOXL1−0.2.982−1.1.5381.259
      FRMD6−0.4.969−1.5880.7.441
      FRZB−0.5.941−0.3.933−0.3.855
      FSCN1−0.1.99−0.5.8150.5.596
      FSIP2−0.6.916−0.7.7890.2.916
      FSTL1−0.3.947−0.1.965−0.2.818
      FTH10.6.9030.1.9930.6.592
      FUBP10.1.984−0.2.9420.3.852
      FUCA10.2.982−0.9.3911.04
      FURIN0.1.993−0.4.9330.4.844
      G6PD0.1.9880.2.897−0.2.811
      GAA−0.2.979−0.7.6050.5.405
      GALM0.1.993−0.6.6790.6.301
      GANAB−0.1.986−0.1.9330.1.899
      GAPDH−0.3.941−0.4.8080.1.916
      GAPDHS−0.4.979−0.7.8260.3.851
      GARS10.5.9290.1.9980.5.652
      GART−0.4.947−0.5.8310.1.975
      GAS6−0.2.982−0.8.6740.7.403
      GASK1B−0.6.9−0.1.988−0.6.543
      GBA0.4.9690.4.882−0.1.98
      GBE1−0.8.862−0.2.934−0.7.311
      GBLP0.3.941−0.1.9530.4.543
      GBP1−0.5.927−0.7.7420.3.825
      GC−0.2.982−0.7.5080.5.286
      GCA0.1.9820.7.759−0.6.447
      GCLC0.4.9−0.7.5111.1.023
      GDI1−0.5.9−0.7.6310.2.855
      GDI2−0.1.982−0.3.8080.2.669
      GFPT1−0.3.9720.3.899−0.6.526
      GFUS0.1.990.2.951−0.1.93
      GGT5−0.6.9−1.4680.5.543
      GJA1−0.5.9120.1.998−0.5.572
      GLDC−0.5.941−1.8.2641.3.133
      GLIPR2−0.5.9−0.5.792−0.1.998
      GLO1−0.3.9−0.6.4510.3.561
      GLOD4−0.3.944−0.8.4210.5.301
      GLRX0.2.982−0.7.6110.8.151
      GLS−0.4.946−0.3.899−0.1.945
      GLUD10.2.9720.1.9750.2.877
      GM2A0.3.982−1.2.4861.4.068
      GMFG0.3.972−0.3.9330.6.613
      GNA11−0.9.9−0.5.847−0.4.795
      GNA13−0.1.984−0.8.7620.7.451
      GNAI2−0.3.966−0.2.906−0.1.974
      GNAI3−0.1.982−0.1.9720.1.979
      GNAQ−0.1.9840.3.915−0.3.779
      GNB1−0.3.947−0.3.8530.11.00
      GNB2−0.2.969−0.4.7920.2.788
      GNB4−0.4.927−0.4.7920.1.931
      GNG12−0.5.941−0.5.83−0.1.998
      GNPDA1−0.2.982−0.3.9220.1.962
      GNPTAB−0.8.9−0.8.785−0.1.963
      GOLM1−0.6.966−1.1.8020.5.825
      GOT1−0.1.992−0.4.8260.4.658
      GOT2−0.1.988−0.6.7180.6.378
      GPBP1L1−2.857−0.2.966−1.8.195
      GPC40.1.997−0.6.7920.6.509
      GPC6−0.5.941−0.4.862−0.1.958
      GPD1L−0.4.941−0.5.7920.2.878
      GPI−0.3.9−0.3.792−0.1.961
      GPM6A−0.7.9030.2.953−0.9.409
      GPNMB0.9.9−0.3.9331.2.296
      GPX1−0.1.982−0.7.5510.7.266
      GPX3−0.4.912−0.4.822−0.1.974
      GPX40.2.982−0.4.8740.6.572
      GRB20.1.982−0.7.5080.7.106
      GRB7−0.1.982−0.4.7920.3.598
      GRHPR−0.2.972−0.4.8080.2.812
      GRP780.2.9730.3.821−0.2.84
      GSN−0.2.946−0.3.8260.1.974
      GSR0.2.972−0.1.9170.2.581
      GSS0.4.947−1.6321.4.083
      GSTM2−0.4.941−0.7.7620.3.814
      GSTM3−0.5.9−0.6.6770.1.913
      GSTO10.1.982−0.2.8430.3.498
      GSTP1−0.4.9−0.2.917−0.2.682
      GSTT1−0.5.903−0.5.7920.1.99
      GUK1−0.6.9−0.6.815−0.1.962
      GULP1−0.1.9820.3.907−0.3.753
      GYG1−0.5.903−0.7.6790.2.822
      H1-0−0.3.941−0.3.866−0.1.976
      H1-50.4.974−0.4.9170.7.593
      H2AC210.2.982−0.2.9330.4.669
      H3-3A−0.7.9−0.7.7550.1.987
      H4-16−0.3.982−0.8.7890.6.652
      HAAO−0.9.857−1.3460.1.938
      HABP2−0.2.982−0.4.8180.3.757
      HADH0.3.922−0.3.8140.6.178
      HADHA−0.1.984−0.3.8220.3.676
      HADHB−0.1.997−0.2.8470.2.697
      HAGH0.1.982−0.3.7550.4.316
      HAPLN1−0.6.9−0.2.953−0.5.646
      HAPLN3−1.1.862−0.5.826−0.6.567
      HARS2−0.5.941−0.5.8250.1.971
      HBA10.9.862−0.6.7921.5.032
      HBB0.6.9−0.9.5831.4.035
      HBD0.5.903−0.7.6741.2.066
      HBZ1.1.862−0.7.8081.8.038
      HDGF−0.4.903−0.1.961−0.3.688
      HDGFL3−0.5.941−1.6160.6.567
      HDHD20.1.982−0.4.8210.4.526
      HDLBP−0.1.982−0.3.8970.2.863
      HEBP1−0.2.969−0.7.4010.6.21
      HEBP2−0.6.9−0.5.792−0.1.945
      HEXA0.5.9030.6.762−0.1.931
      HEXB−0.1.982−0.6.6740.5.399
      HIBADH−0.4.903−0.9.4760.5.486
      HIBCH0.1.982−0.4.7920.5.372
      HINT1−0.3.957−0.9.3270.7.185
      HK10.1.9920.1.973−0.1.962
      HKDC10.7.9−1.6681.7.044
      HLA-DRA0.6.9−0.4.8261.104
      HLCS0.7.9030.2.9730.6.652
      HMCN1−0.7.90.1.98−0.8.342
      HMGB2−0.2.9820.5.753−0.6.234
      HMGCS20.2.982−0.6.8260.8.518
      HNRNPA10.8.90.8.718−0.1.951
      HNRNPA2B10.1.9820.1.9870.1.994
      HNRNPA3−0.1.982−0.1.992−0.1.987
      HNRNPAB0.3.941−0.4.7640.7.137
      HNRNPC−0.1.982−0.8.7080.7.426
      HNRNPD−0.1.99−0.3.8340.3.703
      HNRNPF0.4.974−0.3.9340.6.658
      HNRNPH3−0.2.969−0.1.989−0.2.811
      HNRNPK−0.2.974−0.4.780.2.688
      HNRNPL0.1.9820.1.9890.1.974
      HNRNPM0.3.930.2.8620.1.95
      HNRNPR0.2.974−0.2.9170.3.593
      HNRNPU−0.3.982−0.6.7920.4.691
      HNRNPUL2−0.3.982−0.3.9410.11.00
      HP−1.1.862−1.6.3910.5.704
      HP1BP3−0.2.982−0.2.9330.1.968
      HPR−0.2.982−1.5.2881.4.068
      HPRT10.4.941−0.4.8260.7.287
      HPX−0.1.982−0.9.4010.8.112
      HRG−0.5.867−0.2.899−0.4.557
      HSD17B100.3.941−0.4.8180.6.228
      HSD17B12−0.2.9720.1.989−0.2.783
      HSD17B3−0.7.9−0.7.7890.1.979
      HSD17B40.4.941−0.2.9330.6.48
      HSF11.5.862−1.3.7552.7.036
      HSP90AA1−0.3.93−0.2.891−0.1.917
      HSP90AB1−0.5.9−0.1.988−0.5.416
      HSP90B10.1.982−0.1.9420.2.754
      HSPA2−1.857−0.6.792−0.5.587
      HSPA40.2.982−0.5.8210.6.441
      HSPA4L0.4.969−0.2.9720.5.688
      HSPA50.2.941−0.1.9980.2.658
      HSPA80.1.982−0.2.8220.3.529
      HSPA9−0.1.993−0.3.8210.3.627
      HSPB1−0.6.9−0.5.808−0.2.889
      HSPB6−0.6.9−0.9.6680.3.797
      HSPB7−0.9.862−0.7.75−0.2.878
      HSPB8−0.6.90.1.993−0.7.487
      HSPD10.2.947−0.2.9170.3.486
      HSPE10.2.982−0.7.5920.8.133
      HSPG2−0.7.8620.2.934−0.9.144
      HTR3C0.4.97−0.8.7621.2.199
      HTRA1−0.5.941−0.6.820.1.961
      HV206−1.2.9−1.9.4620.8.633
      HV209−0.5.947−1.7.3771.2.234
      HV306−0.8.9−1.9.3231.1.324
      HYOU10.4.9270.3.9070.2.862
      IAH1−0.4.9−0.5.7590.1.922
      IARS10.2.982−0.1.9730.2.792
      IARS2−0.5.903−0.1.973−0.5.65
      IDH1−0.2.981−0.4.6530.3.451
      IDH20.3.9410.2.9330.2.87
      IDH3A0.2.982−0.6.7590.7.247
      IDNK2.857−0.7.8262.7.019
      IER5−0.3.974−1.5260.8.328
      IFT46−0.3.957−1.3.2871.133
      IGDCC3−0.6.9591.3.727−1.8.147
      IGF2−0.8.862−0.9.490.2.894
      IGFALS−0.1.982−0.9.5860.8.28
      IGFBP2−0.5.929−0.3.899−0.2.89
      IGFBP3−0.7.90.2.946−0.9.325
      IGFBP5−0.7.90.1.981−0.7.344
      IGFBP6−0.1.99−0.3.90.3.82
      IGFBP7−1.1.857−0.2.951−1.203
      IGHA1−0.4.93−1.4.2371.135
      IGHA2−0.5.927−1.6.2861.1.19
      IGHD0.1.988−0.9.7550.9.36
      IGHG1−0.7.862−1.2.2830.5.429
      IGHG2−0.8.862−1.4.3020.6.487
      IGHG3−0.1.984−0.3.8990.3.825
      IGHG4−0.8.9−1.2.5190.4.751
      IGHM−0.3.972−1.5.2871.3.104
      IGHV2-70D−0.3.982−0.7.8260.4.818
      IGHV3-20−0.5.947−0.8.7420.4.72
      IGHV3-49−0.4.957−1.8.2251.4.089
      IGHV3-64D−0.6.9−1.4.2970.8.286
      IGHV3-7−0.7.9−1.5.2250.9.204
      IGHV3-72−0.8.9−1.4.3270.7.466
      IGHV3-74−0.6.9−1.8.2251.2.111
      IGHV6-1−0.2.982−1.3.5921.1.328
      IGKC−0.4.903−1.2.2250.8.156
      IGKV1-12−1.2.862−1.5.4570.3.862
      IGKV1-16−0.4.947−1.6.3231.2.164
      IGKV1-6−0.3.972−1.1.5080.8.312
      IGKV2-24−0.4.947−1.6.2251.3.055
      IGKV3-20−0.6.899−1.2.2620.6.372
      IGKV3D-15−0.4.965−2.2251.7.035
      IGKV3D-20−0.7.9−1.9.2251.3.123
      IGKV4-1−0.6.9−1.6.2251.137
      IGLC7−0.6.903−1.6.2251.1.151
      IGLL1−0.5.9−1.3910.5.447
      IGLL5−0.5.941−2.6.2252.1.023
      IGLV1-47−0.4.958−1.7.2251.4.07
      IGLV1-51−1.2.878−1.7.4320.6.688
      IGLV3-1−0.8.9−1.8.2251.1.176
      IGLV3-12−0.6.9−1.4.2250.8.247
      IGLV3-19−0.8.9−1.5.2350.8.328
      IGLV4-3−0.6.954−1.2.6820.7.644
      IGLV8-61−0.6.927−0.6.8140.1.968
      IL12RB1−1.1.91.792−2.1.083
      IL1RAPL1−0.7.927−2.2.2351.6.133
      IL1RL10.1.982−1.4.5531.5.156
      IL34−0.2.9820.7.742−0.9.213
      IL4I10.2.972−0.7.5260.9.071
      ILF20.3.982−0.2.9420.5.698
      ILK−0.6.8620.1.957−0.7.179
      IMMT0.1.9860.2.902−0.2.827
      IMPA1−0.5.927−1.4520.6.413
      IMPDH2−0.6.9−0.4.872−0.3.757
      IMPG1−1.903−0.6.866−0.4.857
      INF20.3.982−0.5.8990.7.674
      INKA10.6.903−0.7.781.2.103
      IPO50.2.9820.1.9610.1.945
      IPO7−0.2.974−0.11.00−0.2.828
      IPO9−0.1.982−0.2.9450.1.968
      IQGAP1−0.2.969−0.2.8590.1.962
      IRGC−0.6.9440.6.826−1.1.306
      ISLR0.1.997−0.3.9130.3.812
      ISYNA1−0.6.903−0.5.857−0.2.899
      ITGA1−0.9.857−0.4.826−0.6.488
      ITGA11−0.4.947−0.1.987−0.4.762
      ITGA3−0.8.8620.1.998−0.8.212
      ITGA5−0.6.9−0.2.951−0.5.572
      ITGA7−0.8.857−0.4.821−0.4.537
      ITGA8−0.8.862−0.2.944−0.7.36
      ITGAV−0.3.957−0.1.998−0.3.733
      ITGB1−0.6.9−0.4.826−0.3.795
      ITGB20.3.9690.3.865−0.1.968
      ITGB30.2.9820.9.592−0.7.343
      ITGB5−0.2.972−0.3.90.1.99
      ITIH1−0.1.982−0.7.6790.6.401
      ITIH20.3.947−0.5.7760.7.177
      ITIH3−0.1.997−0.7.6320.7.261
      ITIH4−0.3.946−1.1.2250.8.089
      ITIH5−0.9.857−0.6.713−0.3.792
      ITM2B−0.6.9−0.5.816−0.2.906
      ITPR1−0.6.9−0.1.972−0.5.503
      IVD0.1.9860.3.913−0.3.844
      IVNS1ABP−0.2.9820.1.964−0.3.757
      JCHAIN−0.1.997−1.2.2861.2.044
      JMY−1.3.862−0.7.826−0.7.676
      K132L−1.2.862−1.718−0.2.902
      KANK2−0.6.9−0.3.916−0.4.593
      KANSL30.5.941−1.3.3911.8.023
      KAT6B−0.8.9−0.2.941−0.6.528
      KAT8−1.4.862−1.1.75−0.4.84
      KCNF1−0.1.992−1.8150.9.596
      KCTD120.1.982−0.6.70.7.276
      KDEL2−0.1.9820.1.993−0.1.956
      KHSRP0.1.9820.1.966−0.1.998
      KIF26B−0.1.984−1.9.6321.8.286
      KIF2A−0.7.941−0.7.826−0.11.00
      KIF5B−0.1.9970.2.966−0.2.93
      KLB−0.2.969−0.2.931−0.1.962
      KLC1−0.2.982−0.3.8910.2.901
      KLF10−0.4.957−0.2.973−0.3.825
      KLKB1−0.2.982−0.8.5830.6.324
      KMT5C−0.8.857−0.3.858−0.5.438
      KNG1−0.1.982−0.8.3460.7.113
      KNTC1−0.9.9−1.4.5380.6.697
      KPNB1−0.2.982−0.4.8080.3.719
      KREMEN20.2.982−1.7611.2.328
      KRT10.5.9030.1.9980.5.561
      KRT100.3.9690.2.9340.2.931
      KRT18−0.6.903−1.2.4740.6.519
      KRT19−0.9.857−1.3.2250.4.638
      KRT20.2.982−0.5.8180.7.408
      KRT7−0.2.982−0.6.7920.4.707
      KRT730.4.9410.4.8470.1.989
      KRT770.7.9410.1.9880.6.719
      KRT8−0.7.862−1.2.3230.5.506
      KRT90.2.982−0.1.9730.2.818
      KSR2−0.4.972−1.7.3231.4.123
      KTN1−0.1.982−0.4.8150.3.666
      KV204−0.5.903−1.3.2530.9.179
      KV304−0.2.982−1.9.2251.5.061
      KV308−0.1.982−1.5.5831.3.286
      KY−1.9−1.2.5921.1.273
      LACTB20.6.9−1.4.3910.5.705
      LAMA2−0.4.941−0.4.916−0.6.676
      LAMA4−0.5.9030.1.9890.5.363
      LAMA5−0.9.857−0.3.913−0.2.916
      LAMB1−0.5.927−1.4920.5.529
      LAMB2−0.9.8570.1.953−1.066
      LAMC1−0.7.862−0.2.933−0.3.824
      LAMP10.2.9570.2.933−1.1.043
      LAMP20.3.927−0.1.965−0.6.328
      LAMTOR10.1.982−0.3.7920.5.216
      LAMTOR30.3.944−0.1.9890.3.581
      LANCL1−0.6.9−0.1.9650.2.84
      LAP30.3.9270.3.826−0.1.968
      LASP1−0.4.941−0.4.826−0.3.742
      LBP−0.7.9−0.8.4211.1.023
      LBX1−0.2.982−0.5.8080.2.906
      LCA5L−0.4.982−0.6.792−0.2.889
      LCP10.2.974−0.7.8150.5.688
      LDB3−0.8.8620.6.916−1.675
      LDHA−0.4.9−0.3.9170.4.591
      LDHAL6A−0.8.9−0.3.891−0.5.557
      LDHB−0.2.974−0.4.792−0.1.99
      LDLR−0.2.982−1.1.5380.4.757
      LECT2−0.4.974−0.4.7420.3.598
      LEFTY2−0.7.9−0.9.6320.7.393
      LEMD2−0.5.9270.1.99−0.4.796
      LETM10.2.9820.11.00−0.7.517
      LGALS1−0.5.9−0.8.6740.4.719
      LGALS30.2.9820.2.919−0.1.968
      LGALS3BP0.2.982−0.4.792−0.1.913
      LHPP0.1.99−0.6.5830.7.11
      LIMS1−0.4.9120.1.9610.1.968
      LIMS2−0.5.9−0.6.7530.6.363
      LMAN2−0.1.996−0.3.882−0.2.887
      LMCD1−0.8.862−0.4.805−0.1.962
      LMNA−0.4.927−0.2.9510.2.913
      LMNB1−0.3.972−0.3.906−0.6.496
      LMNB2−0.4.9−0.5.8080.1.957
      LMOD1−0.8.8620.2.953−0.4.688
      LOXL1−1.2.857−0.3.821−0.1.912
      LPA0.2.982−0.1.973−0.7.363
      LPCAT2−0.2.9720.3.917−1.4.037
      LPP−0.8.862−1.9.2252.019
      LRG1−0.3.941−0.4.7920.2.765
      LRP1−0.3.927−0.2.951−0.7.343
      LRP12−1.9.857−1.1.2860.8.152
      LRP6−0.6.947−0.3.839−0.1.968
      LRPAP1−0.5.927−0.7.826−1.3.308
      LRRC47−0.2.982−0.2.961−0.4.824
      LRRC591.1.857−0.5.8080.1.962
      LRRC72−1.9−0.3.8660.2.839
      LRRC90.7.90.5.8210.6.452
      LSM3−0.1.9820.7.826−1.6.179
      LSM60.2.982−0.1.9850.8.313
      LSM70.2.982−0.9.4060.8.133
      LSM80.4.9720.1.9730.1.961
      LTA4H−0.1.982−0.5.8950.6.68
      LTBP1−0.9.857−0.6.8261.383
      LTBP2−0.7.8620.1.973−0.2.825
      LTBP4−1.1.8570.1.956−1.075
      LTF−0.5.947−0.5.785−0.3.792
      LUM0.3.9720.1.99−1.1.106
      LV106−0.5.9570.1.993−0.5.699
      LXN0.4.969−1.1.4971.4.066
      LYPLA10.9.862−0.9.7590.5.734
      LYST−0.6.9−1.3.5261.6.068
      LYZ−0.6.9−0.1.9980.9.286
      LZIC−0.1.982−1.9.2251.3.072
      LZTR1−0.2.982−0.4.822−0.2.844
      MACF1−0.1.982−0.6.5860.6.264
      MACROH2A1−0.2.982−0.7.8150.6.688
      MAGEE1−1.2.8620.3.905−0.3.729
      MAGEH10.2.982−0.5.7920.4.676
      MAMDC2−0.1.9970.6.826−1.7.053
      MAOA−0.3.972−0.4.8190.6.391
      MAOB−0.3.957−0.2.9530.2.917
      MAP1B−0.2.972−0.6.7920.3.785
      MAP4−0.1.982−0.4.8260.1.952
      MAPK1−0.2.9820.2.917−0.4.572
      MAPK10−1.1.9−0.1.9730.1.998
      MAPRE1−0.1.982−0.7.4740.6.206
      MARCKS0.3.957−0.1.989−1.543
      MAST3−0.7.9−0.3.8220.3.72
      MAT2B−0.1.982−0.3.8660.6.402
      MB−0.4.947−0.7.7180.1.961
      MCAM−0.7.862−0.4.8440.3.779
      MCEMP11.1.9030.4.904−0.8.452
      MDFIC0.2.982−0.6.713−0.1.921
      MDH1−0.1.982−0.1.9981.1.526
      MDH20.3.941−1.2.5381.3.123
      MDM1−1.2.857−0.7.5860.6.311
      ME10.1.982−0.6.6770.8.096
      ME2−0.2.982−0.1.986−1.2.172
      MECP2−0.2.982−0.8.8150.9.512
      MEGF6−0.2.982−0.6.8080.5.675
      MESD0.3.969−0.1.956−0.1.968
      METRNL−0.2.9820.6.792−0.7.307
      METTL25−1.1.9−0.4.8530.6.438
      METTL7A−0.8.90.4.905−0.5.719
      MFAP2−1.862−1.8.3640.8.553
      MFAP4−1.1.862−1.1.5530.4.76
      MFAP50.1.9970.2.951−1.2.128
      MFGE8−1.862−0.5.861−0.6.602
      MGP−1.2.862−0.7.6770.7.306
      MGST3−0.1.982−0.2.951−0.8.363
      MIF−0.5.9−0.6.834−0.7.587
      MINPP11.1.862−0.4.8990.3.857
      MLH10.8.9−0.4.818−0.1.91
      MLKL−0.6.927−0.3.9141.4.083
      MLTK−0.3.957−0.4.8991.1.172
      MMP20.1.997−0.8.7440.3.829
      MMP9−0.2.9820.1.973−0.4.653
      MMRN10.6.9−0.1.9780.1.953
      MOCS2−0.6.8640.4.891−0.6.624
      MOS0.1.991.1.438−0.6.526
      MPDZ0.4.927−0.5.759−0.1.917
      MPO−0.4.966−0.4.9330.4.835
      MPST−0.2.972−0.8.6421.2.066
      MRC20.1.9821.583−1.4.071
      MRVI1−0.2.982−1.2.2251.071
      MSN−0.3.927−0.2.9510.3.818
      MSRB3−0.5.9410.1.966−0.3.8
      MST10.2.982−0.1.962−0.2.705
      MT-CO2−0.7.9−1.4.3461.247
      MTHFD1−0.1.9880.3.917−0.2.931
      MTPN−0.2.972−0.5.84−0.3.84
      MVP−0.2.965−0.3.8920.3.797
      MYADM−0.7.9−0.7.480.6.286
      MYCBP2−0.7.941−0.2.917−0.1.957
      MYDGF0.3.9720.6.815−1.3.115
      MYH10−0.9.862−1.5.6740.8.654
      MYH11−1.2.857−0.3.9130.6.549
      MYH13−0.6.912−0.2.956−0.8.306
      MYH14−0.7.9−0.2.951−1.157
      MYH2−0.6.9−0.4.898−0.3.862
      MYH9−0.2.982−0.2.947−0.6.59
      MYL6−0.9.857−0.3.899−0.3.791
      MYL6B−1.1.8570.3.891−0.4.563
      MYL9−0.7.878−0.4.826−0.5.457
      MYLK−0.5.9−0.3.899−0.8.35
      MYO18A0.2.982−0.4.815−0.3.787
      MYO1C−0.6.878−0.4.826−0.2.84
      MYO1D−0.3.957−0.5.8990.6.707
      MYO5B−0.3.982−0.2.919−0.5.526
      MYOF−0.2.982−0.2.951−0.2.862
      MYOM2−0.2.9820.5.895−0.7.654
      MYOM3−0.8.90.1.974−0.3.787
      NAA15−1.5.903−1.2.4741.1.179
      NAGK−0.1.982−0.8.6740.1.97
      NAMPT−0.4.941−3.5.3232.1.307
      NAP1L10.1.982−0.5.670.4.343
      NAP1L4−0.2.9650.4.826−0.8.283
      NAPA0.3.957−0.4.9040.5.722
      NAPG−0.3.969−0.3.8080.2.855
      NAPRT−0.4.941−0.2.9370.4.558
      NARS10.2.982−0.2.933−0.1.951
      NASP−0.5.927−0.7.780.3.84
      NAV1−0.4.9720.2.951−0.1.99
      NAV20.1.9820.5.822−0.9.21
      NAXE−0.8.8890.9.755−1.2.198
      NCKAP1−0.4.941−1.1.6791.1.28
      NCL−0.3.957−0.9.6680.1.962
      NCOA11.2.8620.2.945−0.6.523
      NDRG1−0.2.982−0.5.7890.3.8
      NDRG3−0.2.9820.8.8080.5.734
      NDUFA10−0.4.947−0.3.8990.1.961
      NDUFA13−0.2.982−0.4.8020.3.712
      NDUFA4−0.2.982−1.1.4590.8.341
      NDUFA50.5.9−0.3.9170.1.962
      NDUFA60.2.966−0.3.9170.2.933
      NDUFB11−0.1.9820.3.8620.3.752
      NDUFB4−0.3.974−0.2.9340.3.585
      NDUFS10.3.972−0.2.9520.1.968
      NDUFS3−0.2.982−0.4.8660.1.931
      NDUFS80.2.966−0.5.8210.7.363
      NDUFV2−0.1.982−0.6.8180.5.705
      NECAP2−0.4.982−0.3.8150.5.296
      NEDD8−0.9.862−0.5.7550.5.463
      NEGR1−0.6.9−0.1.985−0.3.898
      NENF−0.6.903−1.6.2250.8.375
      NEXN−0.2.982−0.4.826−0.3.822
      NHSL10.2.982−0.5.826−0.1.955
      NIBAN−0.6.9−0.3.8930.1.933
      NIBL10.1.982−0.8.8261.557
      NID1−0.4.9−0.2.942−0.4.496
      NID2−0.5.9−0.6.7920.7.452
      NIT2−0.3.941−0.5.750.1.943
      NKX1-20.3.982−0.8.5190.4.658
      NLRC4−0.8.9−0.6.6090.3.59
      NLTP0.5.862−0.6.8220.8.451
      NME10.3.972−0.5.822−0.3.84
      NNMT−0.2.982−0.1.9850.5.262
      NOLC10.4.972−0.5.8220.8.363
      NOTCH3−0.6.9−0.3.8950.2.878
      NPC20.1.9820.9.792−0.6.729
      NPEPPS−0.4.9030.1.994−0.7.383
      NPM10.1.982−0.4.8660.5.663
      NPNT−1.2.857−0.7.5260.4.59
      NPTN−0.5.9−0.2.8990.3.657
      NQO2−0.5.9030.2.933−1.4.044
      NRAP−0.9.862−0.3.891−0.3.779
      NSF0.4.903−0.6.770.2.913
      NSFL1C0.1.982−0.8.69−0.1.945
      NSMCE3−0.3.9720.3.8990.2.841
      NT5E−0.3.972−0.5.7920.5.463
      NUCB10.2.969−1.1.3460.9.164
      NUCB2−0.1.988−0.1.989−0.3.846
      NUCKS1−0.9.9−0.2.8910.4.48
      NUDC−0.5.9−0.4.8180.4.63
      NUDT2−0.3.946−1.5.4680.7.572
      NUDT5−0.3.944−0.4.821−0.2.862
      NUTF2−0.2.982−0.3.8480.11.00
      OAF−0.4.982−1.3230.8.179
      OAT0.1.996−0.3.8260.1.863
      OBSCN−2.857−0.1.989−0.3.901
      OGDH0.1.9820.1.993−0.1.998
      OGN−0.6.903−1.815−1.1.466
      OLA1−0.1.982−0.1.9730.2.862
      OLFM1−0.5.946−0.9.6830.3.785
      OLFML10.2.982−0.3.7920.2.707
      OLFML3−0.4.965−1.3.5020.9.394
      OMD0.2.982−0.3.8660.5.523
      OPTN0.1.99−0.7.7730.4.75
      OR10T2−1.1.862−0.4.8620.6.613
      OR4C3−0.2.982−0.4.8530.4.681
      OR51Q1−1.8.857−0.1.975−1.342
      OR56B4−0.6.9410.3.917−0.5.742
      ORM1−0.4.941−1.7.583−0.2.945
      ORM2−0.3.941−0.3.933−0.3.863
      OSTF10.5.9−0.9.4520.6.343
      OTUB1−0.4.941−1.3.2251.053
      OVOS20.5.903−0.2.9040.6.239
      OXCT10.2.982−0.6.7840.2.825
      OXSR10.2.972−0.6.7921.1.123
      P4HB0.2.982−0.1.9850.2.813
      PA2G4−0.1.9970.4.792−0.2.795
      PACSIN2−0.5.90.1.9850.1.898
      PAFAH1B1−0.1.982−0.3.9170.2.825
      PAFAH1B20.1.982−0.5.762−0.1.979
      PAFAH1B30.7.9−0.2.9110.1.934
      PAICS−0.2.972−0.7.4920.8.093
      PALLD−0.4.903−0.5.8151.1.08
      PARK7−0.2.9470.2.951−0.4.685
      PARVA−0.9.857−0.3.826−0.1.945
      PAWR−0.4.947−0.5.5830.3.493
      PBXIP1−0.8.9−0.6.766−0.4.63
      PCBD1−0.4.959−0.2.919−0.2.915
      PCBP10.1.9970.5.847−1.3.145
      PCBP20.4.927−0.5.8260.1.949
      PCDHB14−0.4.941−0.1.9930.1.984
      PCMT10.1.9920.1.9880.3.682
      PCOLCE0.2.966−0.6.7890.2.846
      PCOLCE20.1.982−0.5.5860.6.197
      PCYOX1−0.3.941−0.1.9420.3.602
      PCYT20.5.9270.2.933−0.2.926
      PDAP1−0.5.957−0.6.680.3.688
      PDCD100.5.90.4.8260.1.975
      PDCD50.2.9820.1.989−0.5.705
      PDCD6−0.5.90.3.8720.3.811
      PDCD6IP0.1.99−0.2.8990.4.647
      PDCD7−1.9−0.3.891−0.3.785
      PDGFC−0.7.9270.3.826−0.3.681
      PDHA10.7.9−1.1.6770.1.972
      PDHB0.4.966−0.1.98−0.6.684
      PDIA20.4.972−0.1.9890.7.367
      PDIA30.1.9820.3.9170.1.962
      PDIA40.2.9771.694−0.7.561
      PDIA50.5.9−0.1.9420.2.763
      PDIA60.2.967−0.3.8210.5.388
      PDLIM1−0.4.90.3.8250.2.855
      PDLIM2−0.7.9−0.4.7920.6.261
      PDLIM3−0.8.862−0.4.792−0.11.00
      PDLIM4−0.7.9−0.5.821−0.2.87
      PDLIM5−0.3.969−0.6.792−0.3.825
      PDLIM7−0.9.862−0.4.826−0.3.77
      PDS5A−0.4.912−0.4.8480.1.945
      PDXK−0.2.969−0.6.815−0.4.757
      PEA15−0.4.927−0.7.5890.3.654
      PEBP1−0.4.9−0.8.4570.6.28
      PEF10.3.974−0.5.7550.2.82
      PEPD−0.2.982−0.7.5830.3.691
      PF40.2.9820.7.674−0.5.515
      PFDN1−0.3.972−0.8.2250.7.05
      PFDN2−0.2.9820.4.899−0.3.898
      PFDN5−0.1.982−0.4.8220.2.865
      PFKL−0.2.982−0.6.7890.5.607
      PFKM−0.7.862−0.4.7620.4.509
      PFKP−0.6.90.1.993−0.2.873
      PFN1−0.1.982−0.2.932−0.6.483
      PFN2−0.4.90.3.899−0.8.262
      PGAM1−0.5.9−0.1.9340.1.982
      PGD0.1.9820.1.989−0.4.457
      PGK1−0.3.941−0.5.7890.1.998
      PGK2−0.5.927−0.1.9620.2.827
      PGLS−0.1.982−0.2.872−0.1.968
      PGLYRP2−0.1.982−0.7.750.3.839
      PGM1−0.3.903−0.6.4740.6.185
      PGM2−0.1.982−0.6.6680.6.324
      PGM30.2.982−0.2.892−0.1.851
      PGM5−1.857−0.6.7040.6.372
      PGP−1.1.857−0.3.8530.4.567
      PGRMC1−0.6.9−0.5.808−0.6.525
      PHB0.1.984−0.9.67−0.3.797
      PHB2−0.1.982−0.3.847−0.3.707
      PHGDH−0.7.862−0.4.7920.4.463
      PHPT1−0.3.947−0.5.7530.4.462
      PI4KA−0.9.878−0.7.677−0.1.958
      PIK3C3−0.5.941−0.3.8260.1.966
      PIMREG−0.7.9−1.5830.2.887
      PITHD1−0.1.982−0.5.8260.1.983
      PITPNB−0.5.927−1.3.4210.6.505
      PITRM1−0.8.9−0.5.7650.4.515
      PKD2−0.8.862−0.4.832−0.1.957
      PKM−0.3.957−0.4.866−0.4.729
      PKP4−0.9.966−0.1.973−0.8.346
      PLA2G2A−0.9.862−0.3.8210.1.916
      PLAUR0.5.9720.9.891−1.7.447
      PLCD1−0.7.9−0.3.895−0.6.518
      PLCH1−0.2.9820.2.9620.3.902
      PLD30.1.984−0.3.906−0.4.674
      PLEC0.3.957−0.2.9170.1.945
      PLG0.2.982−0.6.7920.7.44
      PLIN1−0.5.912−0.2.9390.4.571
      PLIN3−0.1.982−0.1.9920.2.818
      PLOD10.2.982−0.6.7590.2.863
      PLP2−0.8.9−0.7.6570.6.368
      PLS3−0.5.90.3.917−0.1.945
      PLTP0.5.927−0.5.895−0.4.812
      PLXDC2−0.3.969−0.5.792−0.1.998
      PLXNB2−0.1.982−0.5.8260.9.234
      PNP0.4.929−0.9.4520.7.28
      PODN0.4.927−0.1.993−0.1.974
      POLD10.5.974−0.2.9330.5.441
      PON10.3.967−0.6.7030.9.08
      POSTN0.5.9271.4.761−0.9.657
      POTEF−0.4.966−0.9.6141.2.093
      POTEI−0.7.9−0.2.9520.7.493
      POTEJ−0.4.941−1.2.4210.9.258
      PPA1−0.2.972−1.5830.4.774
      PPA20.3.941−1.5520.6.484
      PPBP0.3.969−0.7.640.5.483
      PPCS0.1.982−0.1.9730.4.588
      PPFIBP10.4.9270.2.9530.2.899
      PPIA−0.3.947−0.4.8260.4.587
      PPIB0.1.984−0.2.9370.5.451
      PPIC0.3.959−0.4.7920.2.862
      PPM1F0.2.982−0.2.9330.2.824
      PPME10.4.9720.2.9170.1.945
      PPP1CB−0.7.90.5.824−0.4.728
      PPP1CC−0.1.982−0.2.9530.5.688
      PPP1R12A−0.1.982−0.2.932−0.5.526
      PPP1R12B−1.8570.3.951−0.4.862
      PPP1R14A−1.1.857−0.1.942−0.11.00
      PPP1R70.3.969−0.7.759−0.4.688
      PPP2R1A−0.3.941−0.7.762−0.4.681
      PPP6R3−0.6.9690.3.9170.1.963
      PPT10.3.969−0.1.934−0.2.825
      PRAF2−0.1.982−1.8210.4.863
      PRDBP−1.862−0.4.8210.6.343
      PRDX1−0.2.974−0.3.8910.2.855
      PRDX20.3.903−0.4.911−0.7.506
      PRDX30.3.93−0.4.7460.3.602
      PRDX40.4.957−0.4.7590.7.083
      PRDX50.1.982−0.2.8260.4.262
      PRDX6−0.2.9410.4.862−0.1.988
      PRELP−0.1.982−0.3.8080.3.402
      PRKACA−0.4.903−0.4.7030.2.697
      PRKACB−1.1.862−0.9.4970.8.198
      PRKAR1A−0.1.982−0.4.8020.11.00
      PRKAR2A−0.6.9−0.6.821−0.6.591
      PRKCB−1.6.9−0.4.7620.3.585
      PRKCSH0.1.982−0.4.826−0.2.863
      PRKG1−0.9.857−1.5.769−0.1.998
      PROC0.3.954−0.4.7920.5.441
      PROS1−0.2.974−0.3.911−0.7.344
      PROSC0.1.982−0.7.5260.9.057
      PROX2−0.6.9−1.2880.9.105
      PRPF4B0.3.981−0.3.9370.3.834
      PRPS10.2.972−0.3.917−0.4.704
      PRR36−0.3.9810.2.9330.1.979
      PRSS230.2.9820.1.9650.2.894
      PRTG0.7.9−0.3.93−0.1.998
      PRTN3−0.3.9820.2.9420.1.991
      PRXL2A−0.7.878−0.9.6381.6.037
      PSAP−0.4.9030.5.826−0.7.452
      PSIP10.1.982−1.2.2860.6.416
      PSMA1−0.1.984−0.4.7920.1.979
      PSMA20.1.982−0.3.8260.4.544
      PSMA30.2.969−0.7.5830.7.234
      PSMA40.1.982−0.4.7920.5.366
      PSMA50.1.982−0.2.8990.4.497
      PSMA6−0.1.982−0.6.5870.6.153
      PSMA7−0.4.903−0.6.5260.7.123
      PSMB1−0.2.976−0.7.3270.7.083
      PSMB2−0.1.982−0.6.7690.2.912
      PSMB30.1.982−0.5.7920.3.728
      PSMB4−0.2.974−0.6.7760.5.499
      PSMB5−0.1.984−0.8.4740.9.107
      PSMB6−0.1.997−0.7.5920.5.409
      PSMB7−0.1.982−0.7.6770.6.342
      PSMB8−0.8.878−0.5.7180.5.35
      PSMB90.1.982−0.4.9170.3.878
      PSMC10.2.982−1.5830.2.898
      PSMC2−0.1.982−0.6.6740.7.21
      PSMC30.2.982−0.2.9170.4.657
      PSMC4−0.1.982−0.1.988−0.1.974
      PSMC5−0.2.969−0.6.7760.7.286
      PSMC60.4.927−0.3.8260.3.763
      PSMD1−0.1.982−0.3.8480.1.945
      PSMD11−0.1.9820.3.8950.2.888
      PSMD12−0.2.982−0.3.8620.3.811
      PSMD13−0.1.992−0.4.7920.4.537
      PSMD140.2.982−0.4.8950.2.906
      PSMD20.2.982−0.5.7920.5.526
      PSMD3−0.1.982−0.6.6320.7.133
      PSMD5−0.5.9−0.1.9930.2.863
      PSMD60.1.982−0.2.9330.1.945
      PSMD7−0.2.982−0.4.847−0.2.836
      PSMD9−0.5.9−0.3.8480.3.631
      PSME10.1.982−0.5.8080.4.707
      PSME20.3.927−0.9.3230.5.376
      PSMF1−0.4.927−0.4.750.5.286
      PTBP10.2.982−0.4.8150.7.185
      PTGES3−0.4.941−0.4.8160.1.994
      PTGIS−0.9.857−0.5.7820.6.328
      PTGR1−0.1.982−0.6.7590.2.818
      PTK2−0.5.9−0.1.978−0.8.185
      PTMA−0.2.9740.4.866−0.5.675
      PTMS−0.4.903−0.7.6740.2.835
      PTPA−0.1.984−0.3.8620.1.925
      PTPN11−0.2.972−0.7.6740.3.784
      PTPN13−0.3.982−0.6.6470.5.301
      PTPN4−1.862−0.1.996−0.2.814
      PTRF−0.4.9410.6.792−0.9.307
      PURA−0.5.90.2.942−1.2.137
      PUS10−0.7.944−0.1.989−0.4.707
      PXDN−0.4.942−0.3.865−0.2.835
      PYGB−0.5.903−1.1.7890.5.825
      PYGL−0.3.969−0.5.8150.2.916
      PZP−0.3.974−0.5.7920.1.979
      QARS10.6.90.3.861−0.5.441
      QDPR−0.3.9570.4.869−0.7.497
      QSOX1−0.3.9410.1.9610.5.532
      QTRT1−0.4.966−0.7.5960.4.497
      RAB10−0.2.982−0.3.877−0.1.97
      RAB11B−0.8.903−1.6040.6.483
      RAB140.2.982−0.1.985−0.1.915
      RAB180.4.9740.3.948−1.1.421
      RAB21−0.1.992−0.2.9510.3.743
      RAB23−0.9.8570.1.9890.3.848
      RAB2A−0.3.957−0.4.8180.4.618
      RAB35−0.1.982−0.5.792−0.5.578
      RAB41−0.5.903−0.6.7060.4.646
      RAB5B−0.7.878−0.1.951−0.11.00
      RAB5C−0.5.969−1.4.2250.9.17
      RAB7A0.1.982−1.4520.3.714
      RAC1−0.4.941−1.7.4591.3.287
      RAC3−0.2.982−0.4.7620.5.308
      RACK10.1.982−0.8.7180.4.733
      RAD18−0.3.982−0.1.993−0.2.961
      RAD23A−0.5.927−0.2.9130.2.739
      RAD23B0.2.9690.6.826−0.9.452
      RALY−0.5.903−0.7.7690.3.863
      RAN0.1.982−0.4.8020.5.287
      RANBP1−0.2.966−0.5.7920.1.974
      RAP1A−0.2.982−0.1.9980.1.961
      RAP1GDS1−0.2.982−0.7.5830.5.441
      RARRES2−0.4.9410.3.934−0.4.726
      RBBP8NL−0.9.9−0.1.985−0.2.913
      RBCK1−0.3.957−0.2.951−0.3.811
      RBMX−0.1.982−0.5.899−0.5.757
      RBP1−0.8.862−1.1.3910.8.234
      RBP40.3.946−0.3.8260.3.726
      RBPMS−0.6.9−0.5.808−0.4.65
      RBX10.9.9−0.9.5241.1.05
      RCN1−0.3.969−0.6.7590.11.00
      RCN30.2.982−0.8.7921.6.068
      RDX0.1.982−0.6.7180.4.633
      RECQL−0.1.9920.1.9930.1.913
      REEP50.2.9820.6.815−0.6.658
      REEP6−0.4.957−0.2.9420.2.906
      RFTN1−0.2.979−0.6.8080.8.391
      RGS22−0.5.941−0.6.8080.2.863
      RHBDF1−0.8.9−0.5.7920.3.726
      RHOA−0.1.984−1.4.3240.9.229
      RHOB−0.4.93−0.6.822−0.3.855
      RHOC−0.5.9410.2.953−0.2.883
      RHOC−0.5.9410.1.998−0.4.638
      RHOG−0.2.982−0.5.8330.1.995
      RIC8A−0.1.9820.2.923−0.4.657
      RIF1−0.3.9570.4.818−0.4.525
      RILPL1−0.3.963−0.4.8260.1.945
      RINT1−0.7.941−0.4.7920.2.811
      RNASE10.6.912−1.2.7620.5.797
      RNASE4−0.4.957−0.2.9720.7.487
      RNF31−0.2.9820.1.986−0.4.684
      RNH1−0.3.903−0.7.8190.6.688
      RNPEP0.2.982−0.2.899−0.2.825
      RPL10−0.1.9970.1.9930.2.871
      RPL10A−0.2.9820.1.985−0.1.962
      RPL11−0.2.982−0.2.942−0.1.99
      RPL12−0.1.982−0.5.8260.4.739
      RPL13−0.2.9820.1.993−0.2.897
      RPL140.1.982−0.4.8260.3.818
      RPL15−0.1.982−0.4.8480.4.593
      RPL170.2.9820.1.973−0.2.893
      RPL18−0.2.982−0.4.8360.6.487
      RPL18A−0.1.982−0.5.8180.3.77
      RPL22−0.4.9410.3.899−0.4.72
      RPL230.2.982−0.5.8180.1.952
      RPL23A0.1.982−0.2.9170.3.688
      RPL240.5.927−0.4.8080.5.447
      RPL27−0.3.9720.3.9330.3.82
      RPL27A−0.1.992−0.7.7920.4.74
      RPL28−0.1.982−0.3.8990.3.8
      RPL290.2.974−0.3.8910.2.827
      RPL3−0.1.982−0.3.8910.5.523
      RPL30−0.6.903−0.2.9170.2.913
      RPL31−0.1.982−0.9.6530.4.744
      RPL340.4.957−0.7.7920.6.543
      RPL35−0.7.9270.4.8990.1.968
      RPL380.7.927−1.2.6740.5.719
      RPL40.1.9970.3.9440.5.753
      RPL5−0.2.981−0.3.9170.3.825
      RPL6−0.2.982−0.5.8180.3.811
      RPL7−0.2.974−0.4.8180.3.757
      RPL7A−0.1.997−0.1.988−0.2.863
      RPL80.3.978−0.2.9420.2.888
      RPL9−0.1.992−0.5.8590.7.487
      RPLP0−0.3.974−0.4.8720.4.757
      RPLP1−0.2.982−0.5.8260.3.881
      RPLP2−0.3.966−0.5.8190.3.742
      RPN10.2.972−0.5.7920.2.811
      RPN20.1.982−0.1.9720.3.726
      RPS10−0.2.9820.1.9740.1.974
      RPS11−0.1.982−0.6.780.4.655
      RPS120.2.957−0.3.8590.2.824
      RPS130.1.993−0.1.9890.2.703
      RPS14−0.5.903−0.6.7920.6.483
      RPS15A−0.2.982−0.6.7920.1.962
      RPS16−0.4.957−0.1.973−0.1.961
      RPS18−0.1.982−0.5.8150.2.887
      RPS19−0.2.974−0.2.9350.1.962
      RPS2−0.1.982−0.5.7420.4.595
      RPS20−0.1.982−0.2.9530.1.962
      RPS21−0.2.982−0.4.8530.3.801
      RPS23−0.2.982−0.8.6150.7.342
      RPS24−0.6.9030.3.917−0.4.697
      RPS25−0.1.997−0.4.899−0.3.815
      RPS27L−1.9.857−0.4.8480.4.705
      RPS28−0.3.982−1.2.674−0.8.532
      RPS30.1.9821.1.792−1.4.363
      RPS3A−0.1.982−0.4.8210.4.506
      RPS4X0.1.982−0.2.9170.2.894
      RPS50.1.9840.1.9850.1.989
      RPS60.2.982−0.2.9330.2.824
      RPS6KA2−0.3.9820.4.792−0.3.704
      RPS6KA3−1.7.857−1.1.7180.8.506
      RPS7−0.3.969−1.9.4420.3.909
      RPS8−0.1.982−0.5.8210.2.889
      RPS9−0.3.9460.1.974−0.1.901
      RPSA0.3.969−0.1.966−0.3.8
      RRAD−0.8.9−0.6.7450.8.173
      RRAS−0.7.878−0.7.821−0.2.916
      RRBP10.8.862−0.3.888−0.5.609
      RSAD2−0.9.90.3.8910.6.483
      RSU1−0.4.9270.3.942−1.2.347
      RTCB−0.4.927−0.4.8120.1.97
      RTN40.1.982−0.2.899−0.2.863
      RTRAF−0.2.9820.2.934−0.1.939
      RUNDC3A0.2.982−0.5.6790.4.471
      RUVBL1−0.1.982−0.9.751.306
      RUVBL20.1.984−0.1.9510.1.965
      S100A110.1.982−0.3.8260.4.592
      S100A130.2.982−0.2.9220.2.753
      S100A16−0.1.982−0.3.8770.4.59
      S100A4−0.4.903−0.4.8210.3.719
      S100A6−0.2.969−0.2.917−0.3.763
      S100A8−0.4.963−0.5.6990.3.578
      SAA1−1.9.8570.1.993−0.5.726
      SAMHD1−0.1.982−1.7.474−0.2.931
      SAMM50−1.2.862−0.7.7180.6.437
      SARS1−0.3.941−0.9.762−0.3.883
      SBDS−0.6.9−0.5.7850.2.825
      SBSPON−0.5.903−0.8.5830.3.811
      SCARB2−0.5.946−0.2.939−0.4.699
      SCN8A−0.6.941−0.3.934−0.3.865
      SCRN1−0.6.862−0.5.853−0.1.979
      SCUBE3−0.7.9−0.7.5860.1.921
      SCYL2−0.8.9410.3.916−0.9.187
      SDHA−0.2.982−2.5371.2.474
      SDHB−0.3.972−0.5.8180.3.729
      SEC11B−0.1.99−0.1.983−0.2.868
      SEC130.2.982−0.6.7620.6.441
      SEC14L5−0.7.9−0.3.9040.4.674
      SEC22B0.3.974−0.9.7450.2.898
      SEC23A0.3.9720.3.872−0.1.941
      SEC31A0.4.927−0.1.9890.3.765
      SELENBP1−0.2.9270.3.8620.1.932
      SELENOM−0.2.982−0.6.3910.4.335
      SELENOP−0.2.9820.2.951−0.3.757
      SEMA3B−0.8.862−0.5.8080.3.734
      SEMA5B−0.9.9−0.2.961−0.7.399
      SERBP10.1.982−2.3231.1.36
      SERPINA1−0.1.9880.2.951−0.1.974
      SERPINA100.2.982−1.2.2251.1.025
      SERPINA3−0.5.903−0.8.7620.9.337
      SERPINA4−0.1.982−1.1.4010.6.389
      SERPINA5−0.5.9−0.4.8150.3.702
      SERPINA60.1.984−0.4.826−0.2.862
      SERPINA70.3.966−0.8.5190.9.135
      SERPINB1−0.2.982−1.3631.2.03
      SERPINB6−0.5.941−0.1.998−0.1.894
      SERPINC1−0.2.969−0.5.8260.1.991
      SERPIND1−0.2.972−0.5.7170.3.613
      SERPINE20.2.982−0.9.3460.7.161
      SERPINF10.3.957−0.5.8480.7.572
      SERPINF2−0.2.982−0.5.7060.7.128
      SERPING1−0.3.9570.2.944−0.3.705
      SERPINH1−0.1.982−1.3460.8.198
      SETD1B−0.5.927−0.2.9330.2.911
      SF3B60.2.982−1.1.4210.7.366
      SFPQ0.6.9−1.5.4971.6.094
      SFRP1−0.4.9410.3.9070.4.681
      SFXN3−0.3.941−0.2.933−0.2.863
      SGCD−0.9.857−0.5.7910.2.863
      SH3BGRL−0.3.947−0.1.985−0.9.123
      SH3BGRL30.1.982−0.8.4520.6.329
      SH3BP5−0.4.927−0.5.7590.6.305
      SH3GLB1−0.2.982−0.2.917−0.2.825
      SH3GLB2−0.1.982−0.4.8210.2.791
      SH3RF2−0.4.947−0.7.7220.6.441
      SHMT1−0.2.9820.5.815−0.8.276
      SIN3B−0.2.982−0.3.8990.1.93
      SKP1−0.2.982−1.6670.8.394
      SLC22A17−0.5.959−0.4.8160.3.739
      SLC25A1−0.3.957−1.9.3911.4.226
      SLC25A110.1.982−0.3.899−0.1.97
      SLC25A120.2.974−0.2.9370.3.768
      SLC25A24−0.1.9820.5.808−0.3.787
      SLC25A30.1.9840.1.988−0.2.916
      SLC25A4−1.857−0.1.9930.1.961
      SLC25A50.1.997−0.3.928−0.8.313
      SLC27A20.1.982−0.5.8910.5.753
      SLC27A3−0.1.983−0.6.7130.6.286
      SLC2A10.2.982−0.2.9560.1.961
      SLC2A12−1.8570.1.9880.2.916
      SLC30A10−0.4.982−1.2.3240.3.825
      SLC3A20.6.9−1.4.7181.514
      SLC4A10.9.8620.1.9720.5.447
      SLC7A6−0.5.941−0.2.9331.1.164
      SLC9A3R1−0.3.9820.2.973−0.6.567
      SLC9A5−0.7.903−1.1.5830.9.339
      SLC9A8−1.4.857−1.5.4970.8.526
      SLMAP−0.8.8620.1.98−1.5.084
      SLPI−1.862−0.2.951−0.6.328
      SLX4−1.90.5.826−1.5.08
      SMARCA5−0.5.9−0.9.792−0.1.971
      SMOC2−0.2.982−0.6.6990.2.894
      SMTN−0.9.8570.1.988−0.2.84
      SNCA0.4.927−0.4.826−0.5.467
      SNCG−1.862−0.8.6041.2.058
      SND10.3.941−0.6.812−0.5.688
      SNRNP200−0.7.940.4.815−0.1.928
      SNRPD1−0.3.974−1.1.7420.5.787
      SNRPD20.3.957−0.6.780.4.691
      SNRPD30.1.982−0.1.9880.4.688
      SNTB2−0.5.9−0.6.7590.7.324
      SNX10.4.941−0.4.821−0.1.911
      SNX12−0.6.90.1.9940.3.674
      SNX18−0.4.927−0.3.917−0.4.664
      SNX20.3.9650.1.989−0.5.584
      SNX29−0.5.927−0.3.8990.5.478
      SNX3−0.1.972−0.7.770.3.863
      SNX6−0.3.957−0.11.00−0.1.815
      SNX9−0.8.9−0.6.5740.4.444
      SOD1−0.2.941−0.8.713−0.11.00
      SOD2−0.1.993−0.3.7850.1.863
      SOD3−1.862−0.6.5370.6.179
      SOGA1−0.1.984−0.3.899−0.7.394
      SON−0.2.982−0.6.8330.5.719
      SORBS1−0.8.862−0.2.953−0.1.958
      SORBS2−1.857−0.3.919−0.6.452
      SORBS3−0.6.9−0.6.792−0.5.635
      SORD−0.8.9−0.3.912−0.4.624
      SOST−0.8.9−0.6.814−0.3.863
      SOX6−0.2.9820.4.911−1.1.285
      SPARC0.4.93−0.9.3270.7.128
      SPARCL1−0.6.862−0.2.9510.5.495
      SPCS22.857−1.2860.5.451
      SPCS30.3.9721.7211.334
      SPON10.3.9470.1.9980.3.808
      SPR−0.7.90.2.9440.2.862
      SPTA10.6.9−0.7.750.1.985
      SPTAN1−0.2.9820.1.9880.6.523
      SPTB0.7.9−0.6.7250.5.529
      SPTBN1−0.2.9820.1.9930.7.377
      SQOR0.2.982−0.4.8150.3.757
      SQRD0.2.982−0.6.7760.7.301
      SREBF2−0.4.9820.2.942−0.1.988
      SRFBP1−0.7.9−0.1.993−0.4.862
      SRGAP30.3.982−1.2.4970.5.652
      SRI−0.1.9740.2.9660.2.953
      SRM0.2.972−0.2.8440.1.898
      SRP9−0.3.963−0.4.8080.6.326
      SRPX−0.7.916−0.5.7920.3.784
      SRRT−0.4.9460.5.861−1.1.28
      SRSF1−0.4.9440.6.792−0.9.209
      SRSF3−0.3.957−0.5.8120.2.911
      SRSF7−0.6.9−0.1.997−0.3.752
      SSB−0.4.9−0.1.989−0.5.552
      SSBP10.4.972−0.8.4590.4.564
      SSR10.6.91.632−0.7.467
      SSR40.1.9820.1.9890.5.452
      SSTR2−1.2.9−0.3.9420.3.84
      ST3GAL6−1.4.857−1.6.7010.4.863
      STAB1−0.4.941−0.3.933−1.2.203
      STAMBP0.7.972−0.6.8080.2.913
      STAT1−0.1.9820.5.9420.3.945
      STAT6−0.3.957−0.6.8260.5.707
      STIP1−0.2.960.1.986−0.3.688
      STK25−0.7.947−0.6.5830.4.453
      STK310.7.9−0.6.897−0.1.966
      STN1−0.5.922−0.3.9361.35
      STOM0.2.982−1.9.2251.4.064
      STT3A−0.1.9820.3.93−0.1.968
      STX7−0.2.972−0.1.997−0.1.962
      STXBP3−0.1.982−0.3.8220.2.862
      SUCLA20.1.982−0.3.8090.3.647
      SUCLG1−0.2.982−0.5.6790.6.28
      SUCLG2−0.1.982−0.6.8530.4.811
      SULF10.1.988−0.4.8150.4.654
      SUMF2−0.6.90.3.861−0.3.753
      SUN2−0.7.864−0.5.836−0.2.878
      SUSD2−0.5.927−0.1.985−0.7.354
      SUSD5−0.7.9−0.2.965−0.4.707
      SVIL0.1.9880.1.989−0.8.346
      SYG0.3.9660.2.917−0.2.862
      SYHC−0.1.9820.1.9880.3.812
      SYNCRIP0.2.979−0.3.880.3.799
      SYNE1−0.6.9−0.1.9660.3.743
      SYNM−0.2.974−0.4.831−0.2.865
      SYNPO−0.2.982−0.1.961−0.1.912
      SYNPO2−0.5.90.2.941−0.3.719
      SYPL1−0.6.927−0.1.972−0.4.59
      TAGLN−1.2.857−0.5.839−0.1.963
      TAGLN2−0.4.927−0.8.769−0.5.668
      TALDO10.2.957−0.5.7920.1.945
      TARDBP−0.1.982−0.2.8970.3.447
      TARS10.4.941−0.6.7040.5.416
      TARS2−0.7.9290.1.9730.3.757
      TASOR2−0.5.927−0.9.8080.2.945
      TAX1BP3−0.7.9030.2.957−0.6.492
      TBC1D5−1.1.862−0.8.7920.1.962
      TBCA−0.5.9−0.2.961−1.278
      TBCB−0.5.9−0.7.6240.2.82
      TCP1−0.2.982−0.7.5190.3.769
      TENT20.1.982−0.4.7920.3.691
      TES−0.6.9−0.3.9340.4.811
      TF−0.2.974−0.1.989−0.5.363
      TFEB−0.9.941−1.3460.8.157
      TFG0.1.992−1.1.8210.2.956
      TGFB10.2.982−0.3.8990.3.762
      TGFB1I1−0.9.8570.8.708−0.7.438
      TGFBI−0.3.969−0.3.891−0.7.368
      TGM2−0.8.862−0.3.8470.1.945
      TH−1.2.862−0.5.792−0.3.72
      THBS11.3.857−0.3.933−1.343
      THBS20.4.970.2.9531.1.16
      THOP1−0.5.9270.1.9850.3.84
      THSD1−0.6.862−1.1.5080.6.497
      THSD4−0.3.9410.2.904−0.8.135
      THTPA1.6.8620.5.691−0.7.094
      THY10.6.91.1.7920.6.761
      TIMP10.8.9−0.4.8261.179
      TIMP2−0.4.957−0.1.9940.8.409
      TIMP31.878−0.6.8080.2.863
      TINAGL1−1.1.8570.2.950.8.447
      TJP20.3.981−0.2.942−1.182
      TKT−0.3.90.3.895−0.1.957
      TLE7−0.3.927−0.5.4010.3.447
      TLN1−0.2.974−0.5.6320.3.671
      TLN2−0.4.9410.2.904−0.4.557
      TMC30.2.9820.2.933−0.5.489
      TMCC20.7.903−0.4.9320.6.791
      TMED7−0.4.941−0.7.7921.3.135
      TMEM109−0.5.9−0.4.8260.1.979
      TMEM198−0.3.972−0.6.6740.2.84
      TMEM214−0.7.9−1.1.5860.8.406
      TMEM33−0.6.969−0.2.933−0.5.623
      TMEM43−0.2.9740.5.917−1.526
      TMEM67−1.2.862−0.3.9040.1.978
      TMOD1−0.7.862−0.9.762−0.3.84
      TMSB4X0.1.988−0.7.656−0.1.97
      TNC−0.2.982−0.3.8960.4.74
      TNFRSF11B0.1.984−0.7.8080.5.676
      TNFSF13−0.4.941−0.4.830.4.623
      TNN−0.2.982−0.1.986−0.4.72
      TNPO1−0.2.982−1.2.3911.1.128
      TNPO20.4.972−0.2.8990.1.913
      TNRC6C−0.4.969−0.7.8261.1.397
      TNS1−0.8.862−1.9.2251.6.044
      TNS2−0.1.9820.1.988−0.8.273
      TNXB−0.8.8570.2.916−0.3.743
      TOLLIP−0.1.982−0.9.3920.1.933
      TOM1−0.3.9670.4.847−0.5.616
      TOM1L20.5.9−0.5.8020.2.825
      TOR1AIP1−0.3.9470.5.792−0.11.00
      TPD52L20.1.9920.3.826−0.6.334
      TPI1−0.4.9−0.5.7920.5.489
      TPM1−0.9.862−0.5.670.2.878
      TPM2−1.3.862−0.7.78−0.3.811
      TPM30.4.9−0.7.815−0.6.626
      TPM4−0.1.982−0.3.8480.6.198
      TPP10.6.9−0.3.8260.2.77
      TPP2−0.7.9−0.1.9660.7.286
      TPT1−0.3.974−0.8.7210.2.911
      TRIM38−1.6.857−0.5.8530.2.916
      TRIOBP−0.1.982−0.8.808−0.8.561
      TRIP60.1.9820.5.792−0.6.42
      TSG101−0.1.990.4.853−0.3.811
      TSN0.1.993−0.5.8210.4.641
      TTN−0.1.988−0.2.9140.3.8
      TTR0.1.984−0.6.7180.5.378
      TTYH2−0.6.862−0.7.5830.7.179
      TUBA4A0.1.982−0.1.951−0.5.363
      TUBB0.1.9870.1.9880.1.893
      TUBB1−0.1.99−0.5.7920.6.441
      TUBB2A0.1.9820.6.899−0.6.753
      TUBB4A0.5.969−0.4.8150.5.521
      TUBB4B−0.3.9740.4.930.2.962
      TUBB6−0.1.982−0.9.5520.7.352
      TUFM0.1.982−0.4.8180.4.697
      TUT7−0.6.903−0.2.9170.2.769
      TVC2−1.862−0.4.895−0.3.84
      TWF1−0.4.93−0.6.6740.3.705
      TWF20.3.9820.3.9330.11.00
      TXN−0.3.957−0.4.7920.2.849
      TXNDC121.1.8620.9.7550.2.916
      TXNDC17−0.4.9−0.7.4010.4.441
      TXNDC50.3.957−0.5.7920.7.21
      TXNL1−0.2.957−0.6.4770.4.344
      TXNRD1−0.4.912−0.6.6680.3.734
      TYMP0.5.9−0.2.9320.7.328
      TYRP1−0.5.941−0.7.7920.2.878
      U2AF20.5.9120.2.9440.3.737
      UAP1−0.6.9−0.1.973−0.5.59
      UBA1−0.2.941−0.3.8080.1.902
      UBAP2L0.2.9690.1.9930.2.8
      UBE2I−0.5.903−0.1.978−0.4.654
      UBE2K0.4.941−0.4.8080.7.199
      UBE2L30.1.992−0.1.9890.1.968
      UBE2M−0.2.982−0.3.9170.2.913
      UBE2N−0.4.941−0.3.933−0.2.863
      UBE2O−1.4.857−0.6.818−0.9.306
      UBE2V10.1.982−0.2.9510.2.841
      UBL5−0.7.862−0.8.5830.2.911
      UBR4−0.9.9030.4.934−1.2.399
      UCHL1−0.4.927−0.7.7030.3.76
      UFC1−0.3.903−0.5.6140.3.693
      UFL1−0.1.993−0.4.8440.4.701
      UFM1−0.1.982−0.9.4570.8.145
      UGDH−0.3.974−0.2.933−0.1.968
      UGGT10.4.9410.4.822−0.1.974
      UGP2−0.3.9−0.2.822−0.1.913
      UNC45A−0.2.982−0.5.8210.3.761
      UQCR100.5.9030.2.9220.3.779
      UQCRC10.3.9660.1.9820.3.825
      UQCRC20.3.9720.3.895−0.1.977
      UQCRH−0.1.982−0.3.8920.3.843
      USO1−0.6.9−1.1.4310.6.463
      USP14−0.1.982−0.5.7920.4.561
      USP15−1.862−0.5.855−0.6.581
      USP17L130.1.99−0.4.7620.5.391
      USP17L18−0.2.974−0.3.8910.1.961
      USP17L19−0.9.862−0.8.721−0.1.958
      USP17L200.3.967−0.3.8530.5.409
      USP17L220.1.982−0.2.9110.3.744
      USP5−0.1.997−0.1.9510.1.911
      UTP14A−0.7.903−0.9.7590.2.902
      UTRO−0.3.941−0.3.853−0.1.989
      VAPA0.1.982−0.1.9890.2.943
      VASP0.1.9920.3.797−0.3.543
      VAT1−0.1.988−0.4.8080.3.572
      VCAN−0.7.90.3.922−0.9.286
      VCL−0.6.862−0.2.933−0.4.457
      VCP0.2.972−0.1.9440.3.652
      VDAC10.3.9−0.1.9880.4.402
      VDAC20.3.966−0.4.8260.6.342
      VDAC30.2.9820.3.917−0.2.922
      VILL−0.3.969−1.5.2251.2.071
      VIM−0.4.9−0.4.816−0.1.962
      VIRMA−0.9.857−0.3.861−0.6.409
      VPS11−0.2.982−0.1.988−0.1.931
      VPS29−0.1.982−0.1.9720.1.974
      VPS35−0.4.941−0.5.7590.2.8
      VPS4B0.1.9820.11.000.1.968
      VTN0.1.982−0.3.8990.3.715
      VWA1−0.3.976−0.4.8260.2.873
      VWA3A−0.1.9840.3.858−0.4.674
      VWA3B−0.2.982−1.6740.8.408
      WASHC10.2.9820.4.946−0.3.944
      WASHC4−2.2.857−0.3.944−1.9.108
      WBP11−1.1.8620.2.946−1.3.188
      WDR1−0.4.862−0.3.819−0.2.71
      WDR76−0.2.974−0.8.4740.7.262
      WDR82−0.5.966−0.2.973−0.4.84
      WDR83OS−1.8720.1.974−1.1.26
      WISP2−1.2.857−0.7.759−0.5.526
      WRAP73−1.2.862−1.3.5830.1.968
      WTIP−0.7.927−0.6.826−0.1.971
      XDH−0.5.9340.2.962−0.6.526
      XPO1−0.2.982−0.1.993−0.2.894
      XRCC5−0.2.982−0.3.8910.2.9
      XRCC6−0.4.903−0.4.802−0.11.00
      XRN1−1.1.9−0.9.762−0.2.945
      YAP1−0.3.969−0.4.8080.2.84
      YKT6−0.5.903−0.5.80.1.993
      YPEL1−1.1.9−1.1.742−0.11.00
      YWHAB−0.2.941−0.3.8080.1.916
      YWHAE−0.1.982−0.4.7920.4.526
      YWHAG−0.4.9−0.5.5830.2.795
      YWHAH−0.1.982−0.4.7920.3.613
      YWHAQ−0.4.903−0.4.815−0.1.998
      YWHAZ−0.1.982−0.2.8910.2.825
      ZBTB21−0.8.8620.1.993−0.8.287
      ZC2HC1C−0.8.90.4.891−1.1.187
      ZMYND8−0.5.9270.2.934−0.7.431
      ZNF3501.5.862−0.1.9851.6.157
      ZNF385A−1.3.8620.1.998−1.3.287
      ZNF479−0.4.903−0.3.853−0.2.886
      ZNF507−0.4.947−0.9.6340.5.563
      ZNF597−0.8.9−0.8.762−0.1.974
      ZSCAN9−0.6.974−0.3.973−0.4.902
      ZSWIM9−0.3.957−1.1.3270.8.179
      ZYX−0.2.969−0.1.983−0.2.84
      Log2FC, Log2 fold change; TAA, thoracic aorta aneurysm; TADA, thoracic aorta dissection and aneurysm; TBAD, type B aortic dissection.
      aFalse discovery rate.

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